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Research ArticleBrain
Open Access

Modeling the Relationship among Gray Matter Atrophy, Abnormalities in Connecting White Matter, and Cognitive Performance in Early Multiple Sclerosis

A.F. Kuceyeski, W. Vargas, M. Dayan, E. Monohan, C. Blackwell, A. Raj, K. Fujimoto and S.A. Gauthier
American Journal of Neuroradiology April 2015, 36 (4) 702-709; DOI: https://doi.org/10.3174/ajnr.A4165
A.F. Kuceyeski
aFrom the Departments of Radiology (A.F.K., M.D., A.R.)
cThe Brain and Mind Research Institute (A.F.K., A.R., S.A.G.), Weill Cornell Medical College, New York, New York.
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W. Vargas
bNeurology (W.V., E.M., C.B., K.F., S.A.G.)
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M. Dayan
aFrom the Departments of Radiology (A.F.K., M.D., A.R.)
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E. Monohan
bNeurology (W.V., E.M., C.B., K.F., S.A.G.)
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C. Blackwell
bNeurology (W.V., E.M., C.B., K.F., S.A.G.)
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A. Raj
aFrom the Departments of Radiology (A.F.K., M.D., A.R.)
cThe Brain and Mind Research Institute (A.F.K., A.R., S.A.G.), Weill Cornell Medical College, New York, New York.
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K. Fujimoto
bNeurology (W.V., E.M., C.B., K.F., S.A.G.)
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S.A. Gauthier
bNeurology (W.V., E.M., C.B., K.F., S.A.G.)
cThe Brain and Mind Research Institute (A.F.K., A.R., S.A.G.), Weill Cornell Medical College, New York, New York.
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REFERENCES

  1. 1.↵
    1. Pagani E,
    2. Bammer R,
    3. Horsfield MA, et al
    . Diffusion MR imaging in multiple sclerosis: technical aspects and challenges. AJNR Am J Neuroradiol 2007;28:411–20
    Abstract/FREE Full Text
  2. 2.↵
    1. Gorgoraptis N,
    2. Wheeler-Kingshott CA,
    3. Jenkins TM, et al
    . Combining tractography and cortical measures to test system-specific hypotheses in multiple sclerosis. Mult Scler 2010;16:555–65
    Abstract/FREE Full Text
  3. 3.↵
    1. Rovaris M,
    2. Filippi M,
    3. Minicucci L, et al
    . Cortical/subcortical disease burden and cognitive impairment in patients with multiple sclerosis. AJNR Am J Neuroradiol 2000;21:402–08
    Abstract/FREE Full Text
  4. 4.↵
    1. Geurts JJ,
    2. Barkhof F
    . Grey matter pathology in multiple sclerosis. Lancet Neurol 2008;7:841–51
    CrossRefPubMedWeb of Science
  5. 5.↵
    1. Calabrese M,
    2. Romualdi C,
    3. Poretto V, et al
    . The changing clinical course of multiple sclerosis: a matter of grey matter. Ann Neurol 2013;74:76–83
    CrossRefPubMed
  6. 6.↵
    1. Geurts JJ,
    2. Stys PK,
    3. Minagar A, et al
    . Gray matter pathology in (chronic) MS: modern views on an early observation. J Neurol Sci 2009;282:12–20
    CrossRefPubMedWeb of Science
  7. 7.↵
    1. Narayanan S,
    2. Fu L,
    3. Pioro E, et al
    . Imaging of axonal damage in multiple sclerosis: spatial distribution of magnetic resonance imaging lesions. Ann Neurol 1997;41:385–91
    CrossRefPubMedWeb of Science
  8. 8.↵
    1. Shu N,
    2. Liu Y,
    3. Li K, et al
    . Diffusion tensor tractography reveals disrupted topological efficiency in white matter structural networks in multiple sclerosis. Cereb Cortex 2011;21:2565–77
    Abstract/FREE Full Text
  9. 9.↵
    1. Rocca MA,
    2. Valsasina P,
    3. Martinelli V, et al
    . Large-scale neuronal network dysfunction in relapsing-remitting multiple sclerosis. Neurology 2012;79:1449–57
    CrossRefPubMed
  10. 10.↵
    1. Bodini B,
    2. Khaleeli Z,
    3. Cercignani M, et al
    . Exploring the relationship between white matter and gray matter damage in early primary progressive multiple sclerosis: an in vivo study with TBSS and VBM. Hum Brain Mapp 2009;30:2852–61
    CrossRefPubMedWeb of Science
  11. 11.↵
    1. Sbardella E,
    2. Petsas N,
    3. Tona F, et al
    . Assessing the correlation between grey and white matter damage with motor and cognitive impairment in multiple sclerosis patients. PLoS One 2013;8:e63250
    CrossRefPubMed
  12. 12.↵
    1. Raj A,
    2. Kuceyeski A,
    3. Weiner M
    . A network diffusion model of disease progression in dementia. Neuron 2012;73:1204–15
    CrossRefPubMedWeb of Science
  13. 13.↵
    1. Zhou J,
    2. Gennatas ED,
    3. Kramer JH, et al
    . Predicting regional neurodegeneration from the healthy brain functional connectome. Neuron 2012;73:1216–27
    CrossRefPubMedWeb of Science
  14. 14.↵
    1. Mesaros S,
    2. Rocca MA,
    3. Kacar K, et al
    . Diffusion tensor MRI tractography and cognitive impairment in multiple sclerosis. Neurology 2012;78:969–75
    CrossRefPubMed
  15. 15.↵
    1. Hu B,
    2. Ye B,
    3. Yang Y, et al
    . Quantitative diffusion tensor deterministic and probabilistic fiber tractography in relapsing-remitting multiple sclerosis. Eur J Radiol 2011;79:101–07
    CrossRefPubMed
  16. 16.↵
    1. Jones DK,
    2. Cercignani M
    . Twenty-five pitfalls in the analysis of diffusion MRI data. NMR Biomed 2010;23:803–20
    CrossRefPubMedWeb of Science
  17. 17.↵
    1. Pierpaoli C,
    2. Barnett A,
    3. Pajevic S, et al
    . Water diffusion changes in Wallerian degeneration and their dependence on white matter architecture. Neuroimage 2001;13(6 pt 1):1174–85
    PubMedWeb of Science
  18. 18.↵
    1. Wheeler-Kingshott CA,
    2. Cercignani M
    . About “axial” and “radial” diffusivities. Magn Reson Med 2009;61:1255–60
    CrossRefPubMedWeb of Science
  19. 19.↵
    1. Kuceyeski A,
    2. Maruta J,
    3. Relkin N, et al
    . The Network Modification (NeMo) Tool: elucidating the effect of white matter integrity changes on cortical and subcortical structural connectivity. Brain Connect 2013;3:451–63
    CrossRefPubMed
  20. 20.↵
    1. Krishnan A,
    2. Williams LJ,
    3. McIntosh AR, et al
    . Partial least squares (PLS) methods for neuroimaging: a tutorial and review. Neuroimage 2011;56:455–75
    CrossRefPubMedWeb of Science
  21. 21.↵
    1. Bergendal G,
    2. Fredrikson S,
    3. Almkvist O
    . Selective decline in information processing in subgroups of multiple sclerosis: an 8-year longitudinal study. Eur Neurol 2007;57:193–202
    CrossRefPubMedWeb of Science
  22. 22.↵
    1. Fischl B,
    2. Sereno MI,
    3. Dale AM
    . Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. Neuroimage 1999;9:195–207
    CrossRefPubMedWeb of Science
  23. 23.↵
    1. Penny WD,
    2. Friston KJ,
    3. Ashburner JT, et al.
    , eds. Statistical Parametric Mapping: The Analysis of Functional Brain Images. Burlington: Academic Press; 2006:656
  24. 24.↵
    1. Smith SM
    . Fast robust automated brain extraction. Hum Brain Mapp 2002;17:143–55
    CrossRefPubMedWeb of Science
  25. 25.↵
    1. Crawford JR,
    2. Garthwaite PH,
    3. Ryan K
    . Comparing a single case to a control sample: testing for neuropsychological deficits and dissociations in the presence of covariates. Cortex 2011;47:1166–78
    CrossRefPubMed
  26. 26.↵
    1. Benjamini Y,
    2. Hochberg Y
    . Controlling the false discovery rate: a practical and powerful approach to multiple testing. Journal of the Royal Statistical Society 1995;57:289–300
    CrossRefWeb of Science
  27. 27.↵
    1. Wold S,
    2. Sjöström M,
    3. Eriksson L
    . PLS-regression: a basic tool of chemometrics. Chemometrics and Intelligent Laboratory System 2001;58:109–30
    CrossRef
  28. 28.↵
    1. Efron B,
    2. Tibshirani R
    . An Introduction to the Bootstrap. London: Chapman and Hall/CRC; 1994:456
  29. 29.↵
    1. Šidák Z
    . Rectangular confidence regions for the means of multivariate normal distributions. J Amer Statist Assn 1967;62:626–33
  30. 30.↵
    1. Centofani CC
    . Selected Somatosensory and Cognitive Test Performances as a Function of Age and Education in Normal and Neurologically Impaired Adults [dissertation]. Ann Arbor: University of Michigan; 1975
  31. 31.↵
    1. Bate AJ,
    2. Mathias JL,
    3. Crawford JR
    . Performance on the Test of Everyday Attention and standard tests of attention following severe traumatic brain injury. Clin Neuropsychol 2001;15:405–22
    CrossRefPubMed
  32. 32.↵
    1. Karpuk N,
    2. Burkovetskaya M,
    3. Kielian T
    . Neuroinflammation alters voltage-dependent conductance in striatal astrocytes. J Neurophysiol 2012;108:112–23
    Abstract/FREE Full Text
  33. 33.↵
    1. Cappellani R,
    2. Bergsland N,
    3. Weinstock-Guttman B, et al
    . Subcortical deep gray matter pathology in patients with multiple sclerosis is associated with white matter lesion burden and atrophy but not with cortical atrophy: a diffusion tensor MRI study. AJNR Am J Neuroradiol 2014;35:912–19
    Abstract/FREE Full Text
  34. 34.↵
    1. Tao G,
    2. Datta S,
    3. He R, et al
    . Deep gray matter atrophy in multiple sclerosis: a tensor based morphometry. J Neurol Sci 2009;282:39–46
    CrossRefPubMedWeb of Science
  35. 35.↵
    1. Henry RG,
    2. Shieh M,
    3. Amirbekian B, et al
    . Connecting white matter injury and thalamic atrophy in clinically isolated syndromes. J Neurol Sci 2009;282:61–66
    CrossRefPubMedWeb of Science
  36. 36.↵
    1. Mühlau M,
    2. Buck D,
    3. Förschler A, et al
    . White-matter lesions drive deep gray-matter atrophy in early multiple sclerosis: support from structural MRI. Mult Scler 2013;19:1485–92
    Abstract/FREE Full Text
  37. 37.↵
    1. Dineen RA,
    2. Vilisaar J,
    3. Hlinka J, et al
    . Disconnection as a mechanism for cognitive dysfunction in multiple sclerosis. Brain 2009;132(pt 1):239–49
    Abstract/FREE Full Text
  38. 38.↵
    1. Roosendaal SD,
    2. Geurts JJ,
    3. Vrenken H, et al
    . Regional DTI differences in multiple sclerosis patients. Neuroimage 2009;44:1397–403
    CrossRefPubMedWeb of Science
  39. 39.↵
    1. Lucchinetti CF,
    2. Popescu BFG,
    3. Bunyan RF, et al
    . Inflammatory cortical demyelination in early multiple sclerosis. N Engl J Med 2011;365:2188–97
    CrossRefPubMedWeb of Science
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A.F. Kuceyeski, W. Vargas, M. Dayan, E. Monohan, C. Blackwell, A. Raj, K. Fujimoto, S.A. Gauthier
Modeling the Relationship among Gray Matter Atrophy, Abnormalities in Connecting White Matter, and Cognitive Performance in Early Multiple Sclerosis
American Journal of Neuroradiology Apr 2015, 36 (4) 702-709; DOI: 10.3174/ajnr.A4165

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Modeling the Relationship among Gray Matter Atrophy, Abnormalities in Connecting White Matter, and Cognitive Performance in Early Multiple Sclerosis
A.F. Kuceyeski, W. Vargas, M. Dayan, E. Monohan, C. Blackwell, A. Raj, K. Fujimoto, S.A. Gauthier
American Journal of Neuroradiology Apr 2015, 36 (4) 702-709; DOI: 10.3174/ajnr.A4165
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