Detection of Normal Aging Effects on Human Brain Metabolite Concentrations and Microstructure with Whole-Brain MR Spectroscopic Imaging and Quantitative MR Imaging

References

1. 1.↵
   2. Haga KK,
   3. Khor YP,
   4. Farrall A, et al

   . A systematic review of brain metabolite changes, measured with 1H magnetic resonance spectroscopy, in healthy aging. Neurobiol Aging 2009;30:353–63 doi:10.1016/j.neurobiolaging.2007.07.005 pmid:17719145

   CrossRefPubMedWeb of Science
2. 2.↵
   2. Barker PB,
   3. Bizzi A,
   4. De Stefano N, et al

   . Clinical MR Spectroscopy: Techniques and Applications. 1st ed. Cambridge: Cambridge University Press, 2009
3. 3.↵
   2. Maudsley AA,
   3. Govind V,
   4. Arheart KL

   . Associations of age, gender and body mass with 1H MR-observed brain metabolites and tissue distributions. NMR Biomed 2012;25:580–93 doi:10.1002/nbm.1775 pmid:21858879

   CrossRefPubMed
4. 4.↵
   2. Ding XQ,
   3. Kucinski T,
   4. Wittkugel O, et al

   . Normal brain maturation characterized with age-related T2 relaxation times: an attempt to develop a quantitative imaging measure for clinical use. Invest Radiol 2004;39:740–46 doi:10.1097/00004424-200412000-00005 pmid:15550835

   CrossRefPubMedWeb of Science
5. 5.↵
   2. Siemonsen S,
   3. Finsterbusch J,
   4. Matschke J, et al

   . Age-dependent normal values of T2* and T2′ in brain parenchyma. AJNR Am J Neuroradiol 2008;29:950–55 doi:10.3174/ajnr.A0951 pmid:18272561

   Abstract/FREE Full Text
6. 6.↵
   2. Sedlacik J,
   3. Boelmans K,
   4. Löbel U, et al

   . Reversible, irreversible and effective transverse relaxation rates in normal aging brain at 3T. Neuroimage 2014;84:1032–41 doi:10.1016/j.neuroimage.2013.08.051 pmid:24004692

   CrossRefPubMed
7. 7.↵
   2. Holst B,
   3. Siemonsen S,
   4. Finsterbusch J, et al

   . T2′ imaging indicates decreased tissue metabolism in frontal white matter of MS patients. Mult Scler 2009;15:701–07 doi:10.1177/1352458509103713 pmid:19482862

   Abstract/FREE Full Text
8. 8.↵
   2. Miszkiel KA,
   3. Paley MN,
   4. Wilkinson ID, et al

   . The measurement of R2, R2* and R2′ in HIV-infected patients using the prime sequence as a measure of brain iron deposition. Magn Reson Imaging 1997;15:1113–19 doi:10.1016/S0730-725X(97)00089-1 pmid:9408132

   CrossRefPubMedWeb of Science
9. 9.↵
   2. Steer RA,
   3. Clark DA,
   4. Beck AT, et al

   . Common and specific dimensions of self-reported anxiety and depression: the BDI-II versus the BDI-IA. Behav Res Ther 1999;37:183–90 doi:10.1016/S0005-7967(98)00087-4 pmid:9990749

   CrossRefPubMedWeb of Science
10. 10.↵
    2. Kalbe E,
    3. Kessler J,
    4. Calabrese P, et al

    . DemTect: a new, sensitive cognitive screening test to support the diagnosis of mild cognitive impairment and early dementia. Int J Geriatr Psychiatry 2004;19:136–43 doi:10.1002/gps.1042 pmid:14758579

    CrossRefPubMedWeb of Science
11. 11.↵
    2. Maudsley AA,
    3. Domenig C,
    4. Sheriff S

    . Reproducibility of serial whole-brain MR spectroscopic imaging. NMR Biomed 2010;23:251–56 doi:10.1002/nbm.1445 pmid:19777506

    CrossRefPubMedWeb of Science
12. 12.↵
    2. Barker PB,
    3. Soher BJ,
    4. Blackband SJ, et al

    . Quantitation of proton NMR spectra of the human brain using tissue water as an internal concentration reference. NMR Biomed 1993;6:89–94 doi:10.1002/nbm.1940060114 pmid:8384470

    CrossRefPubMedWeb of Science
13. 13.↵
    2. Abramoff MD,
    3. Magalhães PJ,
    4. Ram SJ

    . Image processing with ImageJ. Biophotonics International 2004;11:36–42
14. 14.↵
    2. Baker EH,
    3. Basso G,
    4. Barker PB, et al

    . Regional apparent metabolite concentrations in young adult brain measured by (1)H MR spectroscopy at 3 Tesla. J Magn Reson Imaging 2008;27:489–99 doi:10.1002/jmri.21285 pmid:18307197

    CrossRefPubMed
15. 15.↵
    2. Pouwels PJ,
    3. Brockmann K,
    4. Kruse B, et al

    . Regional age dependence of human brain metabolites from infancy to adulthood as detected by quantitative localized proton MRS. Pediatr Res 1999;46:474–85 doi:10.1203/00006450-199910000-00019 pmid:10509371

    CrossRefPubMedWeb of Science
16. 16.↵
    2. Kumar R,
    3. Delshad S,
    4. Woo MA, et al

    . Age-related regional brain T2-relaxation changes in healthy adults. J Magn Reson Imaging 2012;35:300–08 doi:10.1002/jmri.22831 pmid:21987489

    CrossRefPubMed
17. 17.↵
    2. Li W,
    3. Langkammer C,
    4. Chou YH, et al

    . Association between increased magnetic susceptibility of deep gray matter nuclei and decreased motor function in healthy adults. Neuroimage 2015;105:45–52 doi:10.1016/j.neuroimage.2014.10.009 pmid:25315786

    CrossRefPubMed
18. 18.↵
    2. Ryberg C,
    3. Rostrup E,
    4. Paulson OB, et al

    ; LADIS study group. Corpus callosum atrophy as a predictor of age-related cognitive and motor impairment: a 3-year follow-up of the LADIS study cohort. J Neurol Sci 2011;307:100–05 doi:10.1016/j.jns.2011.05.002 pmid:21621224

    CrossRefPubMed
19. 19.↵
    2. Brooks JC,
    3. Roberts N,
    4. Kemp GJ, et al

    . A proton magnetic resonance spectroscopy study of age-related changes in frontal lobe metabolite concentrations. Cereb Cortex 2001;11:598–605 doi:10.1093/cercor/11.7.598 pmid:11415962

    Abstract/FREE Full Text
20. 20.↵
    2. Charles HC,
    3. Lazeyras F,
    4. Krishnan KR, et al

    . Proton spectroscopy of human brain: effects of age and sex. Prog Neuropsychopharmacol Biol Psychiatry 1994;18:995–1004 doi:10.1016/0278-5846(94)90125-2 pmid:7824764

    CrossRefPubMed
21. 21.↵
    2. Chao LL,
    3. Mueller SG,
    4. Buckley ST, et al

    . Evidence of neurodegeneration in brains of older adults who do not yet fulfill MCI criteria. Neurobiol Aging 2010;31:368–77 doi:10.1016/j.neurobiolaging.2008.05.004 pmid:18550226

    CrossRefPubMedWeb of Science
22. 22.↵
    2. Raininko R,
    3. Mattsson P

    . Metabolite concentrations in supraventricular white matter from teenage to early old age: a short echo time 1H magnetic resonance spectroscopy (MRS) study. Acta Radiol 2010;51:309–15 doi:10.3109/02841850903476564 pmid:20170295

    Abstract/FREE Full Text
23. 23.↵
    2. Moreno-Torres A,
    3. Pujol J,
    4. Soriano-Mas C, et al

    . Age-related metabolic changes in the upper brainstem tegmentum by MR spectroscopy. Neurobiol Aging 2005;26:1051–59 doi:10.1016/j.neurobiolaging.2004.09.009 pmid:15748785

    CrossRefPubMedWeb of Science
24. 24.↵
    2. Gruber S,
    3. Pinker K,
    4. Riederer F, et al

    . Metabolic changes in the normal ageing brain: consistent findings from short and long echo time proton spectroscopy. Eur J Radiol 2008;68:320–27 doi:10.1016/j.ejrad.2007.08.038 pmid:17964104

    CrossRefPubMedWeb of Science
25. 25.↵
    2. Holland BA,
    3. Haas DK,
    4. Norman D, et al

    . MRI of normal brain maturation. AJNR Am J Neuroradiol 1986;7:201–08 pmid:3082150

    Abstract/FREE Full Text
26. 26.↵
    2. Dawe RJ,
    3. Bennett DA,
    4. Schneider JA, et al

    . Ex vivo T2 relaxation: associations with age-related neuropathology and cognition. Neurobiol Aging 2014;35:1549–61 doi:10.1016/j.neurobiolaging.2014.01.144 pmid:24582637

    CrossRefPubMed
27. 27.↵
    2. Ding XQ,
    3. Wittkugel O,
    4. Goebell E, et al

    . Clinical applications of quantitative T2 determination: a complementary MRI tool for routine diagnosis of suspected myelination disorders. Eur J Paediatr Neurol 2008;12:298–308 doi:10.1016/j.ejpn.2007.08.012 pmid:17964834

    CrossRefPubMed
28. 28.↵
    2. Weissenborn K,
    3. Bültmann E,
    4. Donnerstag F, et al

    . Quantitative MRI shows cerebral microstructural damage in hemolytic-uremic syndrome patients with severe neurological symptoms but no changes in conventional MRI. Neuroradiology 2013;55:819–25 doi:10.1007/s00234-013-1176-3 pmid:23559401

    CrossRefPubMed
29. 29.↵
    2. Jara H,
    3. Sakai O,
    4. Mankal P, et al

    . Multispectral quantitative magnetic resonance imaging of brain iron stores: a theoretical perspective. Top Magn Reson Imaging 2006;17:19–30 doi:10.1097/01.rmr.0000245460.82782.69 pmid:17179894

    CrossRefPubMed
30. 30.↵
    2. Hallgren B,
    3. Sourander P

    . The effect of age on the non-haemin iron in the human brain. J Neurochem 1958;3:41–51 doi:10.1111/j.1471-4159.1958.tb12607.x pmid:13611557

    CrossRefPubMedWeb of Science
31. 31.↵
    2. Wagner M,
    3. Jurcoane A,
    4. Volz S, et al

    . Age-related changes of cerebral autoregulation: new insights with quantitative T2′-mapping and pulsed arterial spin-labeling MR imaging. AJNR Am J Neuroradiol 2012;33:2081–87 doi:10.3174/ajnr.A3138 pmid:22700750

    Abstract/FREE Full Text
32. 32.↵
    2. Wagner M,
    3. Magerkurth J,
    4. Volz S, et al

    . T2′- and PASL-based perfusion mapping at 3 Tesla: influence of oxygen-ventilation on cerebral autoregulation. J Magn Reson Imaging 2012;36:1347–52 doi:10.1002/jmri.23777 pmid:22911952

    CrossRefPubMed
33. 33.↵
    2. Seals DR,
    3. Jablonski KL,
    4. Donato AJ

    . Aging and vascular endothelial function in humans. Clin Sci (Lond) 2011;120:357–75 doi:10.1042/CS20100476 pmid:21244363

    CrossRefPubMed