Article Figures & Data
Figures
- Fig 1.
Glioma segmentation shown on axial FLAIR images of presurgical MR imaging (A) and postsurgical MR imaging (B) in a patient with a diffuse IDH-mutant astrocytoma who underwent subtotal resection.
- Fig 2.
Kaplan-Meier curves for overall patient survival based on the LGG molecular subtype. Vertical line segments along the curve identify right-censored survival times. IDHwt LGGs were associated with significantly worse overall survival compared with both IDH-mutant subtypes.
- Fig 3.
Kaplan-Meier curves in which overall patient survival is evaluated according to the percentage of glioma resection tertiles. Vertical line segments along the curve identify right-censored survival times. Data are shown for all patients with LGGs in the cohort (A) and separately for the 3 molecular subtypes (B–D).
Tables
IDHmut-Codel (n = 68) IDHmut-Noncodel (n = 63) IDHwt (n = 41) Sex Female 37 (54.4%) 30 (47.6%) 18 (43.9%) Male 31 (45.6%) 33 (52.4%) 23 (56.1%) Age (yr)a 45.5 (35.5–53) 33 (27–42.8) 57.0 (49.5–63.3) WHO grade II 50 (73.5%) 46 (73.0%) 25 (61.0%) III 18 (26.5%) 17 (27.0%) 16 (39.0%) Chemotherapy Yes 55 (80.9%) 53 (84.1%) 30 (73.2%) No 13 (19.1%) 10 (15.9%) 11 (26.8%) Radiation therapy Yes 45 (66.2%) 53 (84.1%) 31 (75.6%) No 23 (33.8%) 10 (15.9%) 10 (24.4%) Presurgical glioma volume (cm3)a 56.4 (26.5–111.6) 55.0 (31.0–116.2) 47.7 (18.0–86.4) Postsurgical glioma volume (cm3)a 28.4 (13.2–59.1) 29.3 (1.2–65.6) 30.1 (8.4–64.4) Mortality events 12 (17.6%) 14 (22.2%) 13 (31.7%) ↵a Data are listed as median and interquartile range. All other data are listed as absolute values and percentages.
Predictor Ratio Adjusted Hazard Ratio (95% CI) P Value All LGGs Presurgical glioma volume 3rd Q:1st Q 1.14 (0.79–1.64) .479 Postsurgical glioma volume 3rd Q:1st Q 1.80 (1.18–2.75) .006 Percentage glioma resection 25%:75% 3.22 (1.79–5.82) <.001 IDHmut-Codel Presurgical glioma volume 3rd Q:1st Q 1.11 (0.53–2.33) .781 Postsurgical glioma volume 3rd Q:1st Q 1.67 (0.82–3.48) .170 Percentage glioma resection 25%:75% 6.69 (1.57–28.46) .010 IDHmut-Noncodel Presurgical glioma volume 3rd Q:1st Q 3.20 (1.22–8.39) .018 Postsurgical glioma volume 3rd Q:1st Q 2.33 (1.32–4.12) .004 Percentage glioma resection 25%:75% 4.34 (1.74–10.81) .002 IDHwt Presurgical glioma volume 3rd Q:1st Q 2.18 (0.47–10.15) .319 Postsurgical glioma volume 3rd Q:1st Q 1.34 (0.28–4.76) .653 Percentage glioma resection 25%:75% 0.91 (0.29–2.82) .874 Note:—Q indicates quartile.
↵a Predictor variables for overall survival are presurgical glioma volume, postsurgical glioma volume, and percentage glioma resection. Adjusted hazard ratios are listed for the entire cohort and for the 3 molecular subtypes, with age, sex, glioma grade, and chemotherapy and radiation therapy administration as the adjustment variables.
