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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticlePediatric Neuroimaging
Open Access

Full Dose-Reduction Potential of Statistical Iterative Reconstruction for Head CT Protocols in a Predominantly Pediatric Population

A.E. Mirro, S.L. Brady and R.A. Kaufman
American Journal of Neuroradiology July 2016, 37 (7) 1199-1205; DOI: https://doi.org/10.3174/ajnr.A4754
A.E. Mirro
aFrom the Department of Biomedical Engineering (A.E.M.), Washington University, St. Louis, Missouri
bDepartment of Diagnostic Imaging (A.E.M. S.L.B., R.A.K.), St Jude Children's Research Hospital, Memphis, Tennessee.
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S.L. Brady
bDepartment of Diagnostic Imaging (A.E.M. S.L.B., R.A.K.), St Jude Children's Research Hospital, Memphis, Tennessee.
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R.A. Kaufman
bDepartment of Diagnostic Imaging (A.E.M. S.L.B., R.A.K.), St Jude Children's Research Hospital, Memphis, Tennessee.
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  • Fig 1.
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    Fig 1.

    Texture of image noise as it appears in reconstructed images changes as the mean of the NPS curve shifts along the abscissa; shifts in mean NPS frequency are associated with changes in the appearance of image noise texture. A, NPS curves of the standard reconstruction kernel are reconstructed at 3 levels of ASIR. B, A corresponding ROI of 128 × 128 pixels from the center of a water phantom shows the appearance of the noise texture as it correlates with a 32% shift in NPS mean frequency along the abscissa from curve A to B and a 52% shift in curve A to C.

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    Fig 2.

    Dose-reduced ASIR protocols compare the mean NPS frequency shift (A) as a function of the level of ASIR reconstruction. An acceptable tolerance for the appearance of noise texture in the reconstructed image is reported in the literature,4,5,20,21 based on a 25% shift of NPS noise frequency (dashed line). B, Corresponding reductions of CTDIvol for the protocols by using ASIR are plotted and fit by using a log-regression function.

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    Fig 3.

    Noise power spectra acquired with the soft reconstruction kernel at 100 kVp from 240 to 120 mA (A), with the soft reconstruction kernel at 120 kVp from 200 to 110 mA (B), and the standard reconstruction kernel at 100 kVp from 250 to 140 mA (C). The calculated spectra are reconstructed at 0%–60% ASIR (soft reconstruction kernel) and at 0%–40% ASIR (standard reconstruction kernel).

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    Fig 4.

    Images of the 3-, 5-, 7-, and 9-mm low-contrast targets in the Catphan 700 phantom are acquired with FBP and dose-reduced ASIR reconstruction up to 60% ASIR for the soft reconstruction kernels at both 100 and 120 kVp and up to 40% for the standard reconstruction kernel at 100 kVp.

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    Fig 5.

    A 3-year-old boy with scans 6 months apart. A, The original brain protocol is acquired at 200 mA and 100 kVp with a CTDIvol of 25.1 mGy by using FBP. B, The patient is re-examined postsurgery with the dose-reduced brain protocol by using 60% ASIR, 120 mA, and 100 kVp, with a CTDIvol of 15.0 mGy. Both examinations were acquired by using the GE Healthcare soft reconstruction kernel.

Tables

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    Table 1:

    Head CT examination parametersa

    Patient Age (yr)A or HRotation (sec)Collimation (mm)Section (mm)Reconstruction KernelkVpPre-ASIR (mA)Post-ASIR (mA)
    Brain
        0–2bA0.5205Soft and bone100280150
        2–51200120
        6–10220130
        11–18240140
        ≥19120200105
    Sinus
        ≥19H0.5402.5Soft and bone120NI = 7.5155
        0–18100220130
    Orbits
        0–18cHd0.5201.25Standard and bone100240155
    Temporal bone
        ≥19H1201.25Standard and bone120250150
        2–180.5120400230
    Maxillary bone
        ≥19Hd0.5202.5Standard and bone120NI = 7.5NI = 9.25
        0–18H100300180
    • Note:—A indicates axial; H, helical; NI, Noise Index; SFOV, scan FOV.

    • ↵a All protocols were imaged with a SFOV using “Head” unless otherwise indicated. All helical acquisitions were scanned with a pitch of 0.984 unless otherwise indicated.

    • ↵b SFOV used “Ped Head.”

    • ↵c SFOV used “Small Head.”

    • ↵d Pitch = 0.516.

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    Table 2:

    Original and dose-reduced CTDIvol and noise values for all head protocols

    Patient Age CategoryProtocolCTDIvol (mGy)Noise (HU)
    OriginalDose-ReducedDifferenceOriginalDose-ReducedDifference
    0–23 moBrain15.0 ± 0.78.0 ± 0.4−47%4.4 ± 1.04.2 ± 0.7−3%
    2–5 yrBrain24.1 ± 0.914.6 ± 0.6−39%4.2 ± 0.74.1 ± 0.7−3%
    6–10 yrBrain26.3 ± 1.315.9 ± 0.4−40%4.1 ± 0.54.2 ± 0.64%
    11–18 yrBrain29.1 ± 0.917.0 ± 0.5−42%4.4 ± 0.64.5 ± 0.63%
    ≥ 19 yrBrain36.6 ± 0.818.9 ± 0.5−48%4.3 ± 0.64.4 ± 0.43%
    0–18 yrMaxilla19.4 ± 0.011.5 ± 0.1−41%11.2 ± 2.811.6 ± 1.63%
    ≥19 yrMaxilla22.8 ± 0.018.7 ± 0.2−18%9.6 ± 1.49.2 ± 1.7−3%
    0–18 yrOrbits26.9 ± 8.015.8 ± 0.5−41%7.5 ± 1.27.2 ± 0.1−4%
    0–18 yrSinus13.1 ± 0.07.2 ± 0.3−45%8.5 ± 1.28.9 ± 1.15%
    ≥19 yrSinus22.8 ± 0.013.7 ± 0.1−40%8.3 ± 0.98.2 ± 0.6−1%
    2–18 yrTemporal40.7 ± 0.022.8 ± 0.0−44%9.3 ± 1.49.2 ± 1.2−2%
    ≥19 yraTemporal49.9 ± 0.029.7 ± 0.0−40%9.3 ± 1.0
    • ↵a No dose-reduced patient examinations were available for comparison. Dose-reduced CTDIvol value is calculated on the basis of scan parameters. Dose difference is a theoretic calculation.

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American Journal of Neuroradiology: 37 (7)
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Cite this article
A.E. Mirro, S.L. Brady, R.A. Kaufman
Full Dose-Reduction Potential of Statistical Iterative Reconstruction for Head CT Protocols in a Predominantly Pediatric Population
American Journal of Neuroradiology Jul 2016, 37 (7) 1199-1205; DOI: 10.3174/ajnr.A4754

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Full Dose-Reduction Potential of Statistical Iterative Reconstruction for Head CT Protocols in a Predominantly Pediatric Population
A.E. Mirro, S.L. Brady, R.A. Kaufman
American Journal of Neuroradiology Jul 2016, 37 (7) 1199-1205; DOI: 10.3174/ajnr.A4754
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