Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleAdult Brain

Topological Structural Brain Connectivity Alterations in Aspartylglucosaminuria: A Case-Control Study

U. Roine, A.M. Tokola, T. Autti and T. Roine
American Journal of Neuroradiology January 2023, 44 (1) 40-46; DOI: https://doi.org/10.3174/ajnr.A7745
U. Roine
aFrom the Department of Radiology (U.R., A.M.T., T.A., T.R.), HUS Medical Imaging Center
bDepartment of Pediatric Neurology (U.R.), Children’s Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for U. Roine
A.M. Tokola
aFrom the Department of Radiology (U.R., A.M.T., T.A., T.R.), HUS Medical Imaging Center
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A.M. Tokola
T. Autti
aFrom the Department of Radiology (U.R., A.M.T., T.A., T.R.), HUS Medical Imaging Center
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for T. Autti
T. Roine
aFrom the Department of Radiology (U.R., A.M.T., T.A., T.R.), HUS Medical Imaging Center
cDepartment of Neuroscience and Biomedical Engineering (T.R.), Aalto University School of Science, Espoo, Finland
dTurku Brain and Mind Center (T.R.), University of Turku, Turku, Finland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for T. Roine
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

Article Figures & Data

Figures

  • FIG 1.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIG 1.

    Reconstruction of structural brain connectivity networks. A, Cortical and subcortical GM was parcellated into 164 regions based on the T1-weighted images. B, Constrained spherical deconvolution was used to estimate complex fiber orientation distributions from diffusion MR imaging data. C, Whole-brain probabilistic streamline tractography was performed to reconstruct (D) structural brain connectivity networks, in which nodes represent GM regions and the edges between the nodes represent the WM connectivity (number of streamlines) between the regions. The size of the nodes corresponds to the strength of the node, and the opacity of the edges is scaled according to the number of streamlines. The fiber orientation distributions and whole-brain tractography are colored according to the directions in the brain: red (left-right), blue (superior-inferior), and green (anterior-posterior).

  • FIG 2.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIG 2.

    Global graph theoretical properties of the structural brain connectivity networks in patients with AGU and control subjects. The violin plots show the full distribution of the data via kernel density plots.

  • FIG 3.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIG 3.

    Correlation of the global network properties with age in patients with AGU and control subjects. The shaded area shows the 95% confidence interval for the regression lines.

  • FIG 4.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIG 4.

    Local alterations in the strength of the structural brain connectivity networks in AGU compared with control subjects. Decreased strength of the structural brain connectivity networks in AGU compared with control subjects was found in 11 nodes (Online Supplemental Data), shown in yellow: 1) right middle temporal gyrus, 2) right putamen, 3) right thalamus, 4) right middle occipital gyrus, 5) left middle temporal gyrus, 6) right occipital pole, 7) right superior occipital gyrus, 8) left planum temporale, 9) left precentral gyrus, 10) right transverse temporal gyrus, and 11) left lingual gyrus. These results endured the Bonferroni correction for multiple comparisons. The size of the nodes corresponds to their strength. The complete results are presented in the Online Supplemental Data.

PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 44 (1)
American Journal of Neuroradiology
Vol. 44, Issue 1
1 Jan 2023
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Topological Structural Brain Connectivity Alterations in Aspartylglucosaminuria: A Case-Control Study
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
U. Roine, A.M. Tokola, T. Autti, T. Roine
Topological Structural Brain Connectivity Alterations in Aspartylglucosaminuria: A Case-Control Study
American Journal of Neuroradiology Jan 2023, 44 (1) 40-46; DOI: 10.3174/ajnr.A7745

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Brain Connectivity in Aspartylglucosaminuria
U. Roine, A.M. Tokola, T. Autti, T. Roine
American Journal of Neuroradiology Jan 2023, 44 (1) 40-46; DOI: 10.3174/ajnr.A7745
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATION:
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSIONS
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

Adult Brain

  • Diagnostic Neuroradiology of Monoclonal Antibodies
  • NCCT vs. MRI for Brain Atrophy in Acute Stroke
  • Clinical Outcomes After Chiari I Decompression
Show more Adult Brain

Functional

  • Kurtosis and Epileptogenic Tubers: A Pilot Study
  • Glutaric Aciduria Type 1: DK vs. Conventional MRI
  • Multiparametric MRI in PEDS Pontine Glioma
Show more Functional

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire