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Research ArticleAdult Brain

Prognostic Value of Dynamic Susceptibility Contrast-Enhanced and Diffusion-Weighted MR Imaging in Patients with Glioblastomas

G. Çoban, S. Mohan, F. Kural, S. Wang, D.M. O'Rourke and H. Poptani
American Journal of Neuroradiology July 2015, 36 (7) 1247-1252; DOI: https://doi.org/10.3174/ajnr.A4284
G. Çoban
aFrom the Department of Radiology (G.Ç., F.K.), Baskent University School of Medicine, Ankara, Turkey
bDepartments of Radiology (G.Ç., S.M., F.K., S.W., H.P.)
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S. Mohan
bDepartments of Radiology (G.Ç., S.M., F.K., S.W., H.P.)
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F. Kural
aFrom the Department of Radiology (G.Ç., F.K.), Baskent University School of Medicine, Ankara, Turkey
bDepartments of Radiology (G.Ç., S.M., F.K., S.W., H.P.)
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S. Wang
bDepartments of Radiology (G.Ç., S.M., F.K., S.W., H.P.)
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D.M. O'Rourke
cNeurosurgery (D.M.O.), University of Pennsylvania, Philadelphia, Pennsylvania.
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H. Poptani
bDepartments of Radiology (G.Ç., S.M., F.K., S.W., H.P.)
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REFERENCES

  1. 1.↵
    1. Ohgaki H,
    2. Kleihues P
    . Epidemiology and etiology of gliomas. Acta Neuropathol 2005;109:93–108
    CrossRefPubMedWeb of Science
  2. 2.↵
    1. Behin A,
    2. Hoang-Xuan K,
    3. Carpentier AF, et al
    . Primary brain tumours in adults. Lancet 2003;361:323–31
    CrossRefPubMedWeb of Science
  3. 3.↵
    1. Stark AM,
    2. Nabavi A,
    3. Mehdorn HM, et al
    . Glioblastoma multiforme: report of 267 cases treated at a single institution. Surg Neurol 2005;63:162–69
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Kleihues P,
    2. Ohgaki H
    . Primary and secondary glioblastomas: from concept to clinical diagnosis. Neuro Oncol 1999;1:44–51
    Abstract/FREE Full Text
  5. 5.↵
    1. Lacroix M,
    2. Abi-Said D,
    3. Fourney DR, et al
    . A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection of resection and survival. J Neurosurg 2001;95:190–98
    CrossRefPubMedWeb of Science
  6. 6.↵
    1. Mangiola A,
    2. Maira G,
    3. De Bonis P, et al
    . Glioblastoma multiforme in the elderly: a therapeutic challenge. J Neurooncol 2006;76:159–63
    CrossRefPubMed
  7. 7.↵
    1. Galanis E,
    2. Buckner J,
    3. Kimmel D, et al
    . Gene amplification as a prognostic factor in primary and secondary high-grade malignant gliomas. Int J Oncol 1998;13:717–24
    PubMedWeb of Science
  8. 8.↵
    1. Shinojima N,
    2. Tada K,
    3. Shiraishi S, et al
    . Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme. Cancer Res 2003;63:6962–70
    Abstract/FREE Full Text
  9. 9.↵
    1. Law M,
    2. Young RJ,
    3. Babb JS, et al
    . Gliomas: predicting time to progression or survival with cerebral blood volume measurements at dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging. Radiology 2008;247:490–98
    CrossRefPubMedWeb of Science
  10. 10.↵
    1. Spampinato MV,
    2. Schiarelli C,
    3. Cianfoni A, et al
    . Correlation between cerebral blood volume measurements by perfusion-weighted magnetic resonance imaging and two-year progression-free survival in gliomas. Neuroradiol J 2013;26:385–95
    Abstract/FREE Full Text
  11. 11.↵
    1. Bisdas S,
    2. Kirkpatrick M,
    3. Giglio P, et al
    . Cerebral blood volume measurements by perfusion-weighted MR imaging in gliomas: ready for prime time in predicting short-term outcome and recurrent disease? AJNR Am J Neuroradiol 2009;30:681–88
    Abstract/FREE Full Text
  12. 12.↵
    1. Bampoe J,
    2. Bernstein M
    . The role of surgery in low grade gliomas. J Neurooncol 1999;42:259–69
    CrossRefPubMed
  13. 13.↵
    1. Murakami R,
    2. Hirai T,
    3. Sugahara T, et al
    . Grading astrocytic tumors by using apparent diffusion coefficient parameters: superiority of a one versus two-parameter pilot method. Radiology 2009;251:838–45
    CrossRefPubMedWeb of Science
  14. 14.↵
    1. Bode MK,
    2. Ruohonen J,
    3. Nieminen MT, et al
    . Potential of diffusion imaging in brain tumors: a review. Acta Radiol 2006;47:585–94
    FREE Full Text
  15. 15.↵
    1. Murakami R,
    2. Sugahara T,
    3. Nakamura H, et al
    . Malignant supratentorial astrocytoma treated with postoperative radiation therapy: prognostic value of pretreatment quantitative diffusion-weighted MR imaging. Radiology 2007;243:493–99
    CrossRefPubMedWeb of Science
  16. 16.↵
    1. Higano S,
    2. Yun X,
    3. Kumabe T, et al
    . Malignant astrocytic tumors: clinical importance of apparent diffusion coefficient in prediction of grade and prognosis. Radiology 2006;241:839–46
    CrossRefPubMedWeb of Science
  17. 17.↵
    1. Nakamura H,
    2. Murakami R,
    3. Hirai T, et al
    . Can MRI-derived factors predict the survival in glioblastoma patients treated with postoperative chemoradiation therapy? Acta Radiol 2013;54:214–20
    Abstract/FREE Full Text
  18. 18.↵
    1. Oh J,
    2. Henry RG,
    3. Pirzkall A, et al
    . Survival analysis in patients with glioblastoma multiforme: predictive value of choline-to-N-acetylaspartate index, apparent diffusion coefficient, and relative cerebral blood volume. J Magn Reson Imaging 2004;19:546–54
    CrossRefPubMed
  19. 19.↵
    1. Stupp R,
    2. Mason WP,
    3. van den Bent MJ, et al
    . Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005;352:987–96
    CrossRefPubMedWeb of Science
  20. 20.↵
    1. Paul I,
    2. Bhattacharya S,
    3. Chatterjee A, et al
    . Current understanding on EGFR and Wnt/β-catenin signaling in glioma and their possible crosstalk. Genes Cancer 2013;4:427–46
    CrossRefPubMed
  21. 21.↵
    1. Yiin JJ,
    2. Hu B,
    3. Schornack PA, et al
    . ZD6474, a multitargeted inhibitor for receptor tyrosine kinases, suppresses growth of gliomas expressing an epidermal growth factor receptor mutant, EGFRvIII, in the brain. Mol Cancer Ther 2010;9:929–41
    Abstract/FREE Full Text
  22. 22.↵
    1. Johnson G,
    2. Wetzel SG,
    3. Cha S, et al
    . Measuring blood volume and vascular transfer constant from dynamic, T(2)*-weighted contrast-enhanced MRI. Magn Reson Med 2004;51:961–68
    CrossRefPubMed
  23. 23.↵
    1. Knopp EA,
    2. Cha S,
    3. Johnson G, et al
    . Glial neoplasms: dynamic contrast-enhanced T2*-weighted MR imaging. Radiology 1999;211:791–98
    CrossRefPubMedWeb of Science
  24. 24.↵
    1. Rosen BR,
    2. Belliveau JW,
    3. Buchbinder BR, et al
    . Contrast agents and cerebral hemodynamics. Magn Reson Med 1991;19:285–92
    CrossRefPubMedWeb of Science
  25. 25.↵
    1. Rosen BR,
    2. Belliveau JW,
    3. Vevea JM, et al
    . Perfusion imaging with NMR contrast agents. Magn Reson Med 1990;14:249–65
    CrossRefPubMedWeb of Science
  26. 26.↵
    1. Spampinato MV,
    2. Wooten C,
    3. Dorlon M, et al
    . Comparison of first-pass and second-bolus dynamic susceptibility perfusion MRI in brain tumors. Neuroradiology 2006;48:867–74
    CrossRefPubMed
  27. 27.↵
    1. Wetzel SG,
    2. Cha S,
    3. Johnson G, et al
    . Relative cerebral blood volume measurements in intracranial mass lesions: interobserver and intraobserver reproducibility study. Radiology 2002;224:797–803
    CrossRefPubMedWeb of Science
  28. 28.↵
    1. Wang S,
    2. Kim S,
    3. Chawla S, et al
    . Differentiation between glioblastomas, solitary brain metastases, and primary cerebral lymphomas using diffusion tensor and dynamic susceptibility contrast-enhanced MR imaging. AJNR Am J Neuroradiol 2011;32:507–14
    Abstract/FREE Full Text
  29. 29.↵
    1. Lev MH,
    2. Ozsunar Y,
    3. Henson JW, et al
    . Glial tumor grading and outcome prediction using dynamic spin-echo MR susceptibility mapping compared with conventional contrast-enhanced MR: confounding effect of elevated rCBV of oligodendrogliomas. AJNR Am J Neuroradiol 2004;25:214–21
    Abstract/FREE Full Text
  30. 30.↵
    1. Law M,
    2. Oh S,
    3. Babb JS, et al
    . Low-grade gliomas: dynamic susceptibility weighted contrast-enhanced perfusion MR imaging-prediction of patient clinical response. Radiology 2006;238:658–67
    CrossRefPubMedWeb of Science
  31. 31.↵
    1. Law M,
    2. Yang S,
    3. Babb JS, et al
    . Comparison of cerebral blood volume and vascular permeability from dynamic susceptibility contrast-enhanced perfusion MR imaging with glioma grade. AJNR Am J Neuroradiol 2004;25:746–55
    Abstract/FREE Full Text
  32. 32.↵
    1. Mangla R,
    2. Ginat DT,
    3. Kamalian S, et al
    . Correlation between progression free survival and dynamic susceptibility contrast MRI perfusion in WHO grade III glioma subtypes. J Neurooncol 2014;116:325–31
    CrossRefPubMed
  33. 33.↵
    1. Hirai T,
    2. Murakami R,
    3. Nakamura H, et al
    . Prognostic value of perfusion MR imaging of high-grade astrocytomas: long-term follow-up study. AJNR Am J Neuroradiol 2008;29:1505–10
    Abstract/FREE Full Text
  34. 34.↵
    1. Cha S,
    2. Tihan T,
    3. Crawford F, et al
    . Differentiation of low grade oligodendrogliomas from low-grade astrocytomas by using quantitative blood-volume measurements derived from dynamic susceptibility contrast-enhanced MR imaging. AJNR Am J Neuroradiol 2005;26:266–73
    Abstract/FREE Full Text
  35. 35.↵
    1. Essock-Burns E,
    2. Philips JJ,
    3. Molinaro AM, et al
    . Comparison of DSC-MRI post-processing techniques in predicting microvascular histopathology in patients newly diagnosed with GBM. J Magn Reson Imaging 2013;38:388–400
    CrossRefPubMed
  36. 36.↵
    1. Morita N,
    2. Wang S,
    3. Chawla S, et al
    . Dynamic susceptibility contrast perfusion weighted imaging in grading of non-enhancing astrocytomas. J Magn Reson Imaging 2010;32:803–08
    CrossRefPubMed
  37. 37.↵
    1. Wu WC,
    2. Chen CY,
    3. Chung HW, et al
    . Discrepant MR spectroscopic and perfusion imaging results in a case of malignant transformation of cerebral glioma. AJNR Am J Neuroradiol 2002;23:1775–78
    Abstract/FREE Full Text
  38. 38.↵
    1. Nelson SJ
    . Assessment of therapeutic response and treatment planning for brain tumors using metabolic and physiological MRI. NMR Biomed 2011;24:734–49
    PubMedWeb of Science
  39. 39.↵
    1. Yamasaki F,
    2. Sugiyama K,
    3. Ohtaki M, et al
    . Glioblastoma treated with postoperative radiochemotherapy: prognostic value of apparent diffusion coefficient at MR imaging. Eur J Radiol 2010;73:532–37
    CrossRefPubMed
  40. 40.↵
    1. Pierallini A,
    2. Bonamini M,
    3. Pantano P, et al
    . Radiological assessment of necrosis in glioblastoma: variability and prognostic value. Neuroradiology 1998;40:150–53
    CrossRefPubMedWeb of Science
  41. 41.↵
    1. Ru P,
    2. Williams TM,
    3. Chakravarti A, et al
    . Tumor metabolism of malignant gliomas. Cancers 2013;5:1469–84
    CrossRefPubMed
  42. 42.↵
    1. Miyagami M,
    2. Katayama Y
    . Angiogenesis of glioma: evaluation of ultrastructural characteristics of microvessels and tubular bodies (Weibel-Palade) in endothelial cells and immunohistochemical findings with VEGF and p53 protein. Med Mol Morphol 2005;38:36–42
    CrossRefPubMed
  43. 43.↵
    1. Kapoor GS,
    2. Gocke TA,
    3. Chawla S, et al
    . Magnetic resonance perfusion weighted imaging defines angiogenic subtypes of oligodendroglioma according to1p19q and EGFR status. J Neurooncol 2009;92:373–86
    CrossRefPubMed
  44. 44.↵
    1. Abdulrauf SI,
    2. Edvardsen K,
    3. Ho KL, et al
    . Vascular endothelial growth factor expression and vascular density as prognostic markers of survival in patients with low-grade astrocytoma. J Neurosurg 1998;88:513–20
    CrossRefPubMedWeb of Science
  45. 45.↵
    1. Shaw EG,
    2. Tatter SB,
    3. Lesser GJ, et al
    . Current controversies in the radiotherapeutic management of adult low-grade glioma. Semin Oncol 2004;31:653–58
    CrossRefPubMed
  46. 46.↵
    1. Stupp R,
    2. Baumert BG
    . Promises and controversies in the management of low-grade glioma. Ann Oncol 2003;14:1695–96
    FREE Full Text
  47. 47.↵
    1. Xie K,
    2. Yang J,
    3. Zhang ZG, et al
    . Semi-automated brain tumor and edema segmentation using MRI. Eur J Radiol 2005;56:12–19
    CrossRefPubMed
  48. 48.↵
    1. Kaus MR,
    2. Warfield SK,
    3. Nabavi A, et al
    . Automated segmentation of MR images of brain tumors. Radiology 2001;218:586–91
    CrossRefPubMedWeb of Science
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G. Çoban, S. Mohan, F. Kural, S. Wang, D.M. O'Rourke, H. Poptani
Prognostic Value of Dynamic Susceptibility Contrast-Enhanced and Diffusion-Weighted MR Imaging in Patients with Glioblastomas
American Journal of Neuroradiology Jul 2015, 36 (7) 1247-1252; DOI: 10.3174/ajnr.A4284

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Prognostic Value of Dynamic Susceptibility Contrast-Enhanced and Diffusion-Weighted MR Imaging in Patients with Glioblastomas
G. Çoban, S. Mohan, F. Kural, S. Wang, D.M. O'Rourke, H. Poptani
American Journal of Neuroradiology Jul 2015, 36 (7) 1247-1252; DOI: 10.3174/ajnr.A4284
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