Article Figures & Data
Figures
- FIG 1.
Upper row: QSM showing 2 HC (A and B) and 2 subjects with HH (C and D). Lower row: Corresponding R2* maps. Elevated striatal and PT iron is depicted in both subjects with HH (C and D, F and G). For 1 subject (C and F), high iron can be seen in the cuneus and striatal cortex.
- FIG 2.
Comparison of susceptibility (parts per billion) between patients with HH and HC. Asterisk indicates P < .05; double asterisks, P < .01; triple asterisks, P < .001.
- FIG 3.
Comparison of R2* (s−1) between patients with HH and HC. Double asterisks indicate P < .01; triple asterisks, P < .001.
Tables
Subjects with HH
(n = 52)No. Mean Age (yr) 95% CI P Value Men HH 30 58.23 (SD, 12.29) –12.29–2.52 .19 HC 19 53.32 (SD, 12.82) Women HH 22 58.00 (SD, 14.91) –11.59–4.52 .38 HC 28 54.46 (SD, 13.38) Demographics of Patients with HH Age at HH diagnosis (mean) (yr) 51.09 (SD, 12.92) (n = 52) Handedness Right: 50, left: 2 Family history of HH Yes: 30, no: 21, unknown: 1 Average duration from time of diagnosis to MR imaging (yr) 7.29 (SD, 5.22) (n = 51) Genetic diagnosis (n = 60) C282Y homozygous: 41 H63D homozygous: 2 C282Y heterozygous: 2 H63D heterozygous: 1 Compound heterozygous: 3 Unknown status: 3 - Table 3:
Comparative analysis of mean susceptibility (parts per billion) in the DGM nuclei between patients with HH and HCa
Group Statistics T Test for Equality of Means Structure Diagnosis No. Mean SD Standard Error of the Mean t df Significant (2-Tailed) Mean Difference Standard Error Difference 95% CI of the Difference Lower Upper CN HC 47 24.43 8.7 1.3 −2.08 97 .040a −6.86 3.30 −13.41 −0.31 HH 52 31.29 21.0 2.9 GP HC 47 85.48 20.1 2.9 1.09 97 .278 4.57 4.19 −3.74 12.89 HH 52 80.91 21.4 3.0 PUT HC 47 33.06 14.4 2.1 −3.37 97 .001b −19.63 5.83 −31.20 −8.07 HH 52 52.70 37.5 5.2 THA HC 47 3.45 3.6 0.5 −1.78 97 .079 −1.58 0.89 −3.36 0.19 HH 52 5.04 5.1 0.7 PT HC 47 36.40 13.5 2.0 −2.66 97 .009b −9.79 3.68 −17.09 −2.48 HH 52 46.19 21.7 3.0 RN HC 47 94.91 24.1 3.5 −4.32 97 <.001c −23.40 5.41 −34.15 −12.66 HH 52 118.32 29.2 4.1 SN HC 47 129.69 22.8 3.3 −2.26 97 .026a −11.66 5.15 −21.88 −1.43 HH 52 141.35 27.9 3.9 DN HC 47 92.53 24.2 3.5 −5.10 97 <.001c −32.09 6.30 44.59 −19.59 HH 52 124.62 36.5 5.1 - Table 4:
Comparative analysis of R2* (s−1) in the deep gray matter nuclei between subjects with HH and HC
Group Statistics T Test for Equality of Means Structure Diagnosis No. Mean SD Standard Error of the Mean t df Significant (2-Tailed) Mean Difference Standard Error Difference 95% Confidence Interval of the Difference Lower Upper CN HC 47 25.23 3.0 0.4 2.89 97 .005a −2.94 1.02 −4.95 −0.92 HH 52 28.17 6.3 0.9 GP HC 47 40.12 4.6 0.7 1.88 97 .064 −2.22 1.18 −4.57 0.13 HH 52 42.35 6.8 0.9 PUT HC 47 29.67 4.9 0.7 4.19 97 <.001b −5.98 1.43 −8.81 −3.15 HH 52 35.65 8.6 1.2 THA HC 47 21.01 1.5 0.2 −3.59 97 .001a −1.31 0.37 −2.04 −0.59 HH 52 22.32 2.1 0.3 PT HC 47 24.15 3.0 0.4 −4.36 97 <.001b −3.20 0.73 −4.66 −1.74 HH 52 27.35 4.2 0.6 RN HC 47 36.26 5.3 0.8 −2.65 97 .009a −3.46 1.31 −6.05 −0.87 HH 52 39.72 7.4 1.0 SN HC 47 36.60 4.5 0.7 −1.94 97 .056 −2.02 1.04 -4.08 0.05 HH 52 38.62 5.7 0.8 DN HC 47 32.23 5.2 0.8 −3.95 97 <.001b −6.28 1.59 −9.43 −3.13 HH 52 38.50 9.7 1.3
