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Research ArticleBrain
Open Access

Fast Contrast-Enhanced 4D MRA and 4D Flow MRI Using Constrained Reconstruction (HYPRFlow): Potential Applications for Brain Arteriovenous Malformations

W. Chang, Y. Wu, K. Johnson, M. Loecher, O. Wieben, M. Edjlali, C. Oppenheim, P. Roca, J. Hald, B. Aagaard-Kienitz, D. Niemann, C. Mistretta and P. Turski
American Journal of Neuroradiology June 2015, 36 (6) 1049-1055; DOI: https://doi.org/10.3174/ajnr.A4245
W. Chang
aFrom the Department of Radiology (W.C.), University of California, Los Angeles, Los Angeles, California
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Y. Wu
dMedical Physics (Y.W., K.J., M.L., O.W., C.M.), University of Wisconsin School of Medicine, Madison, Wisconsin
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K. Johnson
dMedical Physics (Y.W., K.J., M.L., O.W., C.M.), University of Wisconsin School of Medicine, Madison, Wisconsin
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M. Loecher
dMedical Physics (Y.W., K.J., M.L., O.W., C.M.), University of Wisconsin School of Medicine, Madison, Wisconsin
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O. Wieben
dMedical Physics (Y.W., K.J., M.L., O.W., C.M.), University of Wisconsin School of Medicine, Madison, Wisconsin
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M. Edjlali
eDepartment of Radiology (M.E., C.O., P.R.), Université Paris-Descartes, Paris, France
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C. Oppenheim
eDepartment of Radiology (M.E., C.O., P.R.), Université Paris-Descartes, Paris, France
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P. Roca
eDepartment of Radiology (M.E., C.O., P.R.), Université Paris-Descartes, Paris, France
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J. Hald
fDepartment of Radiology (J.H.), Rikshospitalet, Oslo, Norway.
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B. Aagaard-Kienitz
bDepartments of Radiology (B.A.-K., P.T.)
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D. Niemann
cNeurosurgery (D.N.)
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C. Mistretta
dMedical Physics (Y.W., K.J., M.L., O.W., C.M.), University of Wisconsin School of Medicine, Madison, Wisconsin
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P. Turski
bDepartments of Radiology (B.A.-K., P.T.)
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    Fig 1.

    HYPRFlow image reconstruction. Top row: 60 whole-brain 3D radial scans are obtained every 0.5 seconds and reconstructed by using a 0.75-second acquisition window during the first passage of the contrast bolus. Four scans are displayed from this time-series (3D CE-VIPR timeframes). Top right: following the dynamic scan, a 3D radial phase-contrast MRA is obtained (5-minute PC-VIPR MRA used as the vascular constraint). Middle row: temporal weighting images are produced by using a low-pass filter. Bottom row: HYPR LR multiplication and reconstruction are performed by using the phase-contrast angiographic data to constrain the dynamic weighting images. Four HYPRFlow images from the 60-image time-series are displayed, demonstrating improved SNR and spatial resolution following HYPR LR reconstruction.

  • Fig 2.
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    Fig 2.

    Right temporal lobe AVM. Top row: 3 HYPRFlow images from the 60-image dynamic series. Arterial (A), mixed (B), and venous phase (C) images are displayed. Bottom row: corresponding DSA arterial (D), mixed (E), and venous phase (F) images. The HYPRFlow images demonstrate the cortical venous drainage similar to the DSA.

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    Fig 3.

    HYPRFlow images of a left parietal occipital AVM, demonstrating whole-brain coverage and isotropic 0.68-mm resolution. Top row: axial HYPRFlow MIP images left to right: arterial, mixed, and venous phase. Bottom row: the same image data projected into the coronal plane, left to right: arterial, mixed, and venous phase images.

  • Fig 4.
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    Fig 4.

    The same patient as shown in Fig 3. Top row: HYPRFlow images in the sagittal plane: arterial (A), mixed (B), and venous phase (C). Bottom row: corresponding DSA images: arterial (D), mixed (E), and venous phase (F). Note the excellent correlation of the arterial supply and venous drainage pattern.

  • Fig 5.
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    Fig 5.

    Left posterior frontal AVM. A, The DSA examination demonstrates a small deep medullary vein (arrows), which drains into the straight sinus. The AVM nidus was in close proximity to the Broca area and was scored as Spetzler-Martin grade III. B, Coronal HYPRFlow late arterial phase image with poor delineation of the deep medullary vein (arrows), resulting in incorrect classification of the AVM as Spetzler-Martin grade II.

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American Journal of Neuroradiology: 36 (6)
American Journal of Neuroradiology
Vol. 36, Issue 6
1 Jun 2015
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W. Chang, Y. Wu, K. Johnson, M. Loecher, O. Wieben, M. Edjlali, C. Oppenheim, P. Roca, J. Hald, B. Aagaard-Kienitz, D. Niemann, C. Mistretta, P. Turski
Fast Contrast-Enhanced 4D MRA and 4D Flow MRI Using Constrained Reconstruction (HYPRFlow): Potential Applications for Brain Arteriovenous Malformations
American Journal of Neuroradiology Jun 2015, 36 (6) 1049-1055; DOI: 10.3174/ajnr.A4245

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Fast Contrast-Enhanced 4D MRA and 4D Flow MRI Using Constrained Reconstruction (HYPRFlow): Potential Applications for Brain Arteriovenous Malformations
W. Chang, Y. Wu, K. Johnson, M. Loecher, O. Wieben, M. Edjlali, C. Oppenheim, P. Roca, J. Hald, B. Aagaard-Kienitz, D. Niemann, C. Mistretta, P. Turski
American Journal of Neuroradiology Jun 2015, 36 (6) 1049-1055; DOI: 10.3174/ajnr.A4245
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