Improved Spatiotemporal Resolution of Dynamic Susceptibility Contrast Perfusion MRI in Brain Tumors Using Simultaneous Multi-Slice Echo-Planar Imaging

Postcontrast T1-weighted images, T2-weighted FLAIR images, and raw T2*-weighted DSC MR images with corresponding signal-time curves across time from tumor regions accompanied by resulting relative cerebral blood volume maps for conventional single-shot EPI (A) and simultaneous multi-slice EPI (B) (left to right). Percentage difference in mean tumor rCBV ratio (tumor to normal-appearing white matter) (C) and percentage difference in the maximum tumor rCBV ratio (tumor to normal-appearing white matter) (D) in 13 patients with recurrent glioblastoma. E, Voxelwise correlation of rCBV ratio between conventional single-shot EPI and SMS-EPI.