Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Getting new auth cookie, if you see this message a lot, tell someone!
Research ArticleAdult Brain
Open Access

Investigation of Brain Iron in Niemann-Pick Type C: A 7T Quantitative Susceptibility Mapping Study

P. Ravanfar, W.T. Syeda, R.J. Rushmore, B. Moffat, A.E. Lyall, A.H. Merritt, G.A. Devenyi, M.M. Chakravarty, P. Desmond, V.L. Cropley, N. Makris, M.E. Shenton, A.I. Bush, D. Velakoulis, C. Pantelis and M. Walterfang
American Journal of Neuroradiology July 2023, 44 (7) 768-775; DOI: https://doi.org/10.3174/ajnr.A7894
P. Ravanfar
aFrom Melbourne Neuropsychiatry Centre (P.R., W.T.S., A.H.M., V.L.C., D.V., C.P., M.W.), the Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia
bPsychiatry Neuroimaging Laboratory (P.R., R.J.R., A.E.L., N.M., M.E.S.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for P. Ravanfar
W.T. Syeda
aFrom Melbourne Neuropsychiatry Centre (P.R., W.T.S., A.H.M., V.L.C., D.V., C.P., M.W.), the Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for W.T. Syeda
R.J. Rushmore
bPsychiatry Neuroimaging Laboratory (P.R., R.J.R., A.E.L., N.M., M.E.S.)
eCenter for Morphometric Analysis (R.J.R., N.M.), Massachusetts General Hospital, Charlestown, Massachusetts
fDepartment of Anatomy and Neurobiology (R.J.R.), Boston University School of Medicine, Boston, Massachusetts
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for R.J. Rushmore
B. Moffat
gMelbourne Brain Centre Imaging Unit (B.M.), Department of Radiology, University of Melbourne, Parkville, Victoria, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for B. Moffat
A.E. Lyall
bPsychiatry Neuroimaging Laboratory (P.R., R.J.R., A.E.L., N.M., M.E.S.)
cDepartment of Psychiatry (A.E.L., M.E.S.)
hDepartment of Psychiatry (A.E.L., M.E.S.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A.E. Lyall
A.H. Merritt
aFrom Melbourne Neuropsychiatry Centre (P.R., W.T.S., A.H.M., V.L.C., D.V., C.P., M.W.), the Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A.H. Merritt
G.A. Devenyi
iCerebral Imaging Center (G.A.D., M.M.C.), Douglas Research Centre, Montreal, Quebec, Canada
jDepartments of Psychiatry (G.A.D., M.M.C.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for G.A. Devenyi
M.M. Chakravarty
iCerebral Imaging Center (G.A.D., M.M.C.), Douglas Research Centre, Montreal, Quebec, Canada
jDepartments of Psychiatry (G.A.D., M.M.C.)
kBiomedical Engineering (M.M.C.), McGill University, Montreal, Quebec, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M.M. Chakravarty
P. Desmond
lDepartments of Radiology (P.D.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for P. Desmond
V.L. Cropley
aFrom Melbourne Neuropsychiatry Centre (P.R., W.T.S., A.H.M., V.L.C., D.V., C.P., M.W.), the Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for V.L. Cropley
N. Makris
bPsychiatry Neuroimaging Laboratory (P.R., R.J.R., A.E.L., N.M., M.E.S.)
eCenter for Morphometric Analysis (R.J.R., N.M.), Massachusetts General Hospital, Charlestown, Massachusetts
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for N. Makris
M.E. Shenton
bPsychiatry Neuroimaging Laboratory (P.R., R.J.R., A.E.L., N.M., M.E.S.)
cDepartment of Psychiatry (A.E.L., M.E.S.)
dDepartment of Radiology (M.E.S.), Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts
hDepartment of Psychiatry (A.E.L., M.E.S.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M.E. Shenton
A.I. Bush
nMelbourne Dementia Research Centre (A.I.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A.I. Bush
D. Velakoulis
aFrom Melbourne Neuropsychiatry Centre (P.R., W.T.S., A.H.M., V.L.C., D.V., C.P., M.W.), the Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia
mNeuropsychiatry (D.V., M.W.), Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for D. Velakoulis
C. Pantelis
aFrom Melbourne Neuropsychiatry Centre (P.R., W.T.S., A.H.M., V.L.C., D.V., C.P., M.W.), the Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia
oThe Florey Institute of Neuroscience and Mental Health (C.P.), The University of Melbourne, Parkville, Victoria, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for C. Pantelis
M. Walterfang
aFrom Melbourne Neuropsychiatry Centre (P.R., W.T.S., A.H.M., V.L.C., D.V., C.P., M.W.), the Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia
mNeuropsychiatry (D.V., M.W.), Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M. Walterfang
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Rego T,
    2. Farrand S,
    3. Goh AM, et al
    . Psychiatric and cognitive symptoms associated with Niemann-Pick Type C disease: neurobiology and management. CNS Drugs 2019;33:125–42 doi:10.1007/s40263-018-0599-0 pmid:30632019
    CrossRefPubMed
  2. 2.↵
    1. Adibhatla RM,
    2. Hatcher JF
    . Lipid oxidation and peroxidation in CNS health and disease: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal 2010;12:125–69 doi:10.1089/ars.2009.2668 pmid:19624272
    CrossRefPubMedWeb of Science
  3. 3.↵
    1. Fu R,
    2. Yanjanin NM,
    3. Bianconi S, et al
    . Oxidative stress in Niemann-Pick disease, type C. Mol Genet Metab 2010;101:214–18 doi:10.1016/j.ymgme.2010.06.018 pmid:20667755
    CrossRefPubMed
  4. 4.↵
    1. Vázquez MC,
    2. Balboa E,
    3. Alvarez AR, et al
    . Oxidative stress: a pathogenic mechanism for Niemann-Pick Type C disease. Oxid Med Cell Longev 2012;2012:205713 doi:10.1155/2012/205713 pmid:22720116
    CrossRefPubMed
  5. 5.↵
    1. Walterfang M,
    2. Di Biase MA,
    3. Cropley VL, et al
    . Imaging of neuroinflammation in adult Niemann-Pick type C disease: a cross-sectional study. Neurology 2020;94:e1716–25 doi:10.1212/WNL.0000000000009287 pmid:32209649
    Abstract/FREE Full Text
  6. 6.↵
    1. Love S,
    2. Bridges LR,
    3. Case CP
    . Neurofibrillary tangles in Niemann-Pick disease type C. Brain J Neurol 1995;118:19–29 doi:10.1093/brain/118.1.119 pmid:7894998
    CrossRefPubMed
  7. 7.↵
    1. Suzuki K,
    2. Parker CC,
    3. Pentchev PG, et al
    . Neurofibrillary tangles in Niemann-Pick disease type C. Acta Neuropathol 1995;89:227–38 doi:10.1007/BF00309338 pmid:7754743
    CrossRefPubMed
  8. 8.↵
    1. Villemagne VL,
    2. Velakoulis D,
    3. Doré V, et al
    . Imaging of tau deposits in adults with Niemann-Pick type C disease: a case-control study. Eur J Nucl Med Mol Imaging 2019;46:1132–38 doi:10.1007/s00259-019-4273-7 pmid:30690666
    CrossRefPubMed
  9. 9.↵
    1. Hare D,
    2. Ayton S,
    3. Bush A, et al
    . A delicate balance: iron metabolism and diseases of the brain. Front Aging Neurosci 2013;5:34 doi:10.3389/fnagi.2013.00034 pmid:23874300
    CrossRefPubMed
  10. 10.↵
    1. Georgieff MK
    . The role of iron in neurodevelopment: fetal iron deficiency and the developing hippocampus. Biochem Soc Trans 2008;36:1267–71 doi:10.1042/BST0361267 pmid:19021538
    Abstract/FREE Full Text
  11. 11.↵
    1. Donley DW,
    2. Realing M,
    3. Gigley JP, et al
    . Iron activates microglia and directly stimulates indoleamine-2,3-dioxygenase activity in the N171-82Q mouse model of Huntington’s disease. PLoS One 2021;16:e0250606 doi:10.1371/journal.pone.0250606 pmid:33989290
    CrossRefPubMed
  12. 12.↵
    1. Nnah IC,
    2. Wessling-Resnick M
    . Brain iron homeostasis: a focus on microglial iron. Pharmaceuticals (Basel) 2018;11:129 doi:10.3390/ph11040129 pmid:30477086
    CrossRefPubMed
  13. 13.↵
    1. Ravanfar P,
    2. Loi SM,
    3. Syeda W, et al
    . Systematic review; quantitative susceptibility mapping (QSM) of brain iron profile in neurodegenerative diseases. Front Neurosci 2021;15:618435 doi:10.3389/fnins.2021.618435 pmid:33679303
    CrossRefPubMed
  14. 14.↵
    1. Christomanou H,
    2. Kellermann J,
    3. Linke RP, et al
    . Deficient ferritin immunoreactivity in visceral organs from four patients with Niemann-Pick disease type C. Biochem Mol Med 1995;55:105–15 doi:10.1006/bmme.1995.1040 pmid:7582867
    CrossRefPubMed
  15. 15.↵
    1. Christomanou H,
    2. Vanier MT,
    3. Santambrogio P, et al
    . Deficient ferritin immunoreactivity in tissues from Niemann-Pick type C patients: extension of findings to fetal tissues, H and L ferritin isoforms, but also one case of the rare Niemann-Pick C2 complementation group. Mol Genet Metab 2000;70:196–202 doi:10.1006/mgme.2000.3004 pmid:10924274
    CrossRefPubMedWeb of Science
  16. 16.↵
    1. Hung YH,
    2. Faux NG,
    3. Killilea DW, et al
    . Altered transition metal homeostasis in Niemann-Pick disease, type C1. Metallomics 2014;6:542–53 doi:10.1039/c3mt00308f pmid:24343124
    CrossRefPubMed
  17. 17.↵
    1. Ladd ME,
    2. Bachert P,
    3. Meyerspeer M, et al
    . Pros and cons of ultra-high-field MRI/MRS for human application. Prog Nucl Magn Reson Spectrosc 2018;109:1–50 doi:10.1016/j.pnmrs.2018.06.001 pmid:30527132
    CrossRefPubMed
  18. 18.↵
    1. Benussi A,
    2. Cotelli MS,
    3. Padovani A, et al
    . Recent neuroimaging, neurophysiological, and neuropathological advances for the understanding of NPC. F1000Res 2018;7:194 doi:10.12688/f1000research.12361.1 pmid:29511534
    CrossRefPubMed
  19. 19.↵
    1. Yushkevich PA,
    2. Piven J,
    3. Hazlett HC, et al
    . User-guided 3D active contour segmentation of anatomical structures: significantly improved efficiency and reliability. Neuroimage 2006;31:1116–28 doi:10.1016/j.neuroimage.2006.01.015 pmid:16545965
    CrossRefPubMedWeb of Science
  20. 20.↵
    1. Chakravarty MM,
    2. Steadman P,
    3. van Eede MC, et al
    . Performing label-fusion-based segmentation using multiple automatically generated templates. Hum Brain Mapp 2013;34:2635–54 doi:10.1002/hbm.22092 pmid:22611030
    CrossRefPubMedWeb of Science
  21. 21.↵
    1. Pauli WM,
    2. Nili AN,
    3. Tyszka JM
    . A high-resolution probabilistic in vivo atlas of human subcortical brain nuclei. Sci Data 2018;5:180063 doi:10.1038/sdata.2018.63 pmid:29664465
    CrossRefPubMed
  22. 22.↵
    1. Fedorov A,
    2. Beichel R,
    3. Kalpathy-Cramer J, et al
    . 3D Slicer as an image computing platform for the Quantitative Imaging Network. Magn Reson Imaging 2012;30:1323–41 doi:10.1016/j.mri.2012.05.001 pmid:22770690
    CrossRefPubMedWeb of Science
  23. 23.↵
    1. Yaghmaie N,
    2. Syeda WT,
    3. Wu C, et al
    . QSMART: quantitative susceptibility mapping artifact reduction technique. Neuroimage 2021;231:117701 doi:10.1016/j.neuroimage.2020.117701 pmid:33484853
    CrossRefPubMed
  24. 24.↵
    1. Jenkinson M,
    2. Beckmann CF,
    3. Behrens TE, et al
    . FSL. Neuroimage 2012;62:782–90 doi:10.1016/j.neuroimage.2011.09.015 pmid:21979382
    CrossRefPubMedWeb of Science
  25. 25.↵
    1. Li W,
    2. Wu B,
    3. Liu C
    . Quantitative susceptibility mapping of human brain reflects spatial variation in tissue composition. Neuroimage 2011;55:1645–56 doi:10.1016/j.neuroimage.2010.11.088 pmid:21224002
    CrossRefPubMedWeb of Science
  26. 26.↵
    1. Ng A,
    2. Johnston L,
    3. Chen Z, et al
    . Spatially dependent filtering for removing phase distortions at the cortical surface. Magn Reson Med 2011;66:784–93 doi:10.1002/mrm.22825 pmid:21394771
    CrossRefPubMed
  27. 27.↵
    1. Fazlollahi A,
    2. Ayton S,
    3. Bourgeat P, et al
    . A normalisation framework for quantitative brain imaging; application to quantitative susceptibility mapping. In: 2017 IEEE 14th International Symposium on Biomedical Imaging (ISBI 2017), Melbourne, Australia. April 18–21, 2017:97–100 doi:10.1109/ISBI.2017.7950477
    CrossRef
  28. 28.↵
    1. Avants BB,
    2. Tustison NJ,
    3. Song G, et al
    . A reproducible evaluation of ANTs similarity metric performance in brain image registration. Neuroimage 2011;54:2033–44 doi:10.1016/j.neuroimage.2010.09.025 pmid:20851191
    CrossRefPubMed
  29. 29.↵
    1. Iturriaga C,
    2. Pineda M,
    3. Fernández-Valero EM, et al
    . Niemann-Pick C disease in Spain: clinical spectrum and development of a disability scale. J Neurol Sci 2006;249:1–6 doi:10.1016/j.jns.2006.05.054 pmid:16814322
    CrossRefPubMedWeb of Science
  30. 30.↵
    1. Walterfang M,
    2. Siu R,
    3. Velakoulis D
    . The NUCOG: validity and reliability of a brief cognitive screening tool in neuropsychiatric patients. Aust N Z J Psychiatry 2006;40:995–1002 doi:10.1080/j.1440-1614.2006.01923.x pmid:17054568
    CrossRefPubMed
  31. 31.↵
    1. Rush AJ Jr.,
    2. First MB,
    3. Blacker D
    , eds. Handbook of Psychiatric Measures. 2nd ed. American Psychiatric Publishing; 2008:84–86
  32. 32.↵
    1. Smith SM,
    2. Nichols TE
    . Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. Neuroimage 2009;44:83–98 doi:10.1016/j.neuroimage.2008.03.061 pmid:18501637
    CrossRefPubMedWeb of Science
  33. 33.↵
    1. Winkler AM,
    2. Ridgway GR,
    3. Webster MA, et al
    . Permutation inference for the general linear model. Neuroimage 2014;92:381–97 doi:10.1016/j.neuroimage.2014.01.060 pmid:24530839
    CrossRefPubMed
  34. 34.↵
    1. Spence H,
    2. McNeil CJ,
    3. Waiter GD
    . The impact of brain iron accumulation on cognition: a systematic review. PLoS One 2020;15:e0240697 doi:10.1371/journal.pone.0240697 pmid:33057378
    CrossRefPubMed
  35. 35.↵
    1. Khattar N,
    2. Triebswetter C,
    3. Kiely M, et al
    . Investigation of the association between cerebral iron content and myelin content in normative aging using quantitative magnetic resonance neuroimaging. Neuroimage 2021;239:118267 doi:10.1016/j.neuroimage.2021.118267 pmid:34139358
    CrossRefPubMed
  36. 36.↵
    1. Benjamini Y,
    2. Hochberg Y
    . Controlling the false discovery rate: a practical and powerful approach to multiple testing. Royal Statistical Society: Series B (Methodological) 1995;57:289–300 doi:10.1111/j.2517-6161.1995.tb02031.x
    CrossRefPubMed
  37. 37.↵
    RStudio Team. RStudio: Integrated Development Environment for R. 2020. http://www.rstudio.com/. Accessed December 6, 2021
  38. 38.↵
    1. Revelle W
    . psych: Procedures for Psychological, Psychometric, and Personality Research. September 22, 2021. https://CRAN.R-project.org/package=psych. Accessed December 6, 2021
  39. 39.↵
    1. Wei T,
    2. Simko V,
    3. Levy M, et al
    . corrplot: Visualization of a Correlation Matrix. November 18, 2021. https://CRAN.R-project.org/package=corrplot. Accessed December 6, 2021
  40. 40.↵
    1. Conigrave J
    . corx: Create and Format Correlation Matrices. June 30, 2020. https://CRAN.R-project.org/package=corx. Accessed December 6, 2021
  41. 41.↵
    1. Wickham H,
    2. Averick M,
    3. Bryan J, et al
    . Welcome to the tidyverse. J Open Source Softw 2019;4:1686 doi:10.21105/joss.01686
    CrossRefPubMed
  42. 42.↵
    1. Wickham H,
    2. Bryan J
    . readxl: Read Excel Files. 2019. https://CRAN.R-project.org/package=readxl. Accessed December 6, 2021
  43. 43.↵
    1. Wickham H
    . ggplot2: Elegant Graphics for Data Analysis. 2016. https://ggplot2.tidyverse.org. Accessed December 6, 2021
  44. 44.↵
    1. Wickham H,
    2. François R,
    3. Henry L, et al
    . dplyr: A Grammar of Data Manipulation. 2021. https://CRAN.R-project.org/package=dplyr. Accessed December 6, 2021
  45. 45.↵
    1. Deistung A,
    2. Schweser F,
    3. Reichenbach JR
    . Overview of quantitative susceptibility mapping. NMR Biomed 2017;30:e3569 doi:10.1002/nbm.3569 pmid:27434134
    CrossRefPubMed
  46. 46.↵
    1. Langkammer C,
    2. Schweser F,
    3. Krebs N, et al
    . Quantitative susceptibility mapping (QSM) as a means to measure brain iron? A post mortem validation study. Neuroimage 2012;62:1593–99 doi:10.1016/j.neuroimage.2012.05.049 pmid:22634862
    CrossRefPubMed
  47. 47.↵
    1. Duyn JH,
    2. Schenck J
    . Contributions to magnetic susceptibility of brain tissue. NMR Biomed 2017;30:23546 doi:10.1002/nbm.3546
    CrossRef
  48. 48.↵
    1. Walterfang M,
    2. Patenaude B,
    3. Abel LA, et al
    . Subcortical volumetric reductions in adult Niemann-Pick disease type C: a cross-sectional study. AJNR Am J Neuroradiol 2013;34:1334–40 doi:10.3174/ajnr.A3356 pmid:23237858
    Abstract/FREE Full Text
  49. 49.↵
    1. Walterfang M,
    2. Fahey M,
    3. Desmond P, et al
    . White and gray matter alterations in adults with Niemann-Pick disease type C: a cross-sectional study. Neurology 2010;75:49–56 doi:10.1212/WNL.0b013e3181e6210e pmid:20484681
    Abstract/FREE Full Text
  50. 50.↵
    1. Benarroch EE
    . Pulvinar. Neurology 2015;84:738–47 doi:10.1212/WNL.0000000000001276 pmid:25609762
    Abstract/FREE Full Text
  51. 51.↵
    1. Salsano E,
    2. Umeh C,
    3. Rufa A, et al
    . Vertical supranuclear gaze palsy in Niemann-Pick type C disease. Neurol Sci 2012;33:1225–32 doi:10.1007/s10072-012-1155-1 pmid:22810120
    CrossRefPubMed
  52. 52.↵
    1. Reddy JV,
    2. Ganley IG,
    3. Pfeffer SR
    . Clues to neuro-degeneration in Niemann-Pick type C disease from global gene expression profiling. PLoS One 2006;1:e19 doi:10.1371/journal.pone.0000019 pmid:17183645
    CrossRefPubMed
  53. 53.↵
    1. Devos D,
    2. Cabantchik ZI,
    3. Moreau C, et al
    ; FAIRPARK-II and FAIRALS-II studygroups. Conservative iron chelation for neurodegenerative diseases such as Parkinson’s disease and amyotrophic lateral sclerosis. J Neural Transm (Vienna) 2020;127:189–203 doi:10.1007/s00702-019-02138-1 pmid:31912279
    CrossRefPubMed
  54. 54.↵
    1. Hung YH,
    2. Lotan A,
    3. Yeshurun S, et al
    . Iron chelation by deferiprone does not rescue the Niemann-Pick disease type C1 mouse model. Biometals 2020;33:87–95 doi:10.1007/s10534-020-00233-5 pmid:32100150
    CrossRefPubMed
  55. 55.↵
    1. Chen J,
    2. Gong NJ,
    3. Chaim KT, et al
    . Decompose quantitative susceptibility mapping (QSM) to sub-voxel diamagnetic and paramagnetic components based on gradient-echo MRI data. Neuroimage 2021;242:118477 doi:10.1016/j.neuroimage.2021.118477 pmid:34403742
    CrossRefPubMed
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 44 (7)
American Journal of Neuroradiology
Vol. 44, Issue 7
1 Jul 2023
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Investigation of Brain Iron in Niemann-Pick Type C: A 7T Quantitative Susceptibility Mapping Study
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
P. Ravanfar, W.T. Syeda, R.J. Rushmore, B. Moffat, A.E. Lyall, A.H. Merritt, G.A. Devenyi, M.M. Chakravarty, P. Desmond, V.L. Cropley, N. Makris, M.E. Shenton, A.I. Bush, D. Velakoulis, C. Pantelis, M. Walterfang
Investigation of Brain Iron in Niemann-Pick Type C: A 7T Quantitative Susceptibility Mapping Study
American Journal of Neuroradiology Jul 2023, 44 (7) 768-775; DOI: 10.3174/ajnr.A7894

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Brain Iron in Niemann-Pick Type C: 7T Study
P. Ravanfar, W.T. Syeda, R.J. Rushmore, B. Moffat, A.E. Lyall, A.H. Merritt, G.A. Devenyi, M.M. Chakravarty, P. Desmond, V.L. Cropley, N. Makris, M.E. Shenton, A.I. Bush, D. Velakoulis, C. Pantelis, M. Walterfang
American Journal of Neuroradiology Jul 2023, 44 (7) 768-775; DOI: 10.3174/ajnr.A7894
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSIONS
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

Adult Brain

  • Diagnostic Neuroradiology of Monoclonal Antibodies
  • NCCT vs. MRI for Brain Atrophy in Acute Stroke
  • Clinical Outcomes After Chiari I Decompression
Show more Adult Brain

Functional

  • Kurtosis and Epileptogenic Tubers: A Pilot Study
  • Glutaric Aciduria Type 1: DK vs. Conventional MRI
  • Multiparametric MRI in PEDS Pontine Glioma
Show more Functional

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire