Comparing 3T and 1.5T MRI for Mapping Hippocampal Atrophy in the Alzheimer's Disease Neuroimaging Initiative

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Fig 1.
3D statistical maps of diagnostic comparisons by using 1.5T and 3T. Red and white areas in the significance maps correspond to P < .05.
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Fig 2.
3D statistical maps for MCI converters versus nonconverters at 1.5T and 3T.
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Fig 3.
Receiver operator characteristic curves of the ability of mean CA1 radial distance to differentiate between MCI converters versus nonconverters at 1.5T and 3T. AUC indicates area under the curve.

Demographic characteristics for the diagnostic-comparisons study

Variable	NC (n = 53)^{^a}	MCI (n = 76)^{^a}	AD (n = 37)^{^a}	P Value
Age (yr)	75.4 ± 4.7 (60–87)	75.2 ± 8.2 (55–88)	74.1 ± 8.7 (57–91)	.671
Education (yr)	16.1 ± 2.8 (7–20)	15.9 ± 3.2 (6–20)	14.6 ± 3.2 (7–20)	.055
Sex, M/F	18:35	47:29	13:24	.002^{^b}
MMSE	29.3 ± 0.9 (26–30)	26.8 ± 1.9 (23–30)	23.3 ± 2.1 (20–27)	<.0001^{^b}
CDR global	0 ± 0 (0)	0.50 ± 0 (1)	0.69 ± 0.25 (1)	<.0001^{^b}
CDR sum of boxes	1.0 ± 0.2 (1–2)	2.8 ± 1.0 (2–6)	5.1 ± 1.5 (3–9)	<.0001^{^b}
1.5T Left hippocampus (mm³)	3859 ± 436 (2707–4730)	3335 ± 588 (1730–4827)	3242 ± 615 (1573–4302)	<.0001^{^b}
1.5T Right hippocampus (mm³)	3734 ± 591 (2114–5441)	3254 ± 641 (850–4796)	3110 ± 668 (613–4814)	<.0001^{^b}
3T Left hippocampus (mm³)	3897 ± 758 (408–5087)	3259 ± 601 (1627–4697)	3123 ± 598 (2013–4437)	<.0001^{^b}
3T Right hippocampus (mm³)	3981 ± 612 (1468–5158)	3389 ± 638 (1800–5053)	3237 ± 672 (1873–4577)	<.0001^{^b}