Article Figures & Data
Figures
- Fig 1.
A, Representative uncorrected tumor ΔR2* time course and the associated Weisskoff model fit (solid) used to compute K2 at TE1 (square), TE2 (dot), and dual-echo (diamond). B, Corresponding tissue residue functions used to compute Ka at TE1, TE2, and dual-echo.
- Fig 2.
A, T1-weighted post-Gd anatomic image showing a high-grade brain tumor. Sample computed permeability maps (units in minute−1), Ktrans (B), K2 (C), and Ka (D).
- Fig 3.
A, Sample voxelwise comparison between K2 at TE2 and Ktrans. B, Sample voxelwise comparison between Ka at TE2 and Ktrans. C, Voxelwise comparison between K2 (y-axis) and Ka (x-axis). Linear regression line shown in black.
- Fig 4.
Boxplots of median parameter estimates (from all patients) calculated at various TEs for K2 (A) and Ka (B). Boxplots display the median, 25th, and 75th percentiles (edges of box) and extreme data points (whiskers). Outliers are plotted individually (plus sign). Significance was determined by the Mann-Whitney U test. * indicates P < .01; **, P < .001. Note: Positive outlier for K2 at TE1 not pictured.
- Fig 5.
Sample mean ΔR2* time course (TE = 31 ms) for a tumor ROI (A) and the resulting ΔR1 time course (B). Mean ΔR2* (C) and ΔR1 (D) time courses from the same tumor with voxels separated by whether they predominately exhibit T2* leakage effects (T2* voxels) or T1 leakage effects (T1 voxels).
Tables
Patient Age (yr) Sex Prior Resection Pathology OS (mo) 1 61 Female Yes Grade IV glioblastoma 17.9 2 66 Male Yes Grade IV glioblastoma 18.2 3 65 Male Yes Grade III anaplastic astrocytoma NA 4 51 Male Yes Grade IV glioblastoma 4.3 5 55 Male No Grade III oligodendroglioma 13.1 6 40 Male Yes Grade IV glioblastoma 11.0 7 42 Female Yes Grade IV glioblastoma NA Note:—OS indicates overall survival after radiologically confirmed tumor recurrence/progression; NA, not applicable.
- Table 2:
Patient-specific estimates of DSC-MRI and DCE-MRI parameters separated by the predominant leakage effect
Patient No. No. of Voxels (%) K2 (min−1) Ka (min−1) Ktrans (min−1) ve T1 T2* T1 T2* T1 T2* T1 T2* T1 T2* 1 44 (79%) 12 (21%) 1.807 1.205 −0.373 −0.250 0.223 0.066 0.221 0.072 2 214 (45%) 265 (55%) 1.229 −0.815 −0.342 0.026 0.169 0.163 0.359 0.258 3 126 (61%) 79 (39%) 2.374 0.822 −0.372 −0.117 0.089 0.038 0.328 0.150 4 368 (47%) 417 (53%) 1.767 0.700 −0.536 −0.469 0.104 0.078 0.228 0.140 5 187 (56%) 147 (44%) 1.975 0.787 −0.149 −0.025 0.069 0.044 0.284 0.107 6 734 (93%) 52 (7%) 3.726 0.240 −0.256 0.004 0.099 0.050 0.290 0.138 7 16 (64%) 9 (36%) 2.591 0.025 −0.418 0.024 0.200 0.179 0.203 0.107 Meanw 2.627 0.289 −0.329 −0.208 0.109 0.092 0.285 0.167 Note:—Meanw indicates weighted mean.
Jump to section
Related Articles
Cited By...
- Blood-Brain Barrier Permeability and Kinetics of Inflammatory Markers in Acute Stroke Patients Treated With Thrombectomy
- Sex-specific differences in white matter microvascular integrity after ischaemic stroke
- Prognostic Predictions for Patients with Glioblastoma after Standard Treatment: Application of Contrast Leakage Information from DSC-MRI within Nonenhancing FLAIR High-Signal-Intensity Lesions
- Clinical Value of Vascular Permeability Estimates Using Dynamic Susceptibility Contrast MRI: Improved Diagnostic Performance in Distinguishing Hypervascular Primary CNS Lymphoma from Glioblastoma