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Acquisition Parameter Recommendation Pulse sequence Generally GRE-EPI rather than SE-EPI TR 1.0–1.5 seconds (SE-EPI); minimum (vs “as short as possible”) for GRE-EPI; generally 1.0–1.5 seconds TE 40–45 ms at 1.5T; 25–35 ms at 3T Flip angle 60°–70° Temporal coverage 120 Time points Preload Gd-based contrast agent dose (particularly for studies performed with a high flip angle) One-fourth to single dose (0.025–0.1 mmol/kg Gd), given 5–10 minutes prior to dynamic imaging Slice thickness 3–5 mm Matrix 128 × 128 (range, 64 × 64 to 256 × 256) FOV 20 × 20 cm (range, 20 × 20 to 24 × 24 cm) IV catheter gauge 18- to 20-ga antecubital IV, right arm preferred Injection rate 3–5 mL/s Total acquisition time Approximately 2 minutes Note:—Gd indicates gadolinium.
CBV MTT TTP Tmax CBF DWI Ischemic core ↓ ↑↑ ↑↑ ↑↑ ↓↓ Restricted Ischemic penumbra ↔↑ ↑ ↑ ↑ ↓ Nonrestricted Note:—↓ indicates decreased; ↑, increased; ↑↑, largely increased; ↓↓, largely decreased; ↔↑, unchanged or increased.
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