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Case of the Week

Section Editors: Matylda Machnowska1 and Anvita Pauranik2
1University of Toronto, Toronto, Ontario, Canada
2BC Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada

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September 18, 2014

Pituitary Stone

  • Extensive calcification of the pituitary gland is rare.
  • The calcification varies in extent but rarely exceeds a tiny amount, histologically or radiologically. Generally classified as linear, capsular, or granular within the adenoma.
  • The endocrine function varies from normal to decreased secretion of Prolactin, GH, TSH, LH, and FSH.
  • Key Diagnostic Features:
    • Calcification on CT
    • Susceptibility on MRI
  • DDx:
    • Craniopharyngioma
    • Pituitary Tuberculosis
    • Meningioma
  • Rx: Surgical resection

Suggested Reading

Tamaki T, Takumi I, Kitamura T, et al. Pituitary stone. Neurol Med Chir (Tokyo) 2000;7:383–86, 10.2176/nmc.40.383

Webster J, Peters JR, John R, et al. Pituitary stone: two cases of densely calcified thyrotrophin-secreting pituitary adenomas. Clin Endocrinol (Oxf) 1994;40:137–43, 10.1111/j.1365-2265.1994.tb02456.x

Rasmussen C, Larsson SG, Bergh T. The occurrence of macroscopical pituitary calcifications in prolactinomas. Neuroradiology 1990;31:507–11, 10.1007/BF00340132

Sherman JL, Schnapf DJ, Coker SS. Computed tomography of a pituitary stone. J Comput Assist Tomogr 1983;7:1120–21

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