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Research ArticlePediatric Neuroimaging

Dyslexic Children Have Abnormal Brain Lactate Response to Reading-Related Language Tasks

Todd L. Richards, Stephen R. Dager, David Corina, Sandra Serafini, Aaron C. Heide, Keith Steury, Wayne Strauss, Cecil E. Hayes, Robert D. Abbott, Suzanne Craft, Dennis Shaw, Stefan Posse and Virginia W. Berninger
American Journal of Neuroradiology September 1999, 20 (8) 1393-1398;
Todd L. Richards
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Stephen R. Dager
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David Corina
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Sandra Serafini
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Aaron C. Heide
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Keith Steury
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Wayne Strauss
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Cecil E. Hayes
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Robert D. Abbott
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Suzanne Craft
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Dennis Shaw
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Stefan Posse
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Virginia W. Berninger
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    fig 1.

    Bar graphs show number of activated voxels (as defined by MR spectroscopic lactate increases) in the four quadrants of the brain for both dyslexic and control children.

    A–C, Graphs of phonological task data (A), lexical access task (B), and tone task (C). (Error bars are standard error of the mean; asterisk indicates dyslexic versus control comparisons that were significantly different).

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    fig 2.

    MR image and proton spectra from an activated brain region of one dyslexic subject.

    A, MR image with white box indicating the brain region measured with MR spectroscopy.

    B, Proton MR spectrum from the white box brain region during the passive listening task.

    C, Proton MR spectrum from the white box brain region during the phonological task. The intensity axis of the spectra is scaled so that the lactate can be seen easier; however, choline (Cho) and NAA are scaled off the figure. Note the increase in the lactate peaks during the phonological task as compared with passive listening.

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American Journal of Neuroradiology
Vol. 20, Issue 8
1 Sep 1999
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Cite this article
Todd L. Richards, Stephen R. Dager, David Corina, Sandra Serafini, Aaron C. Heide, Keith Steury, Wayne Strauss, Cecil E. Hayes, Robert D. Abbott, Suzanne Craft, Dennis Shaw, Stefan Posse, Virginia W. Berninger
Dyslexic Children Have Abnormal Brain Lactate Response to Reading-Related Language Tasks
American Journal of Neuroradiology Sep 1999, 20 (8) 1393-1398;

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Dyslexic Children Have Abnormal Brain Lactate Response to Reading-Related Language Tasks
Todd L. Richards, Stephen R. Dager, David Corina, Sandra Serafini, Aaron C. Heide, Keith Steury, Wayne Strauss, Cecil E. Hayes, Robert D. Abbott, Suzanne Craft, Dennis Shaw, Stefan Posse, Virginia W. Berninger
American Journal of Neuroradiology Sep 1999, 20 (8) 1393-1398;
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  • Effects of a Phonologically Driven Treatment for Dyslexia on Lactate Levels Measured by Proton MR Spectroscopic Imaging
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