Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleSpine Imaging and Spine Image-Guided Interventions

Spine MRI in Spontaneous Intracranial Hypotension for CSF Leak Detection: Nonsuperiority of Intrathecal Gadolinium to Heavily T2-Weighted Fat-Saturated Sequences

T. Dobrocky, A. Winklehner, P.S. Breiding, L. Grunder, G. Peschi, L. Häni, P.J. Mosimann, M. Branca, J. Kaesmacher, P. Mordasini, A. Raabe, C.T. Ulrich, J. Beck, J. Gralla and E.I. Piechowiak
American Journal of Neuroradiology July 2020, 41 (7) 1309-1315; DOI: https://doi.org/10.3174/ajnr.A6592
T. Dobrocky
aFrom the University Institute of Diagnostic and Interventional Neuroradiology (T.D., A.W., P.S.B., L.G., G.P., P.J.M., J.K., P.M., J.G., E.I.P.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for T. Dobrocky
A. Winklehner
aFrom the University Institute of Diagnostic and Interventional Neuroradiology (T.D., A.W., P.S.B., L.G., G.P., P.J.M., J.K., P.M., J.G., E.I.P.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A. Winklehner
P.S. Breiding
aFrom the University Institute of Diagnostic and Interventional Neuroradiology (T.D., A.W., P.S.B., L.G., G.P., P.J.M., J.K., P.M., J.G., E.I.P.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for P.S. Breiding
L. Grunder
aFrom the University Institute of Diagnostic and Interventional Neuroradiology (T.D., A.W., P.S.B., L.G., G.P., P.J.M., J.K., P.M., J.G., E.I.P.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for L. Grunder
G. Peschi
aFrom the University Institute of Diagnostic and Interventional Neuroradiology (T.D., A.W., P.S.B., L.G., G.P., P.J.M., J.K., P.M., J.G., E.I.P.)
bDepartment of Interventional, Pediatric, and Diagnostic Radiology (G.P., J.K.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for G. Peschi
L. Häni
cNeurosurgery (L.H., A.R., C.T.U., J.B.), University of Bern, Inselspital, Bern, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for L. Häni
P.J. Mosimann
aFrom the University Institute of Diagnostic and Interventional Neuroradiology (T.D., A.W., P.S.B., L.G., G.P., P.J.M., J.K., P.M., J.G., E.I.P.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for P.J. Mosimann
M. Branca
dClinical Trials Unit (M.B.), University of Bern, Bern, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M. Branca
J. Kaesmacher
aFrom the University Institute of Diagnostic and Interventional Neuroradiology (T.D., A.W., P.S.B., L.G., G.P., P.J.M., J.K., P.M., J.G., E.I.P.)
bDepartment of Interventional, Pediatric, and Diagnostic Radiology (G.P., J.K.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J. Kaesmacher
P. Mordasini
aFrom the University Institute of Diagnostic and Interventional Neuroradiology (T.D., A.W., P.S.B., L.G., G.P., P.J.M., J.K., P.M., J.G., E.I.P.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for P. Mordasini
A. Raabe
cNeurosurgery (L.H., A.R., C.T.U., J.B.), University of Bern, Inselspital, Bern, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A. Raabe
C.T. Ulrich
cNeurosurgery (L.H., A.R., C.T.U., J.B.), University of Bern, Inselspital, Bern, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for C.T. Ulrich
J. Beck
cNeurosurgery (L.H., A.R., C.T.U., J.B.), University of Bern, Inselspital, Bern, Switzerland
eDepartment of Neurosurgery (J.B.), Medical Center, University of Freiburg, Freiburg, Germany.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J. Beck
J. Gralla
aFrom the University Institute of Diagnostic and Interventional Neuroradiology (T.D., A.W., P.S.B., L.G., G.P., P.J.M., J.K., P.M., J.G., E.I.P.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J. Gralla
E.I. Piechowiak
aFrom the University Institute of Diagnostic and Interventional Neuroradiology (T.D., A.W., P.S.B., L.G., G.P., P.J.M., J.K., P.M., J.G., E.I.P.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for E.I. Piechowiak
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Beck J,
    2. Ulrich CT,
    3. Fung C, et al
    . Diskogenic microspurs as a major cause of intractable spontaneous intracranial hypotension. Neurology 2016;87:1220–26 doi:10.1212/WNL.0000000000003122 pmid:27566748
    Abstract/FREE Full Text
  2. 2.↵
    1. Schievink WI
    . Spontaneous spinal cerebrospinal fluid leaks: a review. Neurosurg Focus 2000;9:e8 doi:10.3171/foc.2000.9.1.8 pmid:16859269
    CrossRefPubMed
  3. 3.↵
    1. Schievink WI,
    2. Moser FG,
    3. Maya MM
    . CSF-venous fistula in spontaneous intracranial hypotension. Neurology 2014;83:472–73 doi:10.1212/WNL.0000000000000639 pmid:24951475
    Abstract/FREE Full Text
  4. 4.↵
    1. Kranz PG,
    2. Luetmer PH,
    3. Diehn FE, et al
    . Myelographic techniques for the detection of spinal CSF leaks in spontaneous intracranial hypotension. AJR Am J Roentgenol 2016;206:8–19 doi:10.2214/AJR.15.14884 pmid:26700332
    CrossRefPubMed
  5. 5.↵
    1. Chazen JL,
    2. Talbott JF,
    3. Lantos JE, et al
    . MR myelography for identification of spinal CSF leak in spontaneous intracranial hypotension. AJNR Am J Neuroradiol 2014;35:2007–12 doi:10.3174/ajnr.A3975 pmid:24852289
    Abstract/FREE Full Text
  6. 6.↵
    1. Dobrocky T,
    2. Mosimann PJ,
    3. Zibold F, et al
    . Cryptogenic cerebrospinal fluid leaks in spontaneous intracranial hypotension: role of dynamic CT myelography. Radiology 2018;289:766–72 doi:10.1148/radiol.2018180732 pmid:30226459
    CrossRefPubMed
  7. 7.↵
    1. Morioka T,
    2. Aoki T,
    3. Tomoda Y, et al
    . Cerebrospinal fluid leakage in intracranial hypotension syndrome: usefulness of indirect findings in radionuclide cisternography for detection and treatment monitoring. Clin Nucl Med 2008;33:181–85 doi:10.1097/RLU.0b013e318162d955 pmid:18287840
    CrossRefPubMedWeb of Science
  8. 8.↵
    1. Starling A,
    2. Hernandez F,
    3. Hoxworth JM, et al
    . Sensitivity of MRI of the spine compared with CT myelography in orthostatic headache with CSF leak. Neurology 2013;81:1789–92 doi:10.1212/01.wnl.0000435555.13695.22 pmid:24107860
    Abstract/FREE Full Text
  9. 9.↵
    1. Watanabe A,
    2. Horikoshi T,
    3. Uchida M, et al
    . Diagnostic value of spinal MR imaging in spontaneous intracranial hypotension syndrome. AJNR Am J Neuroradiol 2009;30:147–51 doi:10.3174/ajnr.A1277 pmid:18768717
    Abstract/FREE Full Text
  10. 10.↵
    1. Zeng Q,
    2. Xiong L,
    3. Jinkins JR, et al
    . Intrathecal gadolinium-enhanced MR myelography and cisternography: a pilot study in human patients. AJR Am J Roentgenol 1999;173:1109–15 doi:10.2214/ajr.173.4.10511188 pmid:10511188
    CrossRefPubMed
  11. 11.↵
    1. Beck J,
    2. Fung C,
    3. Ulrich CT, et al
    . Cerebrospinal fluid outflow resistance as a diagnostic marker of spontaneous cerebrospinal fluid leakage. J Neurosurg Spine 2017;27:227–34 doi:10.3171/2017.1.SPINE16548 pmid:28574328
    CrossRefPubMed
  12. 12.↵
    1. Fichtner J,
    2. Ulrich CT,
    3. Fung C, et al
    . Sonography of the optic nerve sheath diameter before and after microsurgical closure of a dural CSF fistula in patients with spontaneous intracranial hypotension: a consecutive cohort study. Cephalalgia 2018;39:306–15 doi:10.1177/0333102418793640 pmid:30099952
    CrossRefPubMed
  13. 13.↵
    1. Fichtner J,
    2. Ulrich CT,
    3. Fung C, et al
    . Management of spontaneous intracranial hypotension: transorbital ultrasound as discriminator. J Neurol Neurosurg Psychiatry 2016;87:650–65 doi:10.1136/jnnp-2015-310853 pmid:26285586
    Abstract/FREE Full Text
  14. 14.↵
    1. Dobrocky T,
    2. Grunder L,
    3. Breiding PS, et al
    . Assessing spinal cerebrospinal fluid leaks in spontaneous intracranial hypotension with a scoring system based on brain magnetic resonance imaging findings. JAMA Neurol 2019;76:580–87 doi:10.1001/jamaneurol.2018.4921 pmid:30776059
    CrossRefPubMed
  15. 15.↵
    1. Kranz PG,
    2. Amrhein TJ,
    3. Gray L
    . CSF venous fistulas in spontaneous intracranial hypotension: imaging characteristics on dynamic and CT myelography. Am J Roentgenol 2017;209:1360–66 doi:10.2214/AJR.17.18351 pmid:29023155
    CrossRefPubMed
  16. 16.↵
    1. Beck J,
    2. Raabe A,
    3. Schievink WI, et al
    . Posterior approach and spinal cord release for 360° repair of dural defects in spontaneous intracranial hypotension. Neurosurgery 2019;84:E345–51 doi:10.1093/neuros/nyy312 pmid:30053151
    CrossRefPubMed
  17. 17.↵
    1. Tomoda Y,
    2. Korogi Y,
    3. Aoki T, et al
    . Detection of cerebrospinal fluid leakage: initial experience with three-dimensional fast spin-echo magnetic resonance myelography. Acta Radiol 2008;49:197–203 doi:10.1080/02841850701769785 pmid:18300147
    CrossRefPubMedWeb of Science
  18. 18.↵
    1. Schumacher M,
    2. Kraemer N,
    3. Berlis A
    . Intrathecal gadolinium-enhanced MR myelography showing multiple dural leakages in a patient with Marfan syndrome. AJR Am J Roentgenol 2005;185:92–94 doi:10.2214/ajr.185.1.01850092 pmid:15972406
    CrossRefPubMedWeb of Science
  19. 19.↵
    1. Akbar JJ,
    2. Luetmer PH,
    3. Schwartz KM, et al
    . The role of MR myelography with intrathecal gadolinium in localization of spinal CSF leaks in patients with spontaneous intracranial hypotension. AJNR Am J Neuroradiol 2012;33:535–40 doi:10.3174/ajnr.A2815 pmid:22173753
    Abstract/FREE Full Text
  20. 20.↵
    1. Hoxworth JM,
    2. Patel AC,
    3. Bosch EP, et al
    . Localization of a rapid CSF leak with digital subtraction myelography. AJNR Am J Neuroradiol 2009;30:516–19 doi:10.3174/ajnr.A1294 pmid:18842766
    Abstract/FREE Full Text
  21. 21.↵
    1. Schievink WI,
    2. Maya MM,
    3. Chu RM, et al
    . False localizing sign of cervico-thoracic CSF leak in spontaneous intracranial hypotension. Neurology 2015;84:2445–48 doi:10.1212/WNL.0000000000001697 pmid:25979700
    Abstract/FREE Full Text
  22. 22.↵
    1. Albayram S,
    2. Kilic F,
    3. Ozer H, et al
    . Gadolinium-enhanced MR cisternography to evaluate dural leaks in intracranial hypotension syndrome. AJNR Am J Neuroradiol 2008;29:116–21 doi:10.3174/ajnr.A0746 pmid:17947371
    Abstract/FREE Full Text
  23. 23.↵
    1. Reeves C,
    2. Galang E,
    3. Padalia R, et al
    . Intrathecal injection of gadobutrol: a tale of caution. J Pain Palliat Care Pharmacother 2017;31:139–43 doi:10.1080/15360288.2017.1313353 pmid:28489466
    CrossRefPubMed
  24. 24.↵
    1. Kapoor R,
    2. Liu J,
    3. Devasenapathy A, et al
    . Gadolinium encephalopathy after intrathecal gadolinium injection. Pain Physician 2010;13:E321–26 pmid:20859323
    PubMed
  25. 25.↵
    1. Tali ET,
    2. Ercan N,
    3. Krumina G, et al
    . Intrathecal gadolinium (gadopentetate dimeglumine) enhanced magnetic resonance myelography and cisternography: results of a multicenter study. Invest Radiol 2002;37:152–59 doi:10.1097/00004424-200203000-00008 pmid:11882795
    CrossRefPubMedWeb of Science
  26. 26.↵
    1. Radbruch A,
    2. Weberling LD,
    3. Kieslich PJ, et al
    . Gadolinium retention in the dentate nucleus and globus pallidus is dependent on the class of contrast agent. Radiology 2015;275:783–91 doi:10.1148/radiol.2015150337 pmid:25848905
    CrossRefPubMed
  27. 27.↵
    1. Stojanov DA,
    2. Aracki-Trenkic A,
    3. Vojinovic S, et al
    . Increasing signal intensity within the dentate nucleus and globus pallidus on unenhanced T1W magnetic resonance images in patients with relapsing-remitting multiple sclerosis: correlation with cumulative dose of a macrocyclic gadolinium-based contrast age. Eur Radiol 2016;26:807–15 doi:10.1007/s00330-015-3879-9 pmid:26105022
    CrossRefPubMed
  28. 28.↵
    1. Kelemen P,
    2. Alaoui J,
    3. Sieron D, et al
    . T1-weighted grey matter signal intensity alterations after multiple administrations of gadobutrol in patients with multiple sclerosis, referenced to white matter. Sci Rep 2018;8:16844 doi:10.1038/s41598-018-35186-w pmid:30442977
    CrossRefPubMed
  29. 29.↵
    1. Öner AY,
    2. Barutcu B,
    3. Aykol Ş, et al
    . Intrathecal contrast-enhanced magnetic resonance imaging-related brain signal changes: residual gadolinium deposition? Invest Radiol 2017;52:195–97 doi:10.1097/RLI.0000000000000327 pmid:27755154
    CrossRefPubMed
  30. 30.↵
    1. Bakir B,
    2. Aydin K,
    3. Talu G, et al
    . Cranial magnetic resonance imaging in spontaneous intracranial hypotension after epidural blood patch. Pain Pract 2008;8:206–10 doi:10.1111/j.1533-2500.2008.00198.x pmid:18476898
    CrossRefPubMed
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 41 (7)
American Journal of Neuroradiology
Vol. 41, Issue 7
1 Jul 2020
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Spine MRI in Spontaneous Intracranial Hypotension for CSF Leak Detection: Nonsuperiority of Intrathecal Gadolinium to Heavily T2-Weighted Fat-Saturated Sequences
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
T. Dobrocky, A. Winklehner, P.S. Breiding, L. Grunder, G. Peschi, L. Häni, P.J. Mosimann, M. Branca, J. Kaesmacher, P. Mordasini, A. Raabe, C.T. Ulrich, J. Beck, J. Gralla, E.I. Piechowiak
Spine MRI in Spontaneous Intracranial Hypotension for CSF Leak Detection: Nonsuperiority of Intrathecal Gadolinium to Heavily T2-Weighted Fat-Saturated Sequences
American Journal of Neuroradiology Jul 2020, 41 (7) 1309-1315; DOI: 10.3174/ajnr.A6592

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Spine MRI in Spontaneous Intracranial Hypotension for CSF Leak Detection: Nonsuperiority of Intrathecal Gadolinium to Heavily T2-Weighted Fat-Saturated Sequences
T. Dobrocky, A. Winklehner, P.S. Breiding, L. Grunder, G. Peschi, L. Häni, P.J. Mosimann, M. Branca, J. Kaesmacher, P. Mordasini, A. Raabe, C.T. Ulrich, J. Beck, J. Gralla, E.I. Piechowiak
American Journal of Neuroradiology Jul 2020, 41 (7) 1309-1315; DOI: 10.3174/ajnr.A6592
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSIONS
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Mesoscale CISS Imaging for the Detection of Dural Defects in Spinal CSF Leaks
  • Spinal CSF Leaks: The Neuroradiologist Transforming Care
  • Modified Dynamic CT Myelography for Type 1 and 2 CSF Leaks: A Procedural Approach
  • Phase Contrast Spine MRI for the Evaluation of CSF Leak, and Why It Matters
  • Multiple Spinal CSF Leaks in Spontaneous Intracranial Hypotension: Do They Exist?
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Optimization of Photon Counting CT Myelography
  • Characteristics of SIH Type I Culprit Lesions
  • Management Outcomes For VO Spine Biopsy
Show more Spine Imaging and Spine Image-Guided Interventions

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire