RT Journal Article
SR Electronic
T1 Dyslexic Children Have Abnormal Brain Lactate Response to Reading-Related Language Tasks
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1393
OP 1398
VO 20
IS 8
A1 Richards, Todd L.
A1 Dager, Stephen R.
A1 Corina, David
A1 Serafini, Sandra
A1 Heide, Aaron C.
A1 Steury, Keith
A1 Strauss, Wayne
A1 Hayes, Cecil E.
A1 Abbott, Robert D.
A1 Craft, Suzanne
A1 Shaw, Dennis
A1 Posse, Stefan
A1 Berninger, Virginia W.
YR 1999
UL http://www.ajnr.org/content/20/8/1393.abstract
AB BACKGROUND AND PURPOSE: Children with dyslexia have difficulty learning to recognize written words owing to subtle deficits in oral language related to processing sounds and accessing words automatically. The purpose of this study was to compare regional changes in brain lactate between dyslexic children and control subjects during oral language activation.METHODS: Brain lactate metabolism was measured during four different cognitive tasks (three language tasks and one nonlanguage task) in six dyslexic boys and in seven control subjects (age- and IQ-matched right-handed boys who are good readers) using a fast MR spectroscopic imaging technique called proton echo-planar spectroscopic imaging (1-cm3 voxel resolution). The area under the N-acetylaspartate (NAA) and lactate peaks was measured to calculate the lactate/NAA ratio in each voxel.RESULTS: Dyslexic boys showed a greater area of brain lactate elevation (2.33 ± SE 0.843 voxels) as compared with the control group (0.57 ± SE 0.30 voxels) during a phonological task in the left anterior quadrant. No significant differences were observed in the nonlanguage tasks.CONCLUSION: Dyslexic and control children differ in brain lactate metabolism when performing language tasks, but do not differ in nonlanguage auditory tasks.