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Research ArticleAdult Brain
Open Access

APOE*E4 Is Associated with Gray Matter Loss in the Posterior Cingulate Cortex in Healthy Elderly Controls Subsequently Developing Subtle Cognitive Decline

S. Haller, M.-L. Montandon, C. Rodriguez, M. Ackermann, F.R. Herrmann and P. Giannakopoulos
American Journal of Neuroradiology July 2017, 38 (7) 1335-1342; DOI: https://doi.org/10.3174/ajnr.A5184
S. Haller
aFrom the Affidea Centre de Diagnostic Radiologique de Carouge (S.H.), Geneva, Switzerland
bFaculty of Medicine (S.H., M.-L.M., F.R.H., P.G.), University of Geneva, Switzerland
cDepartments of Surgical Sciences and Radiology (S.H.), Uppsala University, Uppsala, Sweden
dDepartment of Neuroradiology (S.H.), University Hospital Freiburg, Freiburg, Germany
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M.-L. Montandon
bFaculty of Medicine (S.H., M.-L.M., F.R.H., P.G.), University of Geneva, Switzerland
eDepartment of Mental Health and Psychiatry (M.-L.M., M.A.)
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C. Rodriguez
fDivision of Institutional Measures, Medical Direction (C.R., P.G.)
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M. Ackermann
eDepartment of Mental Health and Psychiatry (M.-L.M., M.A.)
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F.R. Herrmann
bFaculty of Medicine (S.H., M.-L.M., F.R.H., P.G.), University of Geneva, Switzerland
gDivision of Geriatrics, Department of Internal Medicine, Rehabilitation and Geriatrics (F.R.H.), University Hospitals of Geneva, Geneva, Switzerland.
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P. Giannakopoulos
bFaculty of Medicine (S.H., M.-L.M., F.R.H., P.G.), University of Geneva, Switzerland
fDivision of Institutional Measures, Medical Direction (C.R., P.G.)
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    Fig 1.

    Whole-brain voxel-based morphometry analysis demonstrating higher GM density for the comparison of APOE*E3 > APOE*E4 in the posterior cingulate cortex. P < .05 corrected.

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    Fig 2.

    ROI analysis of GM density depending on APOE status for the 7 target regions for all elderly controls (left-hand side) and separately for subjects with sCON and dCON (right-hand side). One asterisk indicates P < .05; 2 asterisks, P < .01; 3 asterisks, P < .001; 4 asterisks, P < .0001.

Tables

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    Table 1:

    Essential demographic data of the included study groups of stable and deteriorating elderly control participantsa

    GroupsCON AllelesdCON AllelesAPOE Allele Effect 3/3 vs 3/2 (P Value)APOE Allele Effect 4/3 vs 3/2 (P Value)Group Effect (P Value)Interaction 1 (P Value)Interaction 2 (P Value)
    3/23/34/33/23/34/3
    No.22132272114238
    Sex.734.411.172.261.359
        Female13831988626
        Male9498135612
    Education (yr).466.324.676.808.450
        <932343273
        9–128531497220
        >121156994315
    Age (yr).980.969.377.952.539
        Mean73.773.773.874.874.973.9
        SD3.23.94.24.44.24.0
    • ↵a Data in columns 2–7 are number.

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    Table 2:

    ROI analysis of GM concentration in the 7 regions for the comparison of sCON versus dCONa

    sCON versus dCON
    Posterior CingulateHippocampusMesial Temporal CortexParietal LobeOccipital LobeAmygdalaCaudate Nuclei
    APOE*E2 (n = 22/21).0524.3890.4189.8146.4223.3146.2863
    APOE*E3 (n = 132/142).0813.0261b.0756.0349b.2425.2567.1384
    APOE*E4 (n = 27/38).0155b.1916.4076.0316b.2433.5410.3960
    • ↵a Data are P values.

    • ↵b P < .05.

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    Table 3:

    ROI analysis of GM concentration in the 7 regions for the comparison of APOE*E2 versus APOE*E3 and APOE*E2 versus APOE*E4 and APOE*E3 versus APOE*E4

    APOE*E2 versus APOE*E3APOE*E2 versus APOE*E4APOE*E3 versus APOE*E4
    Posterior cingulate
        sCON.7816 (n = 22/132).9153 (n = 22/27).6539 (n = 132/27)
        dCON.1989 (n = 21/142).0004a (n = 22/38).00002b (n = 132/38)
    Hippocampus
        sCONP = .4227P = .3954P = .7191
        dCONP = .2852P = .1937P = .5711
    Mesial temporal lobe
        sCONP = .7285P = .313P = .3601
        dCONP = .9713P = .5361P = .3119
    Parietal lobe
        sCONP = .6977P = .4708P = .1469
        dCONP = .1433P = .2133P = .8734
    Occipital lobe
        sCONP = .0596P = .6834P = .1617
        dCONP = .9744P = .6773P = .4631
    Amygdala
        sCONP = .0025cP = .0083cP = .6342
        dCONP = .4174P = .3411P = .6874
    Caudate nuclei
        sCONP = .2931P = .4369P = .8506
        dCONP = .9051P = .9427P = .9431
    • ↵a P < .001.

    • ↵b P < .0001.

    • ↵c P < .01.

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S. Haller, M.-L. Montandon, C. Rodriguez, M. Ackermann, F.R. Herrmann, P. Giannakopoulos
APOE*E4 Is Associated with Gray Matter Loss in the Posterior Cingulate Cortex in Healthy Elderly Controls Subsequently Developing Subtle Cognitive Decline
American Journal of Neuroradiology Jul 2017, 38 (7) 1335-1342; DOI: 10.3174/ajnr.A5184

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APOE*E4 Is Associated with Gray Matter Loss in the Posterior Cingulate Cortex in Healthy Elderly Controls Subsequently Developing Subtle Cognitive Decline
S. Haller, M.-L. Montandon, C. Rodriguez, M. Ackermann, F.R. Herrmann, P. Giannakopoulos
American Journal of Neuroradiology Jul 2017, 38 (7) 1335-1342; DOI: 10.3174/ajnr.A5184
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