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Research ArticleSpine Imaging and Spine Image-Guided Interventions

Enhancing Annular Fissures and High-Intensity Zones: Pain, Internal Derangement, and Anesthetic Response at Provocation Lumbar Discography

W.S. Bartynski, V. Agarwal, H. Trang, A.I. Bandos, W.E. Rothfus, J. Tsay, W.T. Delfyett and B. Nastasi
American Journal of Neuroradiology December 2022, DOI: https://doi.org/10.3174/ajnr.A7749
W.S. Bartynski
aFrom the Department of Radiology (W.S.B., V.A., H.T., W.E.R., J.T., W.T.D., B.N.), Division of Neuroradiology, University of Pittsburgh, Presbyterian University Hospital, Pittsburgh, Pennsylvania
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V. Agarwal
aFrom the Department of Radiology (W.S.B., V.A., H.T., W.E.R., J.T., W.T.D., B.N.), Division of Neuroradiology, University of Pittsburgh, Presbyterian University Hospital, Pittsburgh, Pennsylvania
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H. Trang
aFrom the Department of Radiology (W.S.B., V.A., H.T., W.E.R., J.T., W.T.D., B.N.), Division of Neuroradiology, University of Pittsburgh, Presbyterian University Hospital, Pittsburgh, Pennsylvania
bDepartment of Radiology (H.T.), St. Clair Hospital, Pittsburgh, Pennsylvania
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A.I. Bandos
cDepartment of Biostatistics (A.I.B.), Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania
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W.E. Rothfus
aFrom the Department of Radiology (W.S.B., V.A., H.T., W.E.R., J.T., W.T.D., B.N.), Division of Neuroradiology, University of Pittsburgh, Presbyterian University Hospital, Pittsburgh, Pennsylvania
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J. Tsay
aFrom the Department of Radiology (W.S.B., V.A., H.T., W.E.R., J.T., W.T.D., B.N.), Division of Neuroradiology, University of Pittsburgh, Presbyterian University Hospital, Pittsburgh, Pennsylvania
dDepartment of Radiology (J.T.), Cleveland Clinic, Cleveland, Ohio
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W.T. Delfyett
aFrom the Department of Radiology (W.S.B., V.A., H.T., W.E.R., J.T., W.T.D., B.N.), Division of Neuroradiology, University of Pittsburgh, Presbyterian University Hospital, Pittsburgh, Pennsylvania
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B. Nastasi
aFrom the Department of Radiology (W.S.B., V.A., H.T., W.E.R., J.T., W.T.D., B.N.), Division of Neuroradiology, University of Pittsburgh, Presbyterian University Hospital, Pittsburgh, Pennsylvania
eBrighton Radiology Associates, PC (B.N.), Monaca, Pennsylvania
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  • FIG 1.
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    FIG 1.

    T2-weighted sequence grading of annular fissures detected on postcontrast T1-weighted imaging. A, Grade 4 annular fissure: annular fissure signal has high signal intensity (arrow) with signal that is greater than that of adjacent spinal fluid, consistent with an HIZ. B, Enhancement in the Grade 4 annular fissure (arrow). C, Grade 3 annular fissure: annular fissure signal has high signal intensity (arrow) with signal that is less than that of the adjacent spinal fluid, consistent with an HIZ. D, Enhancement in the Grade 3 annular fissure (arrow). E, Grade 2 annular fissure: annular fissure signal is focally abnormal but with mixed intermediate-to-low signal intensity (arrow) appearing close to the signal of the degenerative disc without a definite HIZ. F, Enhancement in the Grade 2 annular fissure (arrow). G, Grade 1 annular fissure: annular fissure signal is abnormal and has low signal intensity (arrow), appearing similar to the signal of other portions of the severely degenerative disc. H, Enhancement in the Grade 1 annular fissure (arrow).

  • FIG 2.
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    FIG 2.

    Receiver operating curves (ROCs) for predicting concordant pain (A) and significant pain (B) based on HIZ and EAF features. Sens indicates sensitivity; Spec, specificity.

  • FIG 3.
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    FIG 3.

    A 49-year-old woman with long-standing LBP and some bilateral leg radiation (most severe VAS = 10/10; immediate preprocedural VAS = 5/10) with prior discectomy at L5–S1. Concordant pain was provoked at L2–3, L3–4, and L4–5, with all 3 levels demonstrating partial provoked pain improvement with intradiscal lidocaine, and all 3 levels appearing contained on postdiscogram CT. A, Sagittal postcontrast T1-weighted image demonstrates posterior EAFs at L2–3, L3–4 (thin arrows), and L4–5 (thick arrow). B, Sagittal T2-weighted image. The L2–3 HIZ, considered Grade 4, and L3–4 HIZ, considered Grade 2 by consensus group 1, were identified as HIZs by consensus group 2 (thin arrows). The EAF at L4–5 considered a Grade 1 HIZ by consensus group 1 was not identified as an HIZ by consensus group 2 (thick arrow). C, Sagittal reconstructed CT image demonstrates the posterior annular margin at L4–5, consistent with the EAF (thick arrow). D and E, Axial postdiscogram CT images through the L4–5 disc demonstrates severe annular degeneration (Dallas Grade 3) with the posterior annular margin noted, consistent with the EAF (thick arrow).

  • FIG 4.
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    FIG 4.

    A 29-year-old woman with complex LBP and leg pain (most severe VAS = 10/10; preprocedural VAS = 5/10) with prior L5–S1 discectomy. Concordant pain was provoked at L4–5 (VAS = 10/10). A, Sagittal T2-weighted sequence demonstrates a small annular fissure along the posterior annular margin (arrow), judged Grade 4 by consensus. B, Sagittal postcontrast T1-weighted sequence demonstrates enhancement in the annular fissure (arrow). C, Axial postdiscogram CT image demonstrates a full-thickness radial annular fissure (arrow) projecting into a small peripheral concentric annular fissure (arrowhead). D, Axial postdiscogram CT image demonstrates the posterior annular margin at the level of the peripheral concentric annular fissure (arrowhead), which corresponds to the HIZ identified on the T2-weighted sequence and EAF region demonstrated on the postcontrast T1-weighted sequence.

Tables

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    Table 1:

    Annular fissures identified and pain response at provocation discography

    Peripheral Annular Morphology by MR ImagingDiscography-Provoked Pain Response
    Severe PainNegative for PainTotal
    Concordant Pain(% of Total)Nonconcordant Pain(% of Total)
    EAF22/39 (56.4%)10/39 (25.6%)7/39 (18%)39 (100%)
    Focal high signal on T2WI only0011
    No MR imaging evidence of annular fissure/tear14/60 (23.3%)4/60 (6.7%)42/60 (70.0%)60 (100%)
    Total36/100 (36%)14/100 (14%)50/100 (50%)100 (100%)
    • View popup
    Table 2:

    Thirty-nine discs positive for EAF—T2WI grade, HIZ detection, and unrecognized fissure/tear pain response

    Annular Fissure/Tear CG-1 T2WI GradeEAFs Identified on T1 Enhanced Sequence by CG-1HIZs Identified on T2-Weighted Sequence by CG-2 (% EAFs)Injection Pain Response of 16 Unrecognized Annular Fissures (HIZs) by CG-2 on T2WI
    CNCN
    487/8 (87.5%)1
    31210/12 (83.3%)11
    284/8 (50.0%)121
    1112/11 (18.2%)711
    Total3923/39 (59.0%)943
    • Note:—C indicates concordant levels; NC, nonconcordant levels; N, negative pain response; CG-1, consensus group 1; CG-2, consensus group 2.

    • View popup
    Table 3:

    Proportions of discs with EAF for different pain responses by disc levels, sex, and patient age

    Disc/Patient CharacteristicsDiscography Pain Response
    Severe PainNegative for Pain (EAF %)Overall (EAF %)
    Concordant Pain (EAF %)Nonconcordant Pain (EAF %)
    Overall22/36 (61%)10/14 (71%)7/50 (14%)39/100 (39%)
    Disc level
     L1–2 to L2–3a2/3 (67%)0/1 (0%)1/9 (11%)3/13 (23%)
     L3–44/11 (36%)4/5 (80%)4/28 (14%)12/44 (27%)
     L4–514/15 (93%)3/3 (100%)2/10 (20%)19/28 (68%)
     L5–S12/7 (29%)3/5 (60%)0/3 (0%)5/15 (33%)
    Sex
     Female16/23 (70%)5/7 (71%)5/29 (17%)26/59 (44%)
     Male6/13 (46%)5/7 (71%)2/21 (10%)13/41 (32%)
    Age
     Younger than 41 yr16/24 (67%)7/9 (78%)6/25 (24%)29/58 (50%)
     41 yr or older6/12 (50%)3/5 (60%)1/25 (4%)10/42 (24%)
    • ↵a There was a single disc at L1–2 that did not have an EAF or pain on provocation.

    • View popup
    Table 4:

    Response to provocative discography by imaging findings of HIZ and EAF (no discs identified with HIZ but without EAF)

    Imaging FeaturesDiscography Pain Response
    Severe Pain (n = 50)Negative for Pain(n = 50)Total (n = 100)
    Concordant (n = 36)Nonconcordant (n = 14)
    EAF+ HIZ+14/36 (39%)6/14 (43%)3/50 (6%)23/100
    EAF+ HIZ−8/36 (22%)4/14 (29%)4/50 (8%)16/100
    EAF− HIZ−14/36 (39%)4/14 (29%)43/50 (86%)61/100
    Total36 (100%)14 (100%)50 (100%)100/100
    • View popup
    Table 5:

    Features of internal derangement—summary of all discs

    Disc StateDiscogram Pain Response
    Severe Pain
    ConcordantDiscordantNegative for PainTotal
    RDefDEGNlRDefDEGNlRDefDEGNlRDefDEGNlAll
    EAF913064a03401821039
    Focal high-signal T2 only0000000010011
    No annular fissure6532117b7c,d2815133260
    Total15183851101129333433100
    • Note:—Nl indicates normal-appearing disc on postdiscogram CT.

    • ↵a One Dallas Grade 1 disc.

    • ↵b One Dallas Grade 1 radial fissure.

    • ↵c One Dallas Grade 2 disc.

    • ↵d One Dallas Grade 1 disc; 1 Dallas Grade 2 disc.

    • View popup
    Table 6:

    EAF T2WI grade by CG-1 versus postdiscogram CT features of internal derangement—39 discs

    Annular Fissure T2WI CG-1 GradeDiscogram Pain Response and Internal Derangement Features
    Severe Pain
    Concordant PainNonconcordant PainNegative for PainTotal
    RDefDEGRDefDEGRDefDEGRDefDEG
    423300053
    342211275
    212121135
    12601a1138
    Total91364a341821
    • Note:—DEG indicates degenerative change Dallas Grade 3 except for 1 disc; RDef, all radial defects (Dallas Grade 3); CG-1, consensus group 1.

    • ↵a Dallas Grade 1.

    • View popup
    Table 7:

    Intradiscal lidocaine response—40 concordant and nonconcordant severely painful discs where anesthetic was injected

    Disc StateIntradiscal Lidocaine-Provoked Pain ResponseTotal (n = 40)
    Total Improvement (n = 17)Partial Improvement (n = 7)No Improvement (n = 16)
    Leaking14 (82%)2 (29%)5 (31%)21 (53%)
    Contained3 (18%)5 (71%)11 (69%)19 (48%)
    Total17 (100%)7 (100%)16 (100%)40 (100%)
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W.S. Bartynski, V. Agarwal, H. Trang, A.I. Bandos, W.E. Rothfus, J. Tsay, W.T. Delfyett, B. Nastasi
Enhancing Annular Fissures and High-Intensity Zones: Pain, Internal Derangement, and Anesthetic Response at Provocation Lumbar Discography
American Journal of Neuroradiology Dec 2022, DOI: 10.3174/ajnr.A7749

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Enhancing Annular Fissures and High-Intensity Zones: Pain, Internal Derangement, and Anesthetic Response at Provocation Lumbar Discography
W.S. Bartynski, V. Agarwal, H. Trang, A.I. Bandos, W.E. Rothfus, J. Tsay, W.T. Delfyett, B. Nastasi
American Journal of Neuroradiology Dec 2022, DOI: 10.3174/ajnr.A7749
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