Article Figures & Data
Figures
- Fig 1.
MR imaging appearance of PML. T2 (A) and ADC maps with total (B) and central high (>160 × 10−5 mm2/s, indicated by pink and white in C) ADC values with corresponding regions of interest. The lesion demonstrates a typical pattern of high ADC in the center with decreasing values toward the periphery.
- Fig 2.
Changing ADC/DWI measurements in patients with rapid lesion progression and IRIS. A, A small initial lesion has no area of central high ADC (values >160 × 10−5 mm2/s, indicated by pink and white). B, One month after therapy, areas of both the total lesion and central high ADC core have substantially increased.
- Fig 3.
Changing ADC/DWI measurements in patients with slow lesion progression. A, The initial lesion has no area of central high ADC (values >160 × 10−5 mm2/s, indicated by pink and white). B, One month after therapy, ADC values in the lesion center have increased but only slightly and to a lesser magnitude than lesions in patients with rapid progression.
Tables
Patient No. Age Sex Scan Interval (Days) Clinical Progression A 40 F 60 Yes, rapidly progressive dysphagia B 46 M 42 Yes, altered mental status, psychosis C 35 M 34 Yes, worsening altered mental status D 53 M 53 No E 39 M 43 No F 55 M 91 No No. Viral Load CD4 Count JCV Titer (Copies/mL) Max ADC Ratio Size (Pixels) High Central ADC Area (%) Rate of Growth (Pixels/Day) A1 19 800 147 + 2.2 6535 4.5 78 A2 19 800 147 + 1.8 1095 0 98 B 96 444 62 700 2.4 4094 3.2 403 C 101 026 3 10 100 2.7 12 797 1.6 94 D 1068 437 14 800 1.8 480 0 1.9 E 537 000 78 + 1.8 1442 0 7.3 F 713 30 1200 1.6 1341 0 51 -
Note:—+ indicates positive CSF JCV titer with quantitative titers not performed.
-
In this issue
Jump to section
Related Articles
Cited By...
- Progressive multifocal leukoencephalopathy with hypointense halo on MRI
- CNS-Immune Reconstitution Inflammatory Syndrome in the Setting of HIV Infection, Part 1: Overview and Discussion of Progressive Multifocal Leukoencephalopathy-Immune Reconstitution Inflammatory Syndrome and Cryptococcal-Immune Reconstitution Inflammatory Syndrome