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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleAdult Brain
Open Access

Detection of Normal Aging Effects on Human Brain Metabolite Concentrations and Microstructure with Whole-Brain MR Spectroscopic Imaging and Quantitative MR Imaging

V.V. Eylers, A.A. Maudsley, P. Bronzlik, P.R. Dellani, H. Lanfermann and X.-Q. Ding
American Journal of Neuroradiology March 2016, 37 (3) 447-454; DOI: https://doi.org/10.3174/ajnr.A4557
V.V. Eylers
aFrom the Institute of Diagnostic and Interventional Neuroradiology (V.V.E., P.B., P.R.D., H.L., X.-Q.D.), Hannover Medical School, Hannover, Germany
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A.A. Maudsley
bDepartment of Radiology (A.A.M.), University of Miami School of Medicine, Miami, Florida.
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  • ORCID record for A.A. Maudsley
P. Bronzlik
aFrom the Institute of Diagnostic and Interventional Neuroradiology (V.V.E., P.B., P.R.D., H.L., X.-Q.D.), Hannover Medical School, Hannover, Germany
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P.R. Dellani
aFrom the Institute of Diagnostic and Interventional Neuroradiology (V.V.E., P.B., P.R.D., H.L., X.-Q.D.), Hannover Medical School, Hannover, Germany
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H. Lanfermann
aFrom the Institute of Diagnostic and Interventional Neuroradiology (V.V.E., P.B., P.R.D., H.L., X.-Q.D.), Hannover Medical School, Hannover, Germany
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X.-Q. Ding
aFrom the Institute of Diagnostic and Interventional Neuroradiology (V.V.E., P.B., P.R.D., H.L., X.-Q.D.), Hannover Medical School, Hannover, Germany
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  • Fig 1.
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    Fig 1.

    Locations of each selected ROI in the right brain hemisphere displayed as white filled circles on the T2-weighted images, respectively, and sample spectra from the parietal white matter and occipital gray matter of a 31-year-old volunteer. The numbering represents the ROIs in the hand motor cortex (1), centrum semiovale (2), splenium of the corpus callosum (3), cerebellar white matter (4) and posterior lobe (5), brain stem ventral (6) and dorsal (7), frontal white matter (8), putamen (9), pallidum (10), thalamus (11), parietal white matter (pWM, 12), and occipital gray matter (oGM, 13), respectively.

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    Fig 2.

    Group mean values of metabolite concentrations and tissue transverse relaxation times (y axis) with SDs for age group 1 (21–30 years), group 2 (31–40 years), group 3 (41–50 years), group 4 (51–60 years), and group 5 (61–70 years) are shown. The ROIs are as described in Fig 1.

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    Fig 3.

    Values of the metabolite concentrations (top) and tissue transverse relaxation times (bottom) of all subjects measured at the ROIs of occipital GM, putamen, and pallidum drawn according to the age, where NAA and T2′ in the occipital GM and NAA, tCr, and T2′ in the putamen reveal linear reductions with age (P < .01 with the value of each slope being given in the Table), while tCr, Cho, and T2 in the occipital GM and Cho and T2 in putamen do not show an age dependence. No significant age correlations were found in the pallidum both for metabolites and relaxation times, but a significant linear reduction of T2′ with age was found up to 60 years of age (P < .01 with the value of each slope being given in the Table).

Tables

  • Figures
  • Significant associations (P < .01) of the regional metabolite concentrations and transverse relaxation times with age, derived with linear regressions

    ROIParameterMeanaSDRPNo.bInterceptSlopeVariation in 50 Yr (%)c
    Occipital GMNAA13.21.6−0.40.0025915.16−0.04−16
    T2′56.79.4−0.45.0006069.67−0.30−23
    PutamenNAA13.21.5−0.51.0006015.54−0.05−19
    tCr10.21.4−0.39.0026011.89−0.04−17
    T2′55.113.1−0.68.0006083.44−0.66−47
    PallidumdT2′32.36.4−0.34.0054041.53−0.24−26e
    HKT2′63.610.5−0.35.0076076.72−0.28−20
    SCCNAA10.91.9−0.36.0056013.01−0.05−19
    T2105.19.3−0.47.00060118.50−0.31−14
    T2′57.57.40.40.0026045.140.3635
    CbWMT2120.58.30.45.00060108.930.2612
    BSvNAA13.42.4−0.42.0035016.73−0.08−26
    BSdtCr9.21.3−0.35.0105310.64−0.03−16
    • Note:—R indicates the Pearson correlation coefficient.

    • ↵a In ratio to internal water for metabolites and in milliseconds for relaxation times.

    • ↵b Values of several ROIs were not sampled for all subjects (n < 60) due to artifacts.

    • ↵c In ratio to the values at 20 years of age.

    • ↵d The values for subjects older than 60 years were not sampled for linear regression.

    • ↵e Variation in 40 years. Significant linear relation of T2′ to age in the pallidum was found for the ages between 20 and 60 years (P < .01), but not for the whole age range (21–70 years, P > .01).

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American Journal of Neuroradiology: 37 (3)
American Journal of Neuroradiology
Vol. 37, Issue 3
1 Mar 2016
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V.V. Eylers, A.A. Maudsley, P. Bronzlik, P.R. Dellani, H. Lanfermann, X.-Q. Ding
Detection of Normal Aging Effects on Human Brain Metabolite Concentrations and Microstructure with Whole-Brain MR Spectroscopic Imaging and Quantitative MR Imaging
American Journal of Neuroradiology Mar 2016, 37 (3) 447-454; DOI: 10.3174/ajnr.A4557

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Detection of Normal Aging Effects on Human Brain Metabolite Concentrations and Microstructure with Whole-Brain MR Spectroscopic Imaging and Quantitative MR Imaging
V.V. Eylers, A.A. Maudsley, P. Bronzlik, P.R. Dellani, H. Lanfermann, X.-Q. Ding
American Journal of Neuroradiology Mar 2016, 37 (3) 447-454; DOI: 10.3174/ajnr.A4557
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