Article Figures & Data
Figures
- Fig 1.
Composite histogram curves from all patients plotting fractions of voxels by voxel intensity in apparent diffusion coefficient maps of controls (line) and subjects with SAH (dots).
- Fig 2.
Composite histogram curves from all patients with SAH plotting the fraction of voxels by voxel intensity in apparent diffusion coefficient maps of patients with SAH with Hunt and Hess 1–3 (line) and Hunt and Hess 4–5 (dots).
Tables
- Table 1:
Summary of admission, demographic, clinical, and radiographic characteristics of patients with SAHa
Patients with SAH (n = 33) Controls (n = 66) P Value Basic and demographic data Age (yr) 59 (44.5–66) 49 (43.4–53.2) <.001b Female sex 16 (48.5%) 41 (62.1%) .196 Race Caucasian 25 (75.8%) 47 (72.3%) .343 Black 8 (24.3%) 14 (21.5%) Other 0 4 (6.2%) History of smoking 21 (63.6%) 34 (51.5%) .253 History of alcohol abuse 7 (22.6%) 10 (15.2%) .370 Hypertension 14 (45.2%) 33 (50.0%) .657 Diabetes 4 (12.9%) 14 (21.2%) .326 Hyperlipidemia 12 (38.7%) 24 (36.4%) .824 Aspirin use 10 (31.3%) 22 (33.3%) .837 History of ischemic stroke 1 (3.0%) 0 – History of intracranial hemorrhage 0 0 – History of head trauma 0 0 – History of brain tumor 0 0 – Family history of aneurysm 4 (13.3%) 0 – Cocaine use within 24 hr of ictus 1 (3.0%) 0 – Admission clinical and radiographic data Premorbid modified Rankin Scale score29 0 (0–0) HH grade12 1 5 (15.2%) 2 14 (42.4%) 3 6 (18.2%) 4 5 (15.2%) 5 3 (9.1%) Glasgow Coma Score 15 (11.5–15) APACHE II score30 7 (3–10) Modified Fisher grade15 1 4 (12.1%) 2 2 (6.1%) 3 18 (54.5%) 4 9 (27.3%) Hijdra sum score31 13.5 (6–21) Cerebral edema on admission CT 8 (25.0%) External ventricular drain placed 14 (42.4%) ROI ADC (×10−6 mm2/s) Control (n = 66) ADC (×10−6 mm2/s) SAH (n = 33) P Value Age-Adjusted P Value Cerebral gray matter 803 (36.2) 826 (37.7) .001b .059 Frontal 802 (65.2) 823 (66.4) .137 Parietal 820 (48.0) 843 (53.5) .025b Occipital 798 (67.7) 814 (51.7) .042b Temporal 791 (43.6) 822 (60.6) .006b Cerebral white matter 758 (33.9) 793 (44.9) .001b .023b Frontal 735 (53.0) 768 (55.8) .007b Parietal 767 (50.9) 799 (51.3) .007b Occipital 764 (36.8) 795 (47.7) .003b Temporal 767 (45.4) 809 (61.8) .003b White matter tracts 739 (33.5) 797 (59.3) <.001b <.001b Genu 761 (45.2) 816 (69.1) <.001b Splenium 736 (45.6) 789 (91.4) <.001b Internal capsule 719 (53.2) 785 (96.4) <.001b Deep gray matter 713 (27.4) 754 (59.6) <.001b .016b Thalamus 730 (45.1) 777 (86.8) .020b Caudate 705 (37.2) 739 (65.7) .002b Lentiform 705 (45.5) 747 (67.5) <.001b Hippocampus 854 (67.7) 878 (64.8) .072 Midbrain 795 (93.5) 813 (47.4) .006b Pons 706 (50.6) 756 (54.6) <.001b Cerebellar gray matter 756 (48.9) 796 (67.7) .001 Cerebellar white matter 720 (50.3) 731 (43.7) .214 Summed ROIs 759 (23.3) 795 (36.9) <.00b <.001b - Table 3:
Average median ADC values in ROIs among patients with SAH with HH 1–3 versus 4–5a
ROI ADC (×10−6 mm2/s) HH 1–3 (n = 25) ADC (×10−6 mm2/s) HH 4–5 (n = 8) P Value Cerebral gray matter 823 (25.9) 833 (64.1) .159 Frontal 821 (60.9) 831 (85.9) .785 Parietal 844 (55.4) 843 (50.6) .753 Occipital 813 (41.0) 819 (80.3) .556 Temporal 816 (52.1) 840 (83.5) .172 Cerebral white matter 787 (43.1) 811 (48.7) .147 Frontal 764 (57.2) 781 (52.6) .425 Parietal 801 (49.8) 792 (58.7) 1.000 Occipital 789 (45.8) 814 (51.6) .115 Temporal 793.5 (55.4) 856 (59.7) .014b White matter tracts 796 (58.4) 798 (66.1) .916 Genu 810 (63.5) 834 (86.6) .401 Splenium 799 (79.1) 758 (123.8) .950 Internal capsule 780 (103.7) 801 (71.9) .401 Deep gray matter 748 (52.1) 773 (80.0) .074 Thalamus 763 (81.4) 820 (94.7) .097 Caudate 737 (57.8) 743 (90.8) .130 Lentiform 744 (64.4) 756 (80.7) .239 Hippocampus 881 (62.9) 870 (74.4) 1.000 Midbrain 811 (43.2) 818 (61.9) .378 Pons 756 (50.3) 756 (70.4) .834 Cerebellar gray matter 794 (75.5) 800 (36.8) .324 Cerebellar white matter 730 (45.6) 732 (39.5) .883 Summed ROIs 792 (31.7) 803 (51.7) .200
