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Review ArticleAdult Brain
Open Access

Non-Contrast-Enhancing Tumor: A New Frontier in Glioblastoma Research

A. Lasocki and F. Gaillard
American Journal of Neuroradiology May 2019, 40 (5) 758-765; DOI: https://doi.org/10.3174/ajnr.A6025
A. Lasocki
aFrom the Department of Cancer Imaging (A.L.), Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
bSir Peter MacCallum Departments of Oncology (A.L.)
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F. Gaillard
cRadiology (F.G.), University of Melbourne, Parkville, Victoria, Australia
dDepartment of Radiology (F.G.), Royal Melbourne Hospital, Parkville, Victoria, Australia.
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    Fig 1.

    FLAIR imaging (A) showing edema around the CET component (B) sparing the cortex (arrowhead), producing the characteristic fingerlike appearance.

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    Fig 2.

    FLAIR imaging (A) showing edema extending around the left lentiform nucleus. The CET component is shown in B.

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    Fig 3.

    FLAIR imaging (A) demonstrating nCET involving the anterior right temporal cortex (asterisk), insula, and thalamus (arrowhead). A narrow window width has been used to improve conspicuity. The small CET component lies further superiorly (B, arrow).

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    Fig 4.

    FLAIR imaging (A) showing eccentric extension of nCET across the corpus callosum, with associated expansion (arrowhead). Rounded hyperintensity in the left thalamus (arrow) is also consistent with nCET. Note the paucity of edema in the white matter immediately adjacent to the CET component (B).

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  • Conventional and advanced MRI features useful for differentiating between nCET and edema

    nCETEdema
    Conventional MRI features
        Gray matter involvementSpares the gray matter
        EccentricRelatively concentric around enhancing lesions
        Relatively mild FLAIR and T2 hyperintensityMore marked FLAIR and T2 hyperintensity
        Focal parenchymal expansionMore diffuse mass effect if marked edema
    Advanced MRI sequences
        Relative diffusion restrictionFacilitated diffusion
        Choline elevation, NAA depletionNormal MRS findings
        Elevated rCBV around CETrCBV elevation confined to CET
    • Note:—rCBV indicates relative cerebral blood volume.

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American Journal of Neuroradiology: 40 (5)
American Journal of Neuroradiology
Vol. 40, Issue 5
1 May 2019
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Cite this article
A. Lasocki, F. Gaillard
Non-Contrast-Enhancing Tumor: A New Frontier in Glioblastoma Research
American Journal of Neuroradiology May 2019, 40 (5) 758-765; DOI: 10.3174/ajnr.A6025

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Non-Contrast-Enhancing Tumor: A New Frontier in Glioblastoma Research
A. Lasocki, F. Gaillard
American Journal of Neuroradiology May 2019, 40 (5) 758-765; DOI: 10.3174/ajnr.A6025
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