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Research ArticlePEDIATRICS

Does 3T Fetal MRI Improve Image Resolution of Normal Brain Structures between 20 and 24 Weeks' Gestational Age?

G. Priego, N.J. Barrowman, J. Hurteau-Miller and E. Miller
American Journal of Neuroradiology August 2017, 38 (8) 1636-1642; DOI: https://doi.org/10.3174/ajnr.A5251
G. Priego
aFrom the Department of Medical Imaging (G.P., J.H.-M., E.M.)
cDr Priego is now with Department of Medical Imaging, Queen's Hospital, London, UK.
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N.J. Barrowman
bResearch Institute (N.J.B.), Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada.
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J. Hurteau-Miller
aFrom the Department of Medical Imaging (G.P., J.H.-M., E.M.)
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E. Miller
aFrom the Department of Medical Imaging (G.P., J.H.-M., E.M.)
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  • Fig 1.
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    Fig 1.

    Sagittal T2 midline images of fetuses. Examples provide the qualitative assessment of the primary fissure of the cerebellum (arrows). A, Gestational age (GA), 21 weeks 1 day; 1.5T; score 0: no visible structure. B, GA, 21 weeks; 1.5T; score 1: partially visible structure. C, GA, 22 weeks; 1.5T; score 2: entirely visible structure, but ill-defined contour. D, GA, 20 weeks; 3T; score 3: entirely visible and sharp margins.

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    Fig 2.

    A coronal image was selected from each scan at the level of the third ventricle. One-millimeter ROIs were drawn in the developing brain layers: 1) germinal matrix, 2) periventricular, 3) subplate, and 4) cortical plate. These values were compared with an ROI outside the patient (air). This fetus had a GA of 20 weeks, scanned at 3T.

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    Fig 3.

    Estimated differences in the mean score between magnet types at each location from a linear mixed-effects model. Estimates are accompanied by 95% confidence intervals, adjusted for multiple testing.

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    Fig 4.

    The ratio between signal intensity and air at each location for each magnet. Each estimated ratio is shown as a small circle. Each superimposed box indicates the 25th percentile (lower part of the box), median (heavy horizontal line), and 75th percentile (upper part of the box). Note that the vertical axis has a logarithmic scale.

Tables

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    Table 1:

    Parameters for 1.5T and 3T fetal MRIs

    Fetal Sequences
    1.5T, 3 planes, T2WI SSFSE
        Free-breathing
        TR/TE, 3000/87.8 ms, ST = 4 mm
        FOV, 340 × 340 mm2
        Matrix, 320 × 224 px2
        Time, 22.4 seconds
    1.5T, 3 planes, steady-state FIESTA
        Free-breathing
        TR/TE, 3700/160 ms, ST = 4 mm
        FOV, 34 × 34 mm2
        Matrix, 320 × 224 px2
        Time, 25 seconds
    3T, 3 planes, T2WI SSFSE
        Free-breathing
        TR/TE, 1400/96 ms, ST = 3 mm
        FOV, 280 × 280 mm2
        Matrix, 320 × 288 px2
        Time, 22.4 seconds
    • Note:—SSFSE indicates single-shot FSE; px, pixel; ST, section thickness.

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    Table 2:

    Frequency of scores within magnet type, including both readers

    Magnet Score
    0123
    1.5T74237317108
    10.1%32.2%43.1%14.7%
    3T2071152309
    3.6%12.9%27.5%56.0%
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    Table 3:

    Median IQR signal intensity ratio by location and magnet

    Location1.5T3T
    Germinal7.3 (4.8–19.4)72.3 (49.5–100.6)
    Periventricular layer10.7 (6.2–21.1)103.8 (54.9–181.7)
    Subplate12.0 (8.4–25.4)165.2 (97.2–270.1)
    Cortical9.7 (5.5–19.5)90.1 (61.7–119.4)
    • Note:—IQR indicates interquartile range.

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American Journal of Neuroradiology: 38 (8)
American Journal of Neuroradiology
Vol. 38, Issue 8
1 Aug 2017
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Cite this article
G. Priego, N.J. Barrowman, J. Hurteau-Miller, E. Miller
Does 3T Fetal MRI Improve Image Resolution of Normal Brain Structures between 20 and 24 Weeks' Gestational Age?
American Journal of Neuroradiology Aug 2017, 38 (8) 1636-1642; DOI: 10.3174/ajnr.A5251

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Does 3T Fetal MRI Improve Image Resolution of Normal Brain Structures between 20 and 24 Weeks' Gestational Age?
G. Priego, N.J. Barrowman, J. Hurteau-Miller, E. Miller
American Journal of Neuroradiology Aug 2017, 38 (8) 1636-1642; DOI: 10.3174/ajnr.A5251
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