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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleNeurointervention
Open Access

Metallic Hyperdensity Sign on Noncontrast CT Immediately after Mechanical Thrombectomy Predicts Parenchymal Hemorrhage in Patients with Acute Large-Artery Occlusion

C. Xu, Y. Zhou, R. Zhang, Z. Chen, W. Zhong, X. Gong, X. Ding and M. Lou
American Journal of Neuroradiology April 2019, 40 (4) 661-667; DOI: https://doi.org/10.3174/ajnr.A6008
C. Xu
aFrom the Departments of Neurology (C.X., Y.Z., R.Z., Z.C., W.Z, X.G., M.L.)
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Y. Zhou
aFrom the Departments of Neurology (C.X., Y.Z., R.Z., Z.C., W.Z, X.G., M.L.)
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R. Zhang
aFrom the Departments of Neurology (C.X., Y.Z., R.Z., Z.C., W.Z, X.G., M.L.)
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Z. Chen
aFrom the Departments of Neurology (C.X., Y.Z., R.Z., Z.C., W.Z, X.G., M.L.)
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W. Zhong
aFrom the Departments of Neurology (C.X., Y.Z., R.Z., Z.C., W.Z, X.G., M.L.)
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X. Gong
aFrom the Departments of Neurology (C.X., Y.Z., R.Z., Z.C., W.Z, X.G., M.L.)
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X. Ding
bRadiology (X.D.), the Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.
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M. Lou
aFrom the Departments of Neurology (C.X., Y.Z., R.Z., Z.C., W.Z, X.G., M.L.)
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  • Fig 1.
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    Fig 1.

    Three patients with 3 kinds of metallic hyperdensity signs. A, C, and E, NCCT images obtained immediately after mechanical thrombectomy. B and D, SWI at 24 hours after mechanical thrombectomy. F, NCCT image at 24 hours after mechanical thrombectomy. A 77-year-old woman with a hyperdense lesion and a maximum CT density of 121 HU in the right caudate nucleus on NCCT images immediately after mechanical thrombectomy (A) has parenchymal hemorrhage on SWI at 24 hours (B). A 71-year-old man with a hyperdense lesion and a maximum CT density of 93 HU in the left lenticular nucleus on NCCT images immediately after mechanical thrombectomy (C) has parenchymal hemorrhage on SWI at 24 hours (D). An 81-year-old man with a hyperdense lesion and a maximum CT density of 164 HU in the left lenticular nucleus on NCCT images immediately after mechanical thrombectomy (E) has parenchymal hemorrhage on the NCCT image at 24 hours (F).

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    Fig 2.

    Two patients who show the typical cortical hyperdense lesion on NCCT immediately after MT (A and C) have no HT on follow-up SWI (B and D).

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    Fig 3.

    Two patients who show a petechial hyperdense lesion in the basal ganglia on NCCT immediately after MT (A and C) have no HT on follow-up SWI (B) and the remaining low densities on follow-up NCCT (D).

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    Fig 4.

    A patient who shows a nonpetechial hyperdense lesion on NCCT immediately after MT (A) has no HT on follow-up NCCT and the remaining low densities (B).

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    Fig 5.

    A patient who shows the subcortical hyperdense lesion involving both the basal ganglia and subcortical white matter on NCCT immediately after MT (A) has no HT on NCCT immediately after MT and the remaining low densities on follow-up NCCT (B).

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    Fig 6.

    A patient who shows the subcortical hyperdense lesion on NCCT immediately after MT (A) but has no HT on follow-up NCCT and the remaining low densities (B).

Tables

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    Table 1:

    Predictive value of characteristics of metallic hyperdensity for parenchymal hemorrhage

    AUC95% CIP ValueSensitivitySpecificityPositive Predictive ValueNegative Predictive Value
    Presence of metallic hyperdensity sign0.8940.835–0.952<.0010.8820.9050.7630.957
    • Note:—AUC indicates area under the curve.

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    Table 2:

    Comparison of characteristics between patients with and without the metallic hyperdensity sign

    CharacteristicsPresence of Metallic Hyperdensity Sign (n = 59)Absence of Metallic Hyperdensity Sign (n = 139)P Value
    Age (mean) (yr)70.5 ± 10.569.4 ± 12.2.568
    Female (No.) (%)26 (44.1)56 (40.3).639
    Comorbid conditions
        Hypertension (No.) (%)37 (62.7)84 (60.4).874
        Diabetes mellitus (No.) (%)14 (23.7)24 (17.3).326
        Atrial fibrillation (No.) (%)35 (59.3)50 (35.9).003
    Clinical variables
        Baseline NIHSS (median) (IQR)15 (12–18)14 (10–17).116
        Onset-to-puncture time (median) (IQR) (min)334 (237–425)306 (213–415).289
        Retrieval attempts (median) (IQR)2 (1–3)1 (1–3).039
    Radiologic data
        Baseline infarct volume (median) (IQR) (mL)59.9 (34.7–80.9)46.3 (27.5–80.0).096
        Baseline hypoperfusion volume (median) (IQR) (mL)108.9 (79.2–153.6)107.1 (68.0–160.0).639
        Recanalization (No.) (%)48 (81.4)123 (88.4).181
        24-Hour hemorrhagic transformation (No.) (%)58 (98.3)54 (38.8)<.001
        24-Hour parenchymal hemorrhage (No.) (%)45 (76.3)6 (4.3)<.001
    • Note:—IQR indicates interquartile range.

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American Journal of Neuroradiology: 40 (4)
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C. Xu, Y. Zhou, R. Zhang, Z. Chen, W. Zhong, X. Gong, X. Ding, M. Lou
Metallic Hyperdensity Sign on Noncontrast CT Immediately after Mechanical Thrombectomy Predicts Parenchymal Hemorrhage in Patients with Acute Large-Artery Occlusion
American Journal of Neuroradiology Apr 2019, 40 (4) 661-667; DOI: 10.3174/ajnr.A6008

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Metallic Hyperdensity Sign on Noncontrast CT Immediately after Mechanical Thrombectomy Predicts Parenchymal Hemorrhage in Patients with Acute Large-Artery Occlusion
C. Xu, Y. Zhou, R. Zhang, Z. Chen, W. Zhong, X. Gong, X. Ding, M. Lou
American Journal of Neuroradiology Apr 2019, 40 (4) 661-667; DOI: 10.3174/ajnr.A6008
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Cited By...

  • Combinations of Clinical Factors, CT Signs, and Radiomics for Differentiating High-Density Areas after Mechanical Thrombectomy in Patients with Acute Ischemic Stroke
  • Incidence, Risk Factors, and Clinical Implications of Subarachnoid Hyperdensities on Flat-Panel Detector CT following Mechanical Thrombectomy in Patients with Anterior Circulation Acute Ischemic Stroke
  • Contrast extravasation and outcome of endovascular therapy in acute ischaemic stroke: a systematic review and meta-analysis
  • Association of maximal systolic blood pressure with poor outcome in patients with hyperattenuated lesions on immediate NCCT after mechanical thrombectomy
  • Prediction of Hemorrhage after Successful Recanalization in Patients with Acute Ischemic Stroke: Improved Risk Stratification Using Dual-Energy CT Parenchymal Iodine Concentration Ratio Relative to the Superior Sagittal Sinus
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