Gadolinium DTPA Enhancement Characteristics of the Rat Sciatic Nerve after Crush Injury at 4.7T

HTML Page - index.htslp

Files in this Data Supplement:

• Online Video 1 - DCE axial T1WI with fat saturation, pre- (frame 1) and post- (frames 2-12) Gd-DTPA. Each frame represents approximately 13 minutes. Gd-DTPA wash-in and wash-out are observed proximal to, in the region of, and distal to the site of crush injury. Distal to the site of injury, the peripheral portion of the injured nerve enhances first (frame 2), followed by the central portion (frame 3). Proximal to the site of injury, enhancement is seen migrating proximally long after contrast injection (frames 2-7).
• Online Video 2 - DCE axial T1WI with fat saturation, pre- (frame 1) and post- (frames 2-12) Gd-DTPA. Each frame represents approximately 13 minutes. The nonoperative contralateral nerve is well seen in this slice and demonstrates a thin rim of peripheral enhancement but no internal enhancement.
• Online Video 3 - DCE axial T1WI with fat saturation, pre- (frame 1) and post- (frames 2-12) Gd-DTPA. Each frame represents approximately 13 minutes. Enhancement is seen in a distal branch of the injured sciatic nerve.
• Online Video 4 - DCE axial T1WI with fat saturation, pre- (frame 1) and post- (frames 2-25) Gd-DTPA. Each frame represents approximately 47 seconds. Injured nerve enhancement reaches a plateau approximately 10 minutes after the intravenous administration of Gd-DTPA. The presence of a delayed, higher peak compared to nonoperative nerve suggests an enlarged extravascular extracellular space (ve) after severe (forceps) crush injury.¹³