Research ArticlePediatric Neuroimaging
Dyslexic Children Have Abnormal Brain Lactate Response to Reading-Related Language Tasks
Todd L. Richards, Stephen R. Dager, David Corina, Sandra Serafini, Aaron C. Heide, Keith Steury, Wayne Strauss, Cecil E. Hayes, Robert D. Abbott, Suzanne Craft, Dennis Shaw, Stefan Posse and Virginia W. Berninger
American Journal of Neuroradiology September 1999, 20 (8) 1393-1398;
Todd L. Richards
Stephen R. Dager
David Corina
Sandra Serafini
Aaron C. Heide
Keith Steury
Wayne Strauss
Cecil E. Hayes
Robert D. Abbott
Suzanne Craft
Dennis Shaw
Stefan Posse

References
- ↵Liberman I, Shankweiler D, Fisher F, Carter B. Explicit syllable and phoneme segmentation in the young child. . J Exp Child Psychol 1974;18:201-212
- Bradley L, Bryant P. Categorizing sounds and learning to read: a causal connection. . Nature 1983;301:419-421
- Wagner R, Toregsen J. The nature of phonological processing and its causal role in the acquisition of reading skills. . Psychol Bull 1987;101:192-212
- ↵Perfetti C. Reading Ability. . New York: Oxford University Press; 1985;
- ↵
- ↵Cardon L, Smith S, Fulker D, Kimberling W, Pennington B, DeFries J. Quantitative trait locus for reading disability on chromosome 6. . Science 1994;266:276-279
- Grigorenko E, Wood F, Meyer M,, et al. Susceptibility loci for distinct components of developmental dyslexia and chromosomes 6 and 15. . Am J Hum Genet 1997;60:27-39
- Berninger V. Reading and Writing Acquisition: A Developmental Neuropsychological Perspective. . Madison, WI: Brown & Benchmark; 1994;
- Olson R, Forsberg H, Wise B. Genes, environment, and the development of orthographic skills. . In: Berninger VW, ed. The Varieties of Orthographic Knowledge, I: Theoretical and Developmental Issues. Dordrcht, the Netherlands: Kluwer; 1994;27-71
- ↵Denckla M, Rudel R. Rapid “automatized” naming (R.A.N.): dyslexia differentiated from other learning disabilities. . Neuropsychologia 1976;14:471-479
- Wolf M, Bally H, Morris R. Automaticity, retrieval processes, and reading: a longitudinal study in average and impaired reading. . Child Dev 1986;57:988-1000
- ↵Hagman JO, Wood F, Buchsbaum MS, Tallal P, Flowers L, Katz W. Cerebral brain metabolism in adult dyslexic subjects assessed with positron emission tomography during performance of an auditory task. . Arch Neurol 1992;49:734-739
- Gross-Glenn K, Duara R, Barker WW,, et al. Positron emission tomographic studies during serial word-reading by normal and dyslexic adults. . J Clin Exp Neuropsychol 1991;13:531-544
- ↵Rumsey JM. Neuroimaging in developmental dyslexia. . In: Lyon GR, Rumsey JM, eds. Neuroimaging: A Window to the Neurological Foundations of Learning and Behavior in Children. Baltimore: Brookes; 1996;57-77
- ↵Shaywitz SE, Shaywitz BA, Pugh KR,, et al. Functional disruption in the organization of the brain for reading in dyslexia. . Proc Natl Acad Sci 1998;95:2636-2641
- Rumsey JM, Nace K, Donohue B, Wise D, Maisog JM, Andreason P. A positron emission tomographic study of impaired word recognition and phonological processing in dyslexic men. . Arch Neurol 1997;54:562-573
- ↵Tsacopoulos M, Magistretti PJ. Metabolic coupling between glia and neurons. . J Neurosci 1996;16:877-885
- ↵Frahm J, Kruger G, Merboldt KD, Kleinschmidt A. Dynamic uncoupling and recoupling of perfusion and oxidative metabolism during focal brain activation in man. . Magn Reson Med 1996;35:143-148
- ↵Prichard J, Rothman D, Novotny E,, et al. Lactate rise detected by H-1 NMR in human visual cortex during physiologic stimulation. . Proc Natl Acad Sci 1992;88:5829-5831
- Sappey-Marinier D, Calabrese G, Fein G, Hugg JW, Biggins C, Weiner MW. Effect of photic stimulation on human visual cortex lactate and phosphates using 1H and 31P MR spectroscopy. . J Cereb Blood Flow Metab 1992;12:584-592
- Richards TL, Gates GA, Gardner JC,, et al. Functional MR spectroscopy of the auditory cortex in healthy subjects and patients with sudden hearing loss. . AJNR Am J Neuroradiol 1997;18:611-620
- ↵Richards TL, Dager SR, Panagiotides HS,, et al. Functional MR spectroscopy during language activation: a preliminary study using proton echo-planar spectroscopic imaging (PEPSI). . Int J Neuroradiol 1997;3:490-495
- ↵Posse S, Dager SR, Richards TL,, et al. In vivo measurement of regional brain metabolic response to hyperventilation using magnetic resonance proton echo planar spectroscopic imaging (PEPSI). . Magn Reson Med 1997;37:858-865
- ↵Eulitz C, Elbert T, Bartenstein P, Weiller C, Muller SP, Pantev C. Comparison of magnetic and metabolic brain activity during a verb generation task. . Neuroreport 1994;6:97-100
- ↵Binder JR, Frost JA, Hammeke TA, Cox RW, Rao SM, Prieto T. Human brain language areas identified by functional magnetic resonance imaging. . J Neurosci 1997;17:353-362
- ↵Frahm J, Krueger G, Merboldt KD, Kleinschmidt A. Dynamic NMR studies of perfusion and oxidative metabolism during focal brain activation. . Adv Exp Med Biol 1997;413:195-203
- ↵Hayes CE, Mathis CM. Improved brain coil for fMRI and high resolution imaging. . Presented at the annual meeting of the Society of Magnetic Resonance, Berkeley, CA, April, 1996;
- ↵Ojemann G. Localization of language in frontal cortex. . Adv Neurol 1992;57:361-368
- ↵Oldfield RC. The assessment and analysis of handedness: the Edinburgh Inventory. . Neuropsychologia 1971;9:97-113
- ↵Woodcock R. Woodcock Reading Mastery Test-Revised. . Minneapolis, MN: American Guidance Service; 1987;
- ↵Berninger V. Process Assessment of the Learner: Guides for Intervention. . San Antonio, TX: The Psychological Corporation; 1998;
- ↵Dager SR, Marro KI, Peterson J, Richards TL. Applications of magnetic resonance spectroscopy to investigate panic disorder. . In: Nasrallah H, Pettegrew J, eds NMR Spectroscopy in Psychiatric Brain Disorders. Washington, DC: American Psychiatric Press; 1995;147-177
- ↵Singh M. Toward proton MR spectroscopic imaging of stimulated brain function. . IEEE Trans Nucl Sci 1992;39:1161-1164
- ↵
- ↵Prichard JW. Nuclear magnetic resonance spectroscopy of seizure states. . Epilepsia 1994;35:S14-S20
- ↵Rumsey JM, Horwitz B, Donohue BC, Nace K, Maisog JM, Andreason P. Phonological and orthographic components of word recognition: a PET-rCBF study. . Brain 1997;120:739-759
- Lovett M, Ransby M, Hardwick N, Johns M, Donaldson S. Can dyslexia be treated? Treatment specific and generalized treatment effects in dyslexic children's response to remediation. . Brain Lang 1989;37:90-121
In this issue
Advertisement
Todd L. Richards, Stephen R. Dager, David Corina, Sandra Serafini, Aaron C. Heide, Keith Steury, Wayne Strauss, Cecil E. Hayes, Robert D. Abbott, Suzanne Craft, Dennis Shaw, Stefan Posse, Virginia W. Berninger
Dyslexic Children Have Abnormal Brain Lactate Response to Reading-Related Language Tasks
American Journal of Neuroradiology Sep 1999, 20 (8) 1393-1398;
0 Responses
Dyslexic Children Have Abnormal Brain Lactate Response to Reading-Related Language Tasks
Todd L. Richards, Stephen R. Dager, David Corina, Sandra Serafini, Aaron C. Heide, Keith Steury, Wayne Strauss, Cecil E. Hayes, Robert D. Abbott, Suzanne Craft, Dennis Shaw, Stefan Posse, Virginia W. Berninger
American Journal of Neuroradiology Sep 1999, 20 (8) 1393-1398;
Jump to section
Related Articles
- No related articles found.
Cited By...
This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.
More in this TOC Section
Similar Articles
Advertisement