Article Figures & Data
Figures
- FIG 1.
Reconstruction of structural brain connectivity networks. A, Cortical and subcortical GM was parcellated into 164 regions based on the T1-weighted images. B, Constrained spherical deconvolution was used to estimate complex fiber orientation distributions from diffusion MR imaging data. C, Whole-brain probabilistic streamline tractography was performed to reconstruct (D) structural brain connectivity networks, in which nodes represent GM regions and the edges between the nodes represent the WM connectivity (number of streamlines) between the regions. The size of the nodes corresponds to the strength of the node, and the opacity of the edges is scaled according to the number of streamlines. The fiber orientation distributions and whole-brain tractography are colored according to the directions in the brain: red (left-right), blue (superior-inferior), and green (anterior-posterior).
- FIG 2.
Global graph theoretical properties of the structural brain connectivity networks in patients with AGU and control subjects. The violin plots show the full distribution of the data via kernel density plots.
- FIG 3.
Correlation of the global network properties with age in patients with AGU and control subjects. The shaded area shows the 95% confidence interval for the regression lines.
- FIG 4.
Local alterations in the strength of the structural brain connectivity networks in AGU compared with control subjects. Decreased strength of the structural brain connectivity networks in AGU compared with control subjects was found in 11 nodes (Online Supplemental Data), shown in yellow: 1) right middle temporal gyrus, 2) right putamen, 3) right thalamus, 4) right middle occipital gyrus, 5) left middle temporal gyrus, 6) right occipital pole, 7) right superior occipital gyrus, 8) left planum temporale, 9) left precentral gyrus, 10) right transverse temporal gyrus, and 11) left lingual gyrus. These results endured the Bonferroni correction for multiple comparisons. The size of the nodes corresponds to their strength. The complete results are presented in the Online Supplemental Data.
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