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Research ArticleAdult Brain
Open Access

Improved Leakage Correction for Single-Echo Dynamic Susceptibility Contrast Perfusion MRI Estimates of Relative Cerebral Blood Volume in High-Grade Gliomas by Accounting for Bidirectional Contrast Agent Exchange

K. Leu, J.L. Boxerman, T.F. Cloughesy, A. Lai, P.L. Nghiemphu, L.M. Liau, W.B. Pope and B.M. Ellingson
American Journal of Neuroradiology August 2016, 37 (8) 1440-1446; DOI: https://doi.org/10.3174/ajnr.A4759
K. Leu
aFrom the UCLA Brain Tumor Imaging Laboratory (K.L., B.M.E.), Center for Computer Vision and Imaging Biomarkers
bDepartment of Bioengineering (K.L., B.M.E.), Henry Samueli School of Engineering and Applied Science
dDepartments of Radiological Sciences (K.L., W.B.P., B.M.E.)
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J.L. Boxerman
hDepartment of Diagnostic Imaging (J.L.B.), Rhode Island Hospital and Alpert Medical School of Brown University, Providence, Rhode Island.
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T.F. Cloughesy
cUCLA Neuro-Oncology Program (T.F.C., A.L., P.L.N., B.M.E.), University of California, Los Angeles, Los Angeles, California
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A. Lai
cUCLA Neuro-Oncology Program (T.F.C., A.L., P.L.N., B.M.E.), University of California, Los Angeles, Los Angeles, California
fNeurology (A.L., P.L.N.)
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P.L. Nghiemphu
cUCLA Neuro-Oncology Program (T.F.C., A.L., P.L.N., B.M.E.), University of California, Los Angeles, Los Angeles, California
fNeurology (A.L., P.L.N.)
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L.M. Liau
gNeurosurgery (L.M.L.), David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California
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W.B. Pope
dDepartments of Radiological Sciences (K.L., W.B.P., B.M.E.)
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B.M. Ellingson
aFrom the UCLA Brain Tumor Imaging Laboratory (K.L., B.M.E.), Center for Computer Vision and Imaging Biomarkers
bDepartment of Bioengineering (K.L., B.M.E.), Henry Samueli School of Engineering and Applied Science
cUCLA Neuro-Oncology Program (T.F.C., A.L., P.L.N., B.M.E.), University of California, Los Angeles, Los Angeles, California
dDepartments of Radiological Sciences (K.L., W.B.P., B.M.E.)
eBiomedical Physics (B.M.E.)
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American Journal of Neuroradiology: 37 (8)
American Journal of Neuroradiology
Vol. 37, Issue 8
1 Aug 2016
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Cite this article
K. Leu, J.L. Boxerman, T.F. Cloughesy, A. Lai, P.L. Nghiemphu, L.M. Liau, W.B. Pope, B.M. Ellingson
Improved Leakage Correction for Single-Echo Dynamic Susceptibility Contrast Perfusion MRI Estimates of Relative Cerebral Blood Volume in High-Grade Gliomas by Accounting for Bidirectional Contrast Agent Exchange
American Journal of Neuroradiology Aug 2016, 37 (8) 1440-1446; DOI: 10.3174/ajnr.A4759

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Improved Leakage Correction for Single-Echo Dynamic Susceptibility Contrast Perfusion MRI Estimates of Relative Cerebral Blood Volume in High-Grade Gliomas by Accounting for Bidirectional Contrast Agent Exchange
K. Leu, J.L. Boxerman, T.F. Cloughesy, A. Lai, P.L. Nghiemphu, L.M. Liau, W.B. Pope, B.M. Ellingson
American Journal of Neuroradiology Aug 2016, 37 (8) 1440-1446; DOI: 10.3174/ajnr.A4759
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Cited By...

  • "Synthetic" DSC Perfusion MRI with Adjustable Acquisition Parameters in Brain Tumors Using Dynamic Spin-and-Gradient-Echo Echoplanar Imaging
  • Pseudo-Resting-State Functional MRI Derived from Dynamic Susceptibility Contrast Perfusion MRI Can Predict Cognitive Impairment in Glioma
  • Multiparametric MR-PET Imaging Predicts Pharmacokinetics and Clinical Response to GDC-0084 in Patients with Recurrent High-Grade Glioma
  • Optimization of Acquisition and Analysis Methods for Clinical Dynamic Susceptibility Contrast MRI Using a Population-Based Digital Reference Object
  • Detection of immune responses after immunotherapy in glioblastoma using PET and MRI
  • Effects of MRI Protocol Parameters, Preload Injection Dose, Fractionation Strategies, and Leakage Correction Algorithms on the Fidelity of Dynamic-Susceptibility Contrast MRI Estimates of Relative Cerebral Blood Volume in Gliomas
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