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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleAdult Brain

Favorable Bridging Therapy Based on DWI-FLAIR Mismatch in Patients with Unclear-Onset Stroke

I. Mourand, D. Milhaud, C. Arquizan, K. Lobotesis, R. Schaub, P. Machi, X. Ayrignac, O.F. Eker, A. Bonafé and V. Costalat
American Journal of Neuroradiology January 2016, 37 (1) 88-93; DOI: https://doi.org/10.3174/ajnr.A4574
I. Mourand
aFrom Departments of Neurology (I.M., D.M., C.A., X.A.)
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D. Milhaud
aFrom Departments of Neurology (I.M., D.M., C.A., X.A.)
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C. Arquizan
aFrom Departments of Neurology (I.M., D.M., C.A., X.A.)
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K. Lobotesis
bNeuroradiology (K.L., P.M., O.F.E., A.B., V.C.)
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R. Schaub
cMedical Information (R.S.), University Hospital Center of Montpellier, Gui de Chauliac Hospital, Montpellier, France.
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P. Machi
bNeuroradiology (K.L., P.M., O.F.E., A.B., V.C.)
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X. Ayrignac
aFrom Departments of Neurology (I.M., D.M., C.A., X.A.)
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O.F. Eker
bNeuroradiology (K.L., P.M., O.F.E., A.B., V.C.)
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A. Bonafé
bNeuroradiology (K.L., P.M., O.F.E., A.B., V.C.)
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V. Costalat
bNeuroradiology (K.L., P.M., O.F.E., A.B., V.C.)
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    Fig 1.

    A 49-year-old woman presented with right hemiplegia and dysarthria (NIHSS score, 13). The patient arrived at the emergency department 72 minutes after symptom detection. MR imaging showed an acute ischemic lesion in the left MCA territory on DWI (A and B) without parenchymal signal changes on FLAIR (C and D) and occlusion of the left MCA (M1 segment) with collateral blood flow in the distal cerebral artery territory on MRA (E). Intravenous thrombolysis was started (0.9 mg/kg) 140 minutes after symptom detection. On DSA, the left MCA was still occluded on the M1 segment (F) and was recanalized after mechanical thrombectomy (TICI 3) (G). Time from symptom detection to recanalization was 189 minutes (3 hours 9 minutes). The mRS score at 3 months was zero.

Tables

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  • Predictive factors associated with favorable outcome at day 90 (mRS ≤2)

    VariableBivariate Logistic RegressionMultivariate Logistic Regression
    OR95% CIPOR95% CIP
    Initial NIHSSFor each 1-point decrease1.191.031.37.0171.431.131.82.003
    Treatment groupBridging versus thrombolysis2.950.7212.11.13237.912.43591.35.009
    Blood glucoseFor each 0.5-mmol/L increase0.820.661.02.081
    AgeFor each 5-year increase0.790.601.04.094
    Systolic blood pressureFor each 10-mm Hg increase0.800.591.09.160
    FAT-to-treatment delayFor each 30-minute increase0.810.501.30.377
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American Journal of Neuroradiology: 37 (1)
American Journal of Neuroradiology
Vol. 37, Issue 1
1 Jan 2016
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Cite this article
I. Mourand, D. Milhaud, C. Arquizan, K. Lobotesis, R. Schaub, P. Machi, X. Ayrignac, O.F. Eker, A. Bonafé, V. Costalat
Favorable Bridging Therapy Based on DWI-FLAIR Mismatch in Patients with Unclear-Onset Stroke
American Journal of Neuroradiology Jan 2016, 37 (1) 88-93; DOI: 10.3174/ajnr.A4574

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Favorable Bridging Therapy Based on DWI-FLAIR Mismatch in Patients with Unclear-Onset Stroke
I. Mourand, D. Milhaud, C. Arquizan, K. Lobotesis, R. Schaub, P. Machi, X. Ayrignac, O.F. Eker, A. Bonafé, V. Costalat
American Journal of Neuroradiology Jan 2016, 37 (1) 88-93; DOI: 10.3174/ajnr.A4574
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  • DWI-ASPECTS (Diffusion-Weighted Imaging-Alberta Stroke Program Early Computed Tomography Scores) and DWI-FLAIR (Diffusion-Weighted Imaging-Fluid Attenuated Inversion Recovery) Mismatch in Thrombectomy Candidates: An Intrarater and Interrater Agreement Study
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