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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleAdult Brain
Open Access

Machine Learning in Differentiating Gliomas from Primary CNS Lymphomas: A Systematic Review, Reporting Quality, and Risk of Bias Assessment

G.I. Cassinelli Petersen, J. Shatalov, T. Verma, W.R. Brim, H. Subramanian, A. Brackett, R.C. Bahar, S. Merkaj, T. Zeevi, L.H. Staib, J. Cui, A. Omuro, R.A. Bronen, A. Malhotra and M.S. Aboian
American Journal of Neuroradiology April 2022, 43 (4) 526-533; DOI: https://doi.org/10.3174/ajnr.A7473
G.I. Cassinelli Petersen
aFrom the Department of Radiology and Biomedical Imaging (G.I.C.P., T.V., H.S., R.C.B., S.M., T.Z., L.H.S., J.C., R.A.B., A.M., M.S.A.)
dUniversitätsmedizin Göttingen (G.I.C.P.), Göttingen, Germany
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  • ORCID record for G.I. Cassinelli Petersen
J. Shatalov
eUniversity of Richmond (J.S.), Richmond, Virginia
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T. Verma
aFrom the Department of Radiology and Biomedical Imaging (G.I.C.P., T.V., H.S., R.C.B., S.M., T.Z., L.H.S., J.C., R.A.B., A.M., M.S.A.)
fNew York University (T.V.), New York, New York
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W.R. Brim
gWhiting School of Engineering (W.R.B.), Johns Hopkins University, Baltimore, Maryland
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H. Subramanian
aFrom the Department of Radiology and Biomedical Imaging (G.I.C.P., T.V., H.S., R.C.B., S.M., T.Z., L.H.S., J.C., R.A.B., A.M., M.S.A.)
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A. Brackett
bCushing/Whitney Medical Library (A.B.)
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R.C. Bahar
aFrom the Department of Radiology and Biomedical Imaging (G.I.C.P., T.V., H.S., R.C.B., S.M., T.Z., L.H.S., J.C., R.A.B., A.M., M.S.A.)
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S. Merkaj
aFrom the Department of Radiology and Biomedical Imaging (G.I.C.P., T.V., H.S., R.C.B., S.M., T.Z., L.H.S., J.C., R.A.B., A.M., M.S.A.)
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T. Zeevi
aFrom the Department of Radiology and Biomedical Imaging (G.I.C.P., T.V., H.S., R.C.B., S.M., T.Z., L.H.S., J.C., R.A.B., A.M., M.S.A.)
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L.H. Staib
aFrom the Department of Radiology and Biomedical Imaging (G.I.C.P., T.V., H.S., R.C.B., S.M., T.Z., L.H.S., J.C., R.A.B., A.M., M.S.A.)
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J. Cui
aFrom the Department of Radiology and Biomedical Imaging (G.I.C.P., T.V., H.S., R.C.B., S.M., T.Z., L.H.S., J.C., R.A.B., A.M., M.S.A.)
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A. Omuro
cDepartment of Neurology (A.O.), Yale School of Medicine, New Haven, Connecticut
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R.A. Bronen
aFrom the Department of Radiology and Biomedical Imaging (G.I.C.P., T.V., H.S., R.C.B., S.M., T.Z., L.H.S., J.C., R.A.B., A.M., M.S.A.)
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A. Malhotra
aFrom the Department of Radiology and Biomedical Imaging (G.I.C.P., T.V., H.S., R.C.B., S.M., T.Z., L.H.S., J.C., R.A.B., A.M., M.S.A.)
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M.S. Aboian
aFrom the Department of Radiology and Biomedical Imaging (G.I.C.P., T.V., H.S., R.C.B., S.M., T.Z., L.H.S., J.C., R.A.B., A.M., M.S.A.)
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Figures

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    FIG 1.

    PRISMA flow diagram. This chart delineates the selection process that yielded the 23 studies included in this systematic review.1 The initial search yielded 1135 studies for full-text review, and 704 were eligible, and 16 were included. A second literature search yielded 6 additional studies.

  • FIG 2.
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    FIG 2.

    A, Scatterplot displaying the number of patients included in the data sets. B, Scatterplot of the glioma/PCNSL case ratio in the data sets. A ratio of >1 means more gliomas, a ratio of <1 means more PCNSL, and a ratio = 1 means equal number. C, Source of patients in the data sets. D, Type of validation performed in the studies.

  • FIG 3.
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    FIG 3.

    TRIPOD adherence index. The adherence index for a particular item was calculated as the average points achieved across all studies.

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American Journal of Neuroradiology: 43 (4)
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Vol. 43, Issue 4
1 Apr 2022
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G.I. Cassinelli Petersen, J. Shatalov, T. Verma, W.R. Brim, H. Subramanian, A. Brackett, R.C. Bahar, S. Merkaj, T. Zeevi, L.H. Staib, J. Cui, A. Omuro, R.A. Bronen, A. Malhotra, M.S. Aboian
Machine Learning in Differentiating Gliomas from Primary CNS Lymphomas: A Systematic Review, Reporting Quality, and Risk of Bias Assessment
American Journal of Neuroradiology Apr 2022, 43 (4) 526-533; DOI: 10.3174/ajnr.A7473

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Machine Learning in Differentiating Gliomas from Primary CNS Lymphomas: A Systematic Review, Reporting Quality, and Risk of Bias Assessment
G.I. Cassinelli Petersen, J. Shatalov, T. Verma, W.R. Brim, H. Subramanian, A. Brackett, R.C. Bahar, S. Merkaj, T. Zeevi, L.H. Staib, J. Cui, A. Omuro, R.A. Bronen, A. Malhotra, M.S. Aboian
American Journal of Neuroradiology Apr 2022, 43 (4) 526-533; DOI: 10.3174/ajnr.A7473
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