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Research ArticleAdult Brain
Open Access

Moving Toward a Consensus DSC-MRI Protocol: Validation of a Low–Flip Angle Single-Dose Option as a Reference Standard for Brain Tumors

K.M. Schmainda, M.A. Prah, L.S. Hu, C.C. Quarles, N. Semmineh, S.D. Rand, J.M. Connelly, B. Anderies, Y. Zhou, Y. Liu, B. Logan, A. Stokes, G. Baird and J.L. Boxerman
American Journal of Neuroradiology April 2019, 40 (4) 626-633; DOI: https://doi.org/10.3174/ajnr.A6015
K.M. Schmainda
aFrom the Departments of Biophysics (K.M.S., M.A.P.)
bRadiology (K.M.S., S.D.R.)
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M.A. Prah
aFrom the Departments of Biophysics (K.M.S., M.A.P.)
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L.S. Hu
eDepartments of Radiology (L.S.H., Y.Z.)
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C.C. Quarles
gDivision of Imaging Research (C.C.Q., N.S., A.S.), Barrow Neurological Institute, Phoenix, Arizona
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N. Semmineh
gDivision of Imaging Research (C.C.Q., N.S., A.S.), Barrow Neurological Institute, Phoenix, Arizona
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S.D. Rand
bRadiology (K.M.S., S.D.R.)
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J.M. Connelly
cNeurology (J.M.C.)
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B. Anderies
fNeurosurgery (B.A.), Mayo Clinic, Scottsdale, Arizona
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Y. Zhou
eDepartments of Radiology (L.S.H., Y.Z.)
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Y. Liu
dDivision of Biostatistics, Institute for Health and Society (Y.L., B.L.), Medical College of Wisconsin, Milwaukee, Wisconsin
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B. Logan
dDivision of Biostatistics, Institute for Health and Society (Y.L., B.L.), Medical College of Wisconsin, Milwaukee, Wisconsin
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A. Stokes
gDivision of Imaging Research (C.C.Q., N.S., A.S.), Barrow Neurological Institute, Phoenix, Arizona
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G. Baird
hDepartment of Diagnostic Imaging (J.L.B., G.B.), Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, Rhode Island.
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J.L. Boxerman
hDepartment of Diagnostic Imaging (J.L.B., G.B.), Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, Rhode Island.
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American Journal of Neuroradiology: 40 (4)
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K.M. Schmainda, M.A. Prah, L.S. Hu, C.C. Quarles, N. Semmineh, S.D. Rand, J.M. Connelly, B. Anderies, Y. Zhou, Y. Liu, B. Logan, A. Stokes, G. Baird, J.L. Boxerman
Moving Toward a Consensus DSC-MRI Protocol: Validation of a Low–Flip Angle Single-Dose Option as a Reference Standard for Brain Tumors
American Journal of Neuroradiology Apr 2019, 40 (4) 626-633; DOI: 10.3174/ajnr.A6015

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Moving Toward a Consensus DSC-MRI Protocol: Validation of a Low–Flip Angle Single-Dose Option as a Reference Standard for Brain Tumors
K.M. Schmainda, M.A. Prah, L.S. Hu, C.C. Quarles, N. Semmineh, S.D. Rand, J.M. Connelly, B. Anderies, Y. Zhou, Y. Liu, B. Logan, A. Stokes, G. Baird, J.L. Boxerman
American Journal of Neuroradiology Apr 2019, 40 (4) 626-633; DOI: 10.3174/ajnr.A6015
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  • Multisite Benchmark Study for Standardized Relative CBV in Untreated Brain Metastases Using the DSC-MRI Consensus Acquisition Protocol
  • "Synthetic" DSC Perfusion MRI with Adjustable Acquisition Parameters in Brain Tumors Using Dynamic Spin-and-Gradient-Echo Echoplanar Imaging
  • Identification of a Single-Dose, Low-Flip-Angle-Based CBV Threshold for Fractional Tumor Burden Mapping in Recurrent Glioblastoma
  • Arterial Spin-Labeling and DSC Perfusion Metrics Improve Agreement in Neuroradiologists Clinical Interpretations of Posttreatment High-Grade Glioma Surveillance MR Imaging--An Institutional Experience
  • The Choroid Plexus as an Alternative Locus for the Identification of the Arterial Input Function for Calculating Cerebral Perfusion Metrics Using MRI
  • DSC Perfusion MRI-Derived Fractional Tumor Burden and Relative CBV Differentiate Tumor Progression and Radiation Necrosis in Brain Metastases Treated with Stereotactic Radiosurgery
  • Performance of Standardized Relative CBV for Quantifying Regional Histologic Tumor Burden in Recurrent High-Grade Glioma: Comparison against Normalized Relative CBV Using Image-Localized Stereotactic Biopsies
  • Perfusion MRI-Based Fractional Tumor Burden Differentiates between Tumor and Treatment Effect in Recurrent Glioblastomas and Informs Clinical Decision-Making
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