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Research ArticlePediatric Neuroimaging

MR Imaging of Pediatric Low-Grade Gliomas: Pretherapeutic Differentiation of BRAF V600E Mutation, BRAF Fusion, and Wild-Type Tumors in Patients without Neurofibromatosis-1

A. Trasolini, C. Erker, S. Cheng, C. Crowell, K. McFadden, R. Moineddin, M.A. Sargent and D. Mata-Mbemba
American Journal of Neuroradiology August 2022, 43 (8) 1196-1201; DOI: https://doi.org/10.3174/ajnr.A7574
A. Trasolini
aFrom the IWK Health Centre (A.T., C.E., C.C., K.M., D.M.-M.), Halifax, Nova Scotia, Canada
bDalhousie University Medical School (A.T.), Halifax, Nova Scotia, Canada
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C. Erker
aFrom the IWK Health Centre (A.T., C.E., C.C., K.M., D.M.-M.), Halifax, Nova Scotia, Canada
cDepartments of Pediatrics (C.E.)
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S. Cheng
gDivision of Hematology, Oncology, and Bone Marrow Transplant (S.C.), Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada
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C. Crowell
aFrom the IWK Health Centre (A.T., C.E., C.C., K.M., D.M.-M.), Halifax, Nova Scotia, Canada
fFaculty of Science (C.C.), Dalhousie University, Halifax, Nova Scotia, Canada
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K. McFadden
aFrom the IWK Health Centre (A.T., C.E., C.C., K.M., D.M.-M.), Halifax, Nova Scotia, Canada
dPathology (K.M.)
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R. Moineddin
hUniversity of Toronto Dalla Lana School of Public Health (R.M.), Toronto, Ontario, Canada
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M.A. Sargent
iDepartment of Radiology (M.A.S.), British Columbia Children’s Hospital and University of British Columbia, Vancouver, British Columbia, Canada
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D. Mata-Mbemba
aFrom the IWK Health Centre (A.T., C.E., C.C., K.M., D.M.-M.), Halifax, Nova Scotia, Canada
eDiagnostic Radiology (D.M.-M.)
jDepartment of Diagnostic Imaging (D.M.-M.), IWK Health Centre, Halifax, Nova Scotia, Canada
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Article Information

vol. 43 no. 8 1196-1201
DOI 
https://doi.org/10.3174/ajnr.A7574
PubMed 
35863783

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received February 9, 2022
  • Accepted after revision May 24, 2022
  • Published online August 8, 2022.

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  • Latest version (July 21, 2022 - 06:46).
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© 2022 by American Journal of Neuroradiology

Author Information

  1. A. Trasolinia,b,
  2. C. Erkera,c,
  3. S. Chengg,
  4. C. Crowella,f,
  5. K. McFaddena,d,
  6. R. Moineddinh,
  7. M.A. Sargenti and
  8. D. Mata-Mbembaa,e,j
  1. aFrom the IWK Health Centre (A.T., C.E., C.C., K.M., D.M.-M.), Halifax, Nova Scotia, Canada
  2. bDalhousie University Medical School (A.T.), Halifax, Nova Scotia, Canada
  3. cDepartments of Pediatrics (C.E.)
  4. dPathology (K.M.)
  5. eDiagnostic Radiology (D.M.-M.)
  6. fFaculty of Science (C.C.), Dalhousie University, Halifax, Nova Scotia, Canada
  7. gDivision of Hematology, Oncology, and Bone Marrow Transplant (S.C.), Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada
  8. hUniversity of Toronto Dalla Lana School of Public Health (R.M.), Toronto, Ontario, Canada
  9. iDepartment of Radiology (M.A.S.), British Columbia Children’s Hospital and University of British Columbia, Vancouver, British Columbia, Canada
  10. jDepartment of Diagnostic Imaging (D.M.-M.), IWK Health Centre, Halifax, Nova Scotia, Canada
  1. Please address correspondence to Daddy Mata-Mbemba, MD, PhD, Department of Diagnostic Imaging, IWK Health Centre & Department of Diagnostic Radiology, Dalhousie University. 5850/5980 University Ave, PO Box 9700, Halifax, NS B3K 6R8; e-mail: Daddy.Mata-Mbemba{at}iwk.nshealth.ca; @matadaddy
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  • IWK Health Centre

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American Journal of Neuroradiology: 43 (8)
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Cite this article
A. Trasolini, C. Erker, S. Cheng, C. Crowell, K. McFadden, R. Moineddin, M.A. Sargent, D. Mata-Mbemba
MR Imaging of Pediatric Low-Grade Gliomas: Pretherapeutic Differentiation of BRAF V600E Mutation, BRAF Fusion, and Wild-Type Tumors in Patients without Neurofibromatosis-1
American Journal of Neuroradiology Aug 2022, 43 (8) 1196-1201; DOI: 10.3174/ajnr.A7574

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MRI of PEDS Low-Grade Gliomas and BRAF
A. Trasolini, C. Erker, S. Cheng, C. Crowell, K. McFadden, R. Moineddin, M.A. Sargent, D. Mata-Mbemba
American Journal of Neuroradiology Aug 2022, 43 (8) 1196-1201; DOI: 10.3174/ajnr.A7574
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Cited By...

  • Imaging Clusters of Pediatric Low-Grade Glioma Are Associated with Distinct Molecular Characteristics
  • CNS Embryonal Tumor with PLAGL Amplification, a New Tumor in Children and Adolescents: Insights from a Comprehensive MRI Analysis
  • Multiparametric MRI Along with Machine Learning Informs on Molecular Underpinnings, Prognosis, and Treatment Response in Pediatric Low-Grade Glioma
  • Imaging Clusters of Pediatric Low-Grade Glioma are Associated with Distinct Molecular Characteristics
  • Identification of Multiclass Pediatric Low-Grade Neuroepithelial Tumor Molecular Subtype with ADC MR Imaging and Machine Learning
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