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Review ArticleAdult Brain
Open Access

Non-Contrast-Enhancing Tumor: A New Frontier in Glioblastoma Research

A. Lasocki and F. Gaillard
American Journal of Neuroradiology May 2019, 40 (5) 758-765; DOI: https://doi.org/10.3174/ajnr.A6025
A. Lasocki
aFrom the Department of Cancer Imaging (A.L.), Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
bSir Peter MacCallum Departments of Oncology (A.L.)
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F. Gaillard
cRadiology (F.G.), University of Melbourne, Parkville, Victoria, Australia
dDepartment of Radiology (F.G.), Royal Melbourne Hospital, Parkville, Victoria, Australia.
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REFERENCES

  1. 1.↵
    1. Louis DN,
    2. Ohgaki H,
    3. Wiestler OD, et al
    . World Health Organization Histological Classification of Tumors of the Central Nervous System. Lyon: International Agency for Research on Cancer; 2016
  2. 2.↵
    1. Yan H,
    2. Parsons DW,
    3. Jin G, et al
    . IDH1 and IDH2 mutations in gliomas. N Engl J Med 2009;360:765–73 doi:10.1056/NEJMoa0808710 pmid:19228619
    CrossRefPubMedWeb of Science
  3. 3.↵
    1. Weller M,
    2. van den Bent M,
    3. Tonn JC, et al
    ; European Association for Neuro-Oncology (EANO) Task Force on Gliomas. European Association for Neuro-Oncology (EANO) guideline on the diagnosis and treatment of adult astrocytic and oligodendroglial gliomas. Lancet Oncol 2017;18:e315–29 doi:10.1016/S1470-2045(17)30194-8 pmid:28483413
    CrossRefPubMed
  4. 4.↵
    1. Karachaliou N,
    2. Gonzalez-Cao M,
    3. Sosa A, et al
    . The combination of checkpoint immunotherapy and targeted therapy in cancer. Ann Transl Med 2017;5:388 doi:10.21037/atm.2017.06.47 pmid:29114546
    CrossRefPubMed
  5. 5.↵
    1. Lee YT,
    2. Tan YJ,
    3. Oon CE
    . Molecular targeted therapy: treating cancer with specificity. Eur J Pharmacol 2018;834:188–96 doi:10.1016/j.ejphar.2018.07.034 pmid:30031797
    CrossRefPubMed
  6. 6.↵
    1. Hardesty DA,
    2. Sanai N
    . The value of glioma extent of resection in the modern neurosurgical era. Front Neurol 2012;3:140 doi:10.3389/fneur.2012.00140 pmid:23087667
    CrossRefPubMed
  7. 7.↵
    1. Lacroix M,
    2. Abi-Said D,
    3. Fourney DR, et al
    . A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival. J Neurosurg 2001;95:190–98 doi:10.3171/jns.2001.95.2.0190 pmid:11780887
    CrossRefPubMedWeb of Science
  8. 8.↵
    1. Stummer W,
    2. Reulen HJ,
    3. Meinel T, et al
    ; ALA-Glioma Study Group. Extent of resection and survival in glioblastoma multiforme: identification of and adjustment for bias. Neurosurgery 2008;62:564–76; discussion 564–76 doi:10.1227/01.neu.0000317304.31579.17 pmid:18425006
    CrossRefPubMedWeb of Science
  9. 9.↵
    1. Chamberlain MC
    . Radiographic patterns of relapse in glioblastoma. J Neurooncol 2011;101:319–23 doi:10.1007/s11060-010-0251-4 pmid:21052776
    CrossRefPubMed
  10. 10.↵
    1. Kubben PL,
    2. ter Meulen KJ,
    3. Schijns OE, et al
    . Intraoperative MRI-guided resection of glioblastoma multiforme: a systematic review. Lancet Oncol 2011;12:1062–70 doi:10.1016/S1470-2045(11)70130-9 pmid:21868286
    CrossRefPubMedWeb of Science
  11. 11.↵
    1. Schulz C,
    2. Waldeck S,
    3. Mauer UM
    . Intraoperative image guidance in neurosurgery: development, current indications, and future trends. Radiol Res Pract 2012;2012:197364 doi:10.1155/2012/197364 pmid:22655196
    CrossRefPubMed
  12. 12.↵
    1. Zhao S,
    2. Wu J,
    3. Wang C, et al
    . Intraoperative fluorescence-guided resection of high-grade malignant gliomas using 5-aminolevulinic acid-induced porphyrins: a systematic review and meta-analysis of prospective studies. PLoS One 2013;8:e63682 doi:10.1371/journal.pone.0063682 pmid:23723993
    CrossRefPubMed
  13. 13.↵
    1. Lasocki A,
    2. Gaillard F,
    3. Tacey MA, et al
    . The incidence and significance of multicentric noncontrast-enhancing lesions distant from a histologically-proven glioblastoma. J Neurooncol 2016;129:471–78 doi:10.1007/s11060-016-2193-y pmid:27412000
    CrossRefPubMed
  14. 14.↵
    1. Eidel O,
    2. Burth S,
    3. Neumann JO, et al
    . Tumor infiltration in enhancing and non-enhancing parts of glioblastoma: a correlation with histopathology. PLoS One 2017;12:e0169292 doi:10.1371/journal.pone.0169292 pmid:28103256
    CrossRefPubMed
  15. 15.↵
    1. Jain R,
    2. Poisson LM,
    3. Gutman D, et al
    . Outcome prediction in patients with glioblastoma by using imaging, clinical, and genomic biomarkers: focus on the nonenhancing component of the tumor. Radiology 2014;272:484–93 doi:10.1148/radiol.14131691 pmid:24646147
    CrossRefPubMed
  16. 16.↵
    1. Lasocki A,
    2. Gaillard F,
    3. Tacey M, et al
    . Incidence and prognostic significance of non-enhancing cortical signal abnormality in glioblastoma. J Med Imaging Radiat Oncol 2016;60:66–73 doi:10.1111/1754-9485.12421 pmid:26597591
    CrossRefPubMed
  17. 17.↵
    1. Grabowski MM,
    2. Recinos PF,
    3. Nowacki AS, et al
    . Residual tumor volume versus extent of resection: predictors of survival after surgery for glioblastoma. J Neurosurg 2014;121:1115–23 doi:10.3171/2014.7.JNS132449 pmid:25192475
    CrossRefPubMedWeb of Science
  18. 18.↵
    1. Kotrotsou A,
    2. Elakkad A,
    3. Sun J, et al
    . Multi-center study finds postoperative residual non-enhancing component of glioblastoma as a new determinant of patient outcome. J Neurooncol 2018;139:125–33 doi:10.1007/s11060-018-2850-4 pmid:29619649
    CrossRefPubMed
  19. 19.↵
    1. Carrillo JA,
    2. Lai A,
    3. Nghiemphu PL, et al
    . Relationship between tumor enhancement, edema, IDH1 mutational status, MGMT promoter methylation, and survival in glioblastoma. AJNR Am J Neuroradiol 2012;33:1349–55 doi:10.3174/ajnr.A2950 pmid:22322613
    Abstract/FREE Full Text
  20. 20.↵
    1. Lasocki A,
    2. Tsui A,
    3. Gaillard F, et al
    . Reliability of noncontrast-enhancing tumor as a biomarker of IDH1 mutation status in glioblastoma. J Clin Neurosci 2017;39:170–75 doi:10.1016/j.jocn.2017.01.007 pmid:28214089
    CrossRefPubMed
  21. 21.↵
    1. Hygino da Cruz LC Jr.,
    2. Rodriguez I,
    3. Domingues RC, et al
    . Pseudoprogression and pseudoresponse: imaging challenges in the assessment of posttreatment glioma. AJNR Am J Neuroradiol 2011;32:1978–85 doi:10.3174/ajnr.A2397 pmid:21393407
    Abstract/FREE Full Text
  22. 22.↵
    1. Wen PY,
    2. Macdonald DR,
    3. Reardon DA, et al
    . Updated response assessment criteria for high-grade gliomas: Response Assessment in Neuro-Oncology Working Group. J Clin Oncol 2010;28:1963–72 doi:10.1200/JCO.2009.26.3541 pmid:20231676
    Abstract/FREE Full Text
  23. 23.↵
    1. Boxerman JL,
    2. Zhang Z,
    3. Safriel Y, et al
    . Prognostic value of contrast enhancement and FLAIR for survival in newly diagnosed glioblastoma treated with and without bevacizumab: results from ACRIN 6686. Neuro Oncol 2018;20:1400–10 doi:10.1093/neuonc/noy049 pmid:29590461
    CrossRefPubMed
  24. 24.↵
    1. Huang RY,
    2. Rahman R,
    3. Ballman KV, et al
    . The impact of T2/FLAIR evaluation per RANO criteria on response assessment of recurrent glioblastoma patients treated with bevacizumab. Clin Cancer Res 2016;22:575–81 doi:10.1158/1078-0432.CCR-14-3040 pmid:26490307
    Abstract/FREE Full Text
  25. 25.↵
    1. Nowosielski M,
    2. Wiestler B,
    3. Goebel G, et al
    . Progression types after antiangiogenic therapy are related to outcome in recurrent glioblastoma. Neurology 2014;82:1684–92 doi:10.1212/WNL.0000000000000402 pmid:24727314
    CrossRefPubMed
  26. 26.↵
    1. Yordanova YN,
    2. Moritz-Gasser S,
    3. Duffau H
    . Awake surgery for WHO grade II gliomas within “noneloquent” areas in the left dominant hemisphere: toward a “supratotal” resection: clinical article. J Neurosurg 2011;115:232–39 doi:10.3171/2011.3.JNS101333 pmid:21548750
    CrossRefPubMedWeb of Science
  27. 27.↵
    1. Li YM,
    2. Suki D,
    3. Hess K, et al
    . The influence of maximum safe resection of glioblastoma on survival in 1229 patients: can we do better than gross-total resection? J Neurosurg 2016;124:977–88 doi:10.3171/2015.5.JNS142087 pmid:26495941
    CrossRefPubMed
  28. 28.↵
    1. Pessina F,
    2. Navarria P,
    3. Cozzi L, et al
    . Maximize surgical resection beyond contrast-enhancing boundaries in newly diagnosed glioblastoma multiforme: is it useful and safe? A single institution retrospective experience. J Neurooncol 2017;135:129–39 doi:10.1007/s11060-017-2559-9 pmid:28689368
    CrossRefPubMed
  29. 29.↵
    1. Beiko J,
    2. Suki D,
    3. Hess KR, et al
    . IDH1 mutant malignant astrocytomas are more amenable to surgical resection and have a survival benefit associated with maximal surgical resection. Neuro Oncol 2014;16:81–91 doi:10.1093/neuonc/not159 pmid:24305719
    CrossRefPubMed
  30. 30.↵
    1. Pope WB,
    2. Sayre J,
    3. Perlina A, et al
    . MR imaging correlates of survival in patients with high-grade gliomas. AJNR Am J Neuroradiol 2005;26:2466–74 pmid:16286386
    Abstract/FREE Full Text
  31. 31.↵
    1. Lasocki A,
    2. Gaillard F,
    3. Tacey M, et al
    . Morphologic patterns of noncontrast-enhancing tumor in glioblastoma correlate with IDH1 mutation status and patient survival. J Clin Neurosci 2018;47:168–73 doi:10.1016/j.jocn.2017.09.007 pmid:28988652
    CrossRefPubMed
  32. 32.↵
    1. Baldock AL,
    2. Ahn S,
    3. Rockne R, et al
    . Patient-specific metrics of invasiveness reveal significant prognostic benefit of resection in a predictable subset of gliomas. PLoS One 2014;9:e99057 doi:10.1371/journal.pone.0099057 pmid:25350742
    CrossRefPubMed
  33. 33.↵
    1. Stupp R,
    2. Mason WP,
    3. van den Bent MJ, et al
    ; European Organisation for Research and Treatment of Cancer Brain Tumor and Radiotherapy Groups, National Cancer Institute of Canada Clinical Trials Group. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005;352:987–96 doi:10.1056/NEJMoa043330 pmid:15758009
    CrossRefPubMedWeb of Science
  34. 34.↵
    1. Duma CM,
    2. Kim BS,
    3. Chen PV, et al
    . Upfront boost gamma knife “leading-edge” radiosurgery to FLAIR MRI-defined tumor migration pathways in 174 patients with glioblastoma multiforme: a 15-year assessment of a novel therapy. J Neurosurg 2016;125(Suppl 1):40–49 doi:10.3171/2016.7.GKS161460 pmid:27903197
    CrossRefPubMed
  35. 35.↵
    Wiki for the VASARI feature set. The National Cancer Institute. 2015. https://wiki.cancerimagingarchive.net/display/Public/VASARI+Research+Project. Accessed November 22, 2018.
  36. 36.↵
    1. Muccio CF,
    2. Tarantino A,
    3. Esposito G, et al
    . Differential diagnosis by unenhanced FLAIR T2-weighted magnetic resonance images between solitary high grade gliomas and cerebral metastases appearing as contrast-enhancing cortico-subcortical lesions. J Neurooncol 2011;103:713–17 doi:10.1007/s11060-010-0454-8 pmid:21069426
    CrossRefPubMed
  37. 37.↵
    1. Stuckey SL,
    2. Wijedeera R
    . Multicentric/multifocal cerebral lesions: can fluid-attenuated inversion recovery aid the differentiation between glioma and metastases? J Med Imaging Radiat Oncol 2008;52:134–39 doi:10.1111/j.1440-1673.2008.01931.x pmid:18373804
    CrossRefPubMed
  38. 38.↵
    1. Tang YM,
    2. Ngai S,
    3. Stuckey S
    . The solitary enhancing cerebral lesion: can FLAIR aid the differentiation between glioma and metastasis? AJNR Am J Neuroradiol 2006;27:609–11 pmid:16552003
    Abstract/FREE Full Text
  39. 39.↵
    1. Chang PD,
    2. Malone HR,
    3. Bowden SG, et al
    . A multiparametric model for mapping cellularity in glioblastoma using radiographically localized biopsies. AJNR Am J Neuroradiol 2017;38:890–98 doi:10.3174/ajnr.A5112 pmid:28255030
    Abstract/FREE Full Text
  40. 40.↵
    1. Lasocki A,
    2. Gaillard F,
    3. Tacey M, et al
    . Multifocal and multicentric glioblastoma: improved characterisation with FLAIR imaging and prognostic implications. J Clin Neurosci 2016;31:92–98 doi:10.1016/j.jocn.2016.02.022 pmid:27343042
    CrossRefPubMed
  41. 41.↵
    1. Brandão LA,
    2. Shiroishi MS,
    3. Law M
    . Brain tumors: a multimodality approach with diffusion-weighted imaging, diffusion tensor imaging, magnetic resonance spectroscopy, dynamic susceptibility contrast and dynamic contrast-enhanced magnetic resonance imaging. Magn Reson Imaging Clin N Am 2013;21:199–239 doi:10.1016/j.mric.2013.02.003 pmid:23642551
    CrossRefPubMed
  42. 42.↵
    1. Guo AC,
    2. Cummings TJ,
    3. Dash RC, et al
    . Lymphomas and high-grade astrocytomas: comparison of water diffusibility and histologic characteristics. Radiology 2002;224:177–83 doi:10.1148/radiol.2241010637 pmid:12091680
    CrossRefPubMedWeb of Science
  43. 43.↵
    1. Kono K,
    2. Inoue Y,
    3. Nakayama K, et al
    . The role of diffusion-weighted imaging in patients with brain tumors. AJNR Am J Neuroradiol 2001;22:1081–88 pmid:11415902
    Abstract/FREE Full Text
  44. 44.↵
    1. Tien RD,
    2. Felsberg GJ,
    3. Friedman H, et al
    . MR imaging of high-grade cerebral gliomas: value of diffusion-weighted echoplanar pulse sequences. AJR Am J Roentgenol 1994;162:671–77 doi:10.2214/ajr.162.3.8109520 pmid:8109520
    CrossRefPubMedWeb of Science
  45. 45.↵
    1. Castillo M,
    2. Smith JK,
    3. Kwock L, et al
    . Apparent diffusion coefficients in the evaluation of high-grade cerebral gliomas. AJNR Am J Neuroradiol 2001;22:60–64 pmid:11158889
    Abstract/FREE Full Text
  46. 46.↵
    1. Holodny AI,
    2. Makeyev S,
    3. Beattie BJ, et al
    . Apparent diffusion coefficient of glial neoplasms: correlation with fluorodeoxyglucose-positron-emission tomography and gadolinium-enhanced MR imaging. AJNR Am J Neuroradiol 2010;31:1042–48 doi:10.3174/ajnr.A1989 pmid:20150307
    Abstract/FREE Full Text
  47. 47.↵
    1. Price SJ,
    2. Jena R,
    3. Burnet NG, et al
    . Improved delineation of glioma margins and regions of infiltration with the use of diffusion tensor imaging: an image-guided biopsy study. AJNR Am J Neuroradiol 2006;27:1969–74 pmid:17032877
    Abstract/FREE Full Text
  48. 48.↵
    1. Stadlbauer A,
    2. Ganslandt O,
    3. Buslei R, et al
    . Gliomas: histopathologic evaluation of changes in directionality and magnitude of water diffusion at diffusion-tensor MR imaging. Radiology 2006;240:803–10 doi:10.1148/radiol.2403050937 pmid:16926329
    CrossRefPubMedWeb of Science
  49. 49.↵
    1. Ellingson BM,
    2. Malkin MG,
    3. Rand SD, et al
    . Validation of functional diffusion maps (fDMs) as a biomarker for human glioma cellularity. J Magn Reson Imaging 2010;31:538–48 doi:10.1002/jmri.22068 pmid:20187195
    CrossRefPubMedWeb of Science
  50. 50.↵
    1. Zeng Q,
    2. Ling C,
    3. Shi F, et al
    . Glioma infiltration sign on high b-value diffusion-weighted imaging in gliomas and its prognostic value. J Magn Reson Imaging 2018 Mar 1. [Epub ahead of print] doi:10.1002/jmri.25986 pmid:29498144
    CrossRefPubMed
  51. 51.↵
    1. Price SJ,
    2. Green HA,
    3. Dean AF, et al
    . Correlation of MR relative cerebral blood volume measurements with cellular density and proliferation in high-grade gliomas: an image-guided biopsy study. AJNR Am J Neuroradiol 2011;32:501–06 doi:10.3174/ajnr.A2312 pmid:21163880
    Abstract/FREE Full Text
  52. 52.↵
    1. Sadeghi N,
    2. D'Haene N,
    3. Decaestecker C, et al
    . Apparent diffusion coefficient and cerebral blood volume in brain gliomas: relation to tumor cell density and tumor microvessel density based on stereotactic biopsies. AJNR Am J Neuroradiol 2008;29:476–82 doi:10.3174/ajnr.A0851 pmid:18079184
    Abstract/FREE Full Text
  53. 53.↵
    1. Gupta A,
    2. Young RJ,
    3. Karimi S, et al
    . Isolated diffusion restriction precedes the development of enhancing tumor in a subset of patients with glioblastoma. AJNR Am J Neuroradiol 2011;32:1301–06 doi:10.3174/ajnr.A2479 pmid:21596805
    Abstract/FREE Full Text
  54. 54.↵
    1. Danchaivijitr N,
    2. Waldman AD,
    3. Tozer DJ, et al
    . Low-grade gliomas: do changes in rCBV measurements at longitudinal perfusion-weighted MR imaging predict malignant transformation? Radiology 2008;247:170–78 doi:10.1148/radiol.2471062089 pmid:18372467
    CrossRefPubMed
  55. 55.↵
    1. Stadlbauer A,
    2. Gruber S,
    3. Nimsky C, et al
    . Preoperative grading of gliomas by using metabolite quantification with high-spatial-resolution proton MR spectroscopic imaging. Radiology 2006;238:958–69 doi:10.1148/radiol.2382041896 pmid:16424238
    CrossRefPubMedWeb of Science
  56. 56.↵
    1. Castillo M,
    2. Smith JK,
    3. Kwock L
    . Correlation of myo-inositol levels and grading of cerebral astrocytomas. AJNR Am J Neuroradiol 2000;21:1645–49 pmid:11039343
    Abstract/FREE Full Text
  57. 57.↵
    1. Nowosielski M,
    2. DiFranco MD,
    3. Putzer D, et al
    . An intra-individual comparison of MRI, [18F]-FET and [18F]-FLT PET in patients with high-grade gliomas. PLoS One 2014;9:e95830 doi:10.1371/journal.pone.0095830 pmid:24759867
    CrossRefPubMed
  58. 58.↵
    1. Lopez WO,
    2. Cordeiro JG,
    3. Albicker U, et al
    . Correlation of (18)F-fluoroethyl tyrosine positron-emission tomography uptake values and histomorphological findings by stereotactic serial biopsy in newly diagnosed brain tumors using a refined software tool. Onco Targets Ther 2015;8:3803–15 doi:10.2147/OTT.S87126 pmid:26719708
    CrossRefPubMed
  59. 59.↵
    1. Artzi M,
    2. Liberman G,
    3. Blumenthal DT, et al
    . Differentiation between vasogenic edema and infiltrative tumor in patients with high-grade gliomas using texture patch-based analysis. J Magn Reson Imaging 2018 Jan 3. [Epub ahead of print] doi:10.1002/jmri.25939 pmid:29314345
    CrossRefPubMed
  60. 60.↵
    1. Hu LS,
    2. Ning S,
    3. Eschbacher JM, et al
    . Multi-parametric MRI and texture analysis to visualize spatial histologic heterogeneity and tumor extent in glioblastoma. PLoS One 2015;10:e0141506 doi:10.1371/journal.pone.0141506 pmid:26599106
    CrossRefPubMed
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American Journal of Neuroradiology: 40 (5)
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A. Lasocki, F. Gaillard
Non-Contrast-Enhancing Tumor: A New Frontier in Glioblastoma Research
American Journal of Neuroradiology May 2019, 40 (5) 758-765; DOI: 10.3174/ajnr.A6025

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Non-Contrast-Enhancing Tumor: A New Frontier in Glioblastoma Research
A. Lasocki, F. Gaillard
American Journal of Neuroradiology May 2019, 40 (5) 758-765; DOI: 10.3174/ajnr.A6025
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