Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Getting new auth cookie, if you see this message a lot, tell someone!
Research ArticleAdult Brain
Open Access

APOE*E4 Is Associated with Gray Matter Loss in the Posterior Cingulate Cortex in Healthy Elderly Controls Subsequently Developing Subtle Cognitive Decline

S. Haller, M.-L. Montandon, C. Rodriguez, M. Ackermann, F.R. Herrmann and P. Giannakopoulos
American Journal of Neuroradiology July 2017, 38 (7) 1335-1342; DOI: https://doi.org/10.3174/ajnr.A5184
S. Haller
aFrom the Affidea Centre de Diagnostic Radiologique de Carouge (S.H.), Geneva, Switzerland
bFaculty of Medicine (S.H., M.-L.M., F.R.H., P.G.), University of Geneva, Switzerland
cDepartments of Surgical Sciences and Radiology (S.H.), Uppsala University, Uppsala, Sweden
dDepartment of Neuroradiology (S.H.), University Hospital Freiburg, Freiburg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for S. Haller
M.-L. Montandon
bFaculty of Medicine (S.H., M.-L.M., F.R.H., P.G.), University of Geneva, Switzerland
eDepartment of Mental Health and Psychiatry (M.-L.M., M.A.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M.-L. Montandon
C. Rodriguez
fDivision of Institutional Measures, Medical Direction (C.R., P.G.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for C. Rodriguez
M. Ackermann
eDepartment of Mental Health and Psychiatry (M.-L.M., M.A.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M. Ackermann
F.R. Herrmann
bFaculty of Medicine (S.H., M.-L.M., F.R.H., P.G.), University of Geneva, Switzerland
gDivision of Geriatrics, Department of Internal Medicine, Rehabilitation and Geriatrics (F.R.H.), University Hospitals of Geneva, Geneva, Switzerland.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for F.R. Herrmann
P. Giannakopoulos
bFaculty of Medicine (S.H., M.-L.M., F.R.H., P.G.), University of Geneva, Switzerland
fDivision of Institutional Measures, Medical Direction (C.R., P.G.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for P. Giannakopoulos
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Corder EH,
    2. Saunders AM,
    3. Strittmatter WJ, et al
    . Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993;261:921–23 doi:10.1126/science.8346443 pmid:8346443
    Abstract/FREE Full Text
  2. 2.↵
    1. Strittmatter WJ,
    2. Saunders AM,
    3. Schmechel D, et al
    . Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci U S A 1993;90:1977–81 doi:10.1073/pnas.90.5.1977 pmid:8446617
    Abstract/FREE Full Text
  3. 3.↵
    1. Jack CR Jr.,
    2. Therneau TM,
    3. Wiste HJ, et al
    . Transition rates between amyloid and neurodegeneration biomarker states and to dementia: a population-based, longitudinal cohort study. Lancet Neurol 2016;15:56–64 doi:10.1016/S1474-4422(15)00323-3 pmid:26597325
    CrossRefPubMed
  4. 4.↵
    1. Jack CR Jr.,
    2. Wiste HJ,
    3. Weigand SD, et al
    . Age-specific population frequencies of cerebral β-amyloidosis and neurodegeneration among people with normal cognitive function aged 50–89 years: a cross-sectional study. Lancet Neurol 2014;13:997–1005 doi:10.1016/S1474-4422(14)70194-2 pmid:25201514
    CrossRefPubMedWeb of Science
  5. 5.↵
    1. Lee YM,
    2. Ha JK,
    3. Park JM, et al
    . Impact of apolipoprotein E4 polymorphism on the gray matter volume and the white matter integrity in subjective memory impairment without white matter hyperintensities: voxel-based morphometry and Tract-Based Spatial Statistics Study under 3-Tesla MRI. J Neuroimaging 2016;26:144–49 doi:10.1111/jon.12207 pmid:25678236
    CrossRefPubMed
  6. 6.↵
    1. Li B,
    2. Shi J,
    3. Gutman BA, et al
    . Influence of APOE genotype on hippocampal atrophy over time: an N=1925 surface-based ADNI study. PLoS One 2016;11:e0152901 doi:10.1371/journal.pone.0152901 pmid:27065111
    CrossRefPubMed
  7. 7.↵
    1. Shi J,
    2. Leporé N,
    3. Gutman BA, et al
    . Genetic influence of apolipoprotein E4 genotype on hippocampal morphometry: an N = 725 surface-based Alzheimer's disease neuroimaging initiative study. Hum Brain Mapp 2014;35:-3903–18 doi:10.1002/hbm.22447 pmid:24453132
    CrossRefPubMed
  8. 8.↵
    1. Goñi J,
    2. Cervantes S,
    3. Arrondo G, et al
    . Selective brain gray matter atrophy associated with APOE ε4 and MAPT H1 in subjects with mild cognitive impairment. J Alzheimers Dis 2013;33:1009–19 doi:10.3233/JAD-2012-121174 pmid:23064258
    CrossRefPubMed
  9. 9.↵
    1. Lu PH,
    2. Thompson PM,
    3. Leow A, et al
    . Apolipoprotein E genotype is associated with temporal and hippocampal atrophy rates in healthy elderly adults: a tensor-based morphometry study. J Alzheimers Dis 2011;23:433–42 doi:10.3233/JAD-2010-101398 pmid:21098974
    CrossRefPubMed
  10. 10.↵
    1. Honea RA,
    2. Vidoni E,
    3. Harsha A, et al
    . Impact of APOE on the healthy aging brain: a voxel-based MRI and DTI study. J Alzheimers Dis 2009;18:553–64 pmid:19584447
    CrossRefPubMedWeb of Science
  11. 11.↵
    1. Agosta F,
    2. Vossel KA,
    3. Miller BL, et al
    . Apolipoprotein E epsilon4 is associated with disease-specific effects on brain atrophy in Alzheimer's disease and frontotemporal dementia. Proc Natl Acad Sci U S A 2009;106:2018–22 pmid:1916476122
    Abstract/FREE Full Text
  12. 12.↵
    1. Wishart HA,
    2. Saykin AJ,
    3. McAllister TW, et al
    . Regional brain atrophy in cognitively intact adults with a single APOE epsilon4 allele. Neurology 2006;67:1221–24 doi:10.1212/01.wnl.0000238079.00472.3a pmid:17030756
    Abstract/FREE Full Text
  13. 13.↵
    1. Pennanen C,
    2. Testa C,
    3. Boccardi M, et al
    . The effect of apolipoprotein polymorphism on brain in mild cognitive impairment: a voxel-based morphometric study. Dement Geriatr Cogn Disord 2006;22:60–66 doi:10.1159/000093263 pmid:16682795
    CrossRefPubMed
  14. 14.↵
    1. Liu Y,
    2. Paajanen T,
    3. Westman E, et al
    . Effect of APOE ε4 allele on cortical thicknesses and volumes: the AddNeuroMed study. J Alzheimers Dis 2010;21:947–66 doi:10.3233/JAD-2010-100201 pmid:20693633
    CrossRefPubMedWeb of Science
  15. 15.↵
    1. Lupton MK,
    2. Strike L,
    3. Hansell NK, et al
    . The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume. Neurobiol Aging 2016;40:68–77 doi:10.1016/j.neurobiolaging.2015.12.023 pmid:26973105
    CrossRefPubMed
  16. 16.↵
    1. Wang X,
    2. Wang J,
    3. He Y, et al
    . Apolipoprotein E ε4 modulates cognitive profiles, hippocampal volume, and resting-state functional connectivity in Alzheimer's disease. J Alzheimers Dis 2015;45:781–95 doi:10.3233/JAD-142556 pmid:25624419
    CrossRefPubMed
  17. 17.↵
    1. Susanto TA,
    2. Pua EP,
    3. Zhou J, et al
    . Cognition, brain atrophy, and cerebrospinal fluid biomarkers changes from preclinical to dementia stage of Alzheimer's disease and the influence of apolipoprotein e. J Alzheimers Dis 2015;45:-253–68 doi:10.3233/JAD-142451 pmid:2552495
    CrossRefPubMed
  18. 18.↵
    1. Chen J,
    2. Shu H,
    3. Wang Z, et al
    . The interaction of APOE genotype by age in amnestic mild cognitive impairment: a voxel-based morphometric study. J Alzheimers Dis 2015;43:657–68 doi:10.3233/JAD-141677 pmid:25114090
    CrossRefPubMed
  19. 19.↵
    1. Chen Y,
    2. Chen K,
    3. Zhang J, et al
    . Disrupted functional and structural networks in cognitively normal elderly subjects with the APOE ε4 allele. Neuropsychopharmacology 2015;40:1181–91 doi:10.1038/npp.2014.302 pmid:25403724
    CrossRefPubMed
  20. 20.↵
    1. Habes M,
    2. Toledo JB,
    3. Resnick SM, et al
    . Relationship between APOE genotype and structural MRI measures throughout adulthood in the study of health in Pomerania population-based cohort. AJNR Am J Neuroradiol 2016;37:1636–42 doi:10.3174/ajnr.A4805 pmid:27173368
    Abstract/FREE Full Text
  21. 21.↵
    1. Matura S,
    2. Prvulovic D,
    3. Jurcoane A, et al
    . Differential effects of the ApoE4 genotype on brain structure and function. Neuroimage 2014;89:81–91 doi:10.1016/j.neuroimage.2013.11.042 pmid:24296331
    CrossRefPubMed
  22. 22.↵
    1. Shaw P,
    2. Lerch JP,
    3. Pruessner JC, et al
    . Cortical morphology in children and adolescents with different apolipoprotein E gene polymorphisms: an observational study. Lancet Neurol 2007;6:494–500 doi:10.1016/S1474-4422(07)70106-0 pmid:17509484
    CrossRefPubMedWeb of Science
  23. 23.↵
    1. O'Dwyer L,
    2. Lamberton F,
    3. Matura S, et al
    . Reduced hippocampal volume in healthy young ApoE4 carriers: an MRI study. PLoS One 2012;7:e48895 doi:10.1371/journal.pone.0048895 pmid:23152815
    CrossRefPubMed
  24. 24.↵
    1. Hämäläinen A,
    2. Grau-Olivares M,
    3. Tervo S, et al
    . Apolipoprotein E epsilon 4 allele is associated with increased atrophy in progressive mild cognitive impairment: a voxel-based morphometric study. Neurodegener Dis 2008;5:186–89 doi:10.1159/000113698 pmid:18322386
    CrossRefPubMed
  25. 25.↵
    1. Risacher SL,
    2. Shen L,
    3. West JD, et al
    ; Alzheimer's Disease Neuroimaging Initiative (ADNI). Longitudinal MRI atrophy biomarkers: relationship to conversion in the ADNI cohort. Neurobiol Aging 2010;31:1401–18 doi:10.1016/j.neurobiolaging.2010.04.029 pmid:20620664
    CrossRefPubMedWeb of Science
  26. 26.↵
    1. Folstein MF,
    2. Folstein SE,
    3. McHugh PR
    . “Mini-mental state”: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189–98 doi:10.1016/0022-3956(75)90026-6 pmid:1202204
    CrossRefPubMedWeb of Science
  27. 27.↵
    1. Zigmond AS,
    2. Snaith RP
    . The hospital anxiety and depression scale. Acta Psychiatr Scand 1983;67:361–70 doi:10.1111/j.1600-0447.1983.tb09716.x pmid:6880820
    CrossRefPubMedWeb of Science
  28. 28.↵
    1. Barberger-Gateau P,
    2. Commenges D,
    3. Gagnon M, et al
    . Instrumental activities of daily living as a screening tool for cognitive impairment and dementia in elderly community dwellers. J Am Geriatr Soc 1992;40:1129–34 doi:10.1111/j.1532-5415.1992.tb01802.x pmid:1401698
    CrossRefPubMedWeb of Science
  29. 29.↵
    1. Wechsler DA
    . Wechsler Memory Scale. 3rd ed. San Antonio: Psychological Corporation; 1987
  30. 30.↵
    1. Reitan RM
    . Validity of the Trail Making Test as an indicator of organic brain damage. Percept Mot Skills 1958;8:271–76
    CrossRef
  31. 31.↵
    1. Wechsler D
    . Manual for the Wechsler Adult Intelligence Scale. New York: Psychological Corporation; 1995
  32. 32.↵
    1. Milner B
    . Interhemispheric differences in the localization of psychological processes in man. Br Med Bull 1971;27:272–77 doi:10.1093/oxfordjournals.bmb.a070866 pmid:4937273
    FREE Full Text
  33. 33.↵
    1. Buschke H,
    2. Sliwinski MJ,
    3. Kuslansky G, et al
    . Diagnosis of early dementia by the Double Memory Test: encoding specificity improves diagnostic sensitivity and specificity. Neurology 1997;48:989–97 doi:10.1212/WNL.48.4.989 pmid:9109889
    Abstract/FREE Full Text
  34. 34.↵
    1. Baddley A,
    2. Emslie H,
    3. Nimmo-Smith I
    . Doors and People. A Test of Visual and Verbal Recall and Recognition. Bury St. Edmunds: Thames Valley Test Company; 1994
  35. 35.↵
    1. Kaplan EF,
    2. Goodglass H,
    3. Weintraub S
    . The Boston Naming Test. 2nd ed. Philadelphia: Lea & Febiger; 1983
  36. 36.↵
    1. Schnider A,
    2. Hanlon RE,
    3. Alexander DN, et al
    . Ideomotor apraxia: behavioral dimensions and neuroanatomical basis. Brain Lang 1997;58:125–36 doi:10.1006/brln.1997.1770 pmid:9184099
    CrossRefPubMedWeb of Science
  37. 37.↵
    1. Roy EA
    1. Poeck K
    . Clues to the nature of disruption to limb Praxis. In: Roy EA, ed. Neuropsychological Studies of Apraxia and related Disorders. Amsterdam: North-Holland; 1985:99–109
  38. 38.↵
    1. Welsh KA,
    2. Butters N,
    3. Mohs RC, et al
    . The Consortium to Establish a Registry for Alzheimer's Disease (CERAD), Part V: a normative study of the neuropsychological battery. Neurology 1994;44:609–14 doi:10.1212/WNL.44.4.609 pmid:8164812
    Abstract/FREE Full Text
  39. 39.↵
    1. Hughes CP,
    2. Berg L,
    3. Danziger WL, et al
    . A new clinical scale for the staging of dementia. Br J Psychiatry 1982;140:566–72 doi:10.1192/bjp.140.6.566 pmid:7104545
    Abstract/FREE Full Text
  40. 40.↵
    1. Petersen RC,
    2. Doody R,
    3. Kurz A, et al
    . Current concepts in mild cognitive impairment. Arch Neurol 2001;58:1985–92 doi:10.1001/archneur.58.12.1985 pmid:11735772
    CrossRefPubMedWeb of Science
  41. 41.↵
    1. Xekardaki A,
    2. Rodriguez C,
    3. Montandon ML, et al
    . Arterial spin labeling may contribute to the prediction of cognitive deterioration in healthy elderly individuals. Radiology 2015;274:490–99 doi:10.1148/radiol.14140680 pmid:25291458
    CrossRefPubMed
  42. 42.↵
    1. Nauck M,
    2. Hoffmann MM,
    3. Wieland H, et al
    . Evaluation of the apo E genotyping kit on the LightCycler. Clin Chem 2000;46:722–24 pmid:10794760
    FREE Full Text
  43. 43.↵
    1. Smith SM,
    2. Nichols TE
    . Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. Neuroimage 2009;44:83–98 doi:10.1016/j.neuroimage.2008.03.061 pmid:18501637
    CrossRefPubMedWeb of Science
  44. 44.↵
    1. Fouquet M,
    2. Besson FL,
    3. Gonneaud J, et al
    . Imaging brain effects of APOE4 in cognitively normal individuals across the lifespan. Neuropsychol Rev 2014;24:290–99 doi:10.1007/s11065-014-9263-8 pmid:25146994
    CrossRefPubMed
  45. 45.↵
    1. Teipel S,
    2. Grothe MJ
    ; Alzheimer's Disease Neuroimaging Initiative. Does posterior cingulate hypometabolism result from disconnection or local pathology across preclinical and clinical stages of Alzheimer's disease. Eur J Nucl Med Mol Imaging 2016;43:526–36 doi:10.1007/s00259-015-3222-3 pmid:26555082
    CrossRefPubMed
  46. 46.↵
    1. Chételat G,
    2. Ossenkoppele R,
    3. Villemagne VL, et al
    . Atrophy, hypometabolism and clinical trajectories in patients with amyloid-negative Alzheimer's disease. Brain 2016;139:2528–39 doi:10.1093/brain/aww159 pmid:27357349
    Abstract/FREE Full Text
  47. 47.↵
    1. Raji CA,
    2. Lopez OL,
    3. Kuller LH, et al
    . White matter lesions and brain gray matter volume in cognitively normal elders. Neurobiol Aging 2012;33:-834.e7–16 doi:10.1016/j.neurobiolaging.2011.08.010 pmid:21943959
    CrossRefPubMed
  48. 48.↵
    1. Perkins M,
    2. Wolf AB,
    3. Chavira B, et al
    . Altered energy metabolism pathways in the posterior cingulate in young adult apolipoprotein E ε4 carriers. J Alzheimers Dis 2016;53:95–106 doi:10.3233/JAD-151205 pmid:21943959
    CrossRefPubMed
  49. 49.↵
    1. Lu H,
    2. Fung AW,
    3. Chan SS, et al
    . Disturbance of attention network functions in Chinese healthy older adults: an intra-individual perspective. Int Psychogeriatr 2016;28:291–301 doi:10.1017/S1041610215001556 pmid:26412555
    CrossRefPubMed
  50. 50.↵
    1. Albert MS,
    2. DeKosky ST,
    3. Dickson D, et al
    . The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011;7:270–79 doi:10.1016/j.jalz.2011.03.008 pmid:21514249
    CrossRefPubMedWeb of Science
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 38 (7)
American Journal of Neuroradiology
Vol. 38, Issue 7
1 Jul 2017
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
APOE*E4 Is Associated with Gray Matter Loss in the Posterior Cingulate Cortex in Healthy Elderly Controls Subsequently Developing Subtle Cognitive Decline
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
S. Haller, M.-L. Montandon, C. Rodriguez, M. Ackermann, F.R. Herrmann, P. Giannakopoulos
APOE*E4 Is Associated with Gray Matter Loss in the Posterior Cingulate Cortex in Healthy Elderly Controls Subsequently Developing Subtle Cognitive Decline
American Journal of Neuroradiology Jul 2017, 38 (7) 1335-1342; DOI: 10.3174/ajnr.A5184

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
APOE*E4 Is Associated with Gray Matter Loss in the Posterior Cingulate Cortex in Healthy Elderly Controls Subsequently Developing Subtle Cognitive Decline
S. Haller, M.-L. Montandon, C. Rodriguez, M. Ackermann, F.R. Herrmann, P. Giannakopoulos
American Journal of Neuroradiology Jul 2017, 38 (7) 1335-1342; DOI: 10.3174/ajnr.A5184
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • The impact of APOE {varepsilon}4 in Alzheimers disease: a meta-analysis of voxel-based morphometry studies
  • Absolute Winding Number Differentiates Spatial Navigation Strategies with Genetic Risk for Alzheimers Disease
  • Apolipoprotein E genotype and MRI-detected brain alterations pertaining to neurodegeneration: A systematic review
  • Brain Perfusion Measurements Using Multidelay Arterial Spin-Labeling Are Systematically Biased by the Number of Delays
  • Atypical Localization and Dissociation between Glucose Uptake and Amyloid Deposition in Cognitively Normal APOE*E4 Homozygotic Elders Compared with Patients with Late-Onset Alzheimers Disease
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Diagnostic Neuroradiology of Monoclonal Antibodies
  • Clinical Outcomes After Chiari I Decompression
  • Segmentation of Brain Metastases with BLAST
Show more Adult Brain

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire