Improved Leakage Correction for Single-Echo Dynamic Susceptibility Contrast Perfusion MRI Estimates of Relative Cerebral Blood Volume in High-Grade Gliomas by Accounting for Bidirectional Contrast Agent Exchange

^aFrom the UCLA Brain Tumor Imaging Laboratory (K.L., B.M.E.), Center for Computer Vision and Imaging Biomarkers
^bDepartment of Bioengineering (K.L., B.M.E.), Henry Samueli School of Engineering and Applied Science
^cUCLA Neuro-Oncology Program (T.F.C., A.L., P.L.N., B.M.E.), University of California, Los Angeles, Los Angeles, California
^dDepartments of Radiological Sciences (K.L., W.B.P., B.M.E.)
^eBiomedical Physics (B.M.E.)
^fNeurology (A.L., P.L.N.)
^gNeurosurgery (L.M.L.), David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California
^hDepartment of Diagnostic Imaging (J.L.B.), Rhode Island Hospital and Alpert Medical School of Brown University, Providence, Rhode Island.

Please address correspondence to Benjamin M. Ellingson, PhD, UCLA Brain Tumor Imaging Laboratory, Departments of Radiological Sciences and Psychiatry, David Geffen School of Medicine, University of California, Los Angeles, 924 Westwood Blvd, Suite 615, Los Angeles, CA 90024; e-mail: bellingson{at}mednet.ucla.edu; @ben_ellingson