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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticlePediatric Neuroimaging

Pleomorphic Xanthoastrocytoma of Childhood: MR Imaging and Diffusion MR Imaging Features

W. Moore, D. Mathis, L. Gargan, D.C. Bowers, L.J. Klesse, L. Margraf and K. Koral
American Journal of Neuroradiology November 2014, 35 (11) 2192-2196; DOI: https://doi.org/10.3174/ajnr.A4011
W. Moore
aFrom the Departments of Radiology (W.M., K.K.)
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D. Mathis
bPathology (D.M., L.M.)
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L. Gargan
gNeuro-Oncology (L.G.), Children's Medical Center, Dallas, Texas.
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D.C. Bowers
cPediatrics (D.C.B., L.J.K.), University of Texas Southwestern Medical Center, Dallas, Texas
fPediatrics (D.C.B., L.J.K.)
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L.J. Klesse
cPediatrics (D.C.B., L.J.K.), University of Texas Southwestern Medical Center, Dallas, Texas
fPediatrics (D.C.B., L.J.K.)
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L. Margraf
bPathology (D.M., L.M.)
ePathology (L.M.)
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K. Koral
aFrom the Departments of Radiology (W.M., K.K.)
dDepartments of Radiology (K.K.)
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    Fig 1.

    Right frontal PXA in a 4.5-year-old girl (patient number 5). A, Sagittal T1-weighted image shows multiple cystic components with hyperintense fluid within a cyst. The crescentic hyperintense fluid corresponds to blood on CT, HU = +77 (B). C, Coronal T2-weighted image shows the lateral solid components and focal scalloping of the overlying inner table (arrows). D, Axial FLAIR image shows marked vasogenic edema. E, Gadolinium-enhanced coronal T1-weighted image shows intense enhancement of the lateral solid components. F and G, Axial diffusion-weighted image and ADC map show that the solid component shows reduced diffusion compared with normal brain (ADC ratio = 0.85).

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    Fig 2.

    Left frontal PXA in a 4.8-year-old boy (patient number 2). A, Preoperative axial FLAIR image shows marked vasogenic edema. B, Preoperative coronal T1-weighted gadolinium-enhanced image shows intense enhancement of the lesion. C, The calculated preoperative ADC ratio was 1.06. D, The mass could not be resected completely because of its proximity to the left middle cerebral artery and showed progression over 4 years. Sagittal gadolinium-enhanced T1-weighted image shows the signal void of a middle cerebral artery branch within the enhancing mass.

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    Fig 3.

    Left frontal and parietal PXA with anaplastic features in a 6.1-year-old male (patient number 8). A, Preoperative axial gadolinium-enhanced T1-weighted image shows a predominantly cystic mass with marked vasogenic edema. B, ADC ratio of the tissue corresponding to the solid enhancing tumor is 0.75.

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  • Individual patient information on demographics, histology, treatment, and outcome

    Patient No.Age (y)/SexDiagnosisADC Value (×10−6 mm2/s)ADC RatioTreatmentF/U (y)Treatment ResponseTTP (y)F/U Results
    14.7/FPXAXRT/Chemo14.8PD8.6Alive
    24.8/MPXA8381.06Sx (3)/XRT5.0PD2.7Alive
    37.1/FAnap. PXASx (2)/XRT/Chemo0.5PD0.2Died
    49.3/FPXA9281.24Sx7.7CRn/aAlive
    54.5/FPXA6680.85SxLost to F/U
    66.9/MPXA11891.47Sx (3)9.6PD3.8Alive
    716.1/MPXA8891.28Sx3.4CRn/aAlive
    86.1/MAnap. PXA8250.75Sx/XRT/Chemo4.0CRn/aAlive
    911.6/MPXA7621.32SxLost to F/U
    1014.0/FPXASx/XRT/Chemo8.2PD0.8Died
    1113.0/MAnap. PXASx/XRT/Chemo2.5CRn/aAlive
    • Note:—Anap. indicates anaplastic; Chemo, chemotherapy; CR, complete remission; F/U, follow-up; PD, progressive disease; Sx, surgery; XRT, radiotherapy.

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American Journal of Neuroradiology: 35 (11)
American Journal of Neuroradiology
Vol. 35, Issue 11
1 Nov 2014
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Cite this article
W. Moore, D. Mathis, L. Gargan, D.C. Bowers, L.J. Klesse, L. Margraf, K. Koral
Pleomorphic Xanthoastrocytoma of Childhood: MR Imaging and Diffusion MR Imaging Features
American Journal of Neuroradiology Nov 2014, 35 (11) 2192-2196; DOI: 10.3174/ajnr.A4011

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Pleomorphic Xanthoastrocytoma of Childhood: MR Imaging and Diffusion MR Imaging Features
W. Moore, D. Mathis, L. Gargan, D.C. Bowers, L.J. Klesse, L. Margraf, K. Koral
American Journal of Neuroradiology Nov 2014, 35 (11) 2192-2196; DOI: 10.3174/ajnr.A4011
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  • MR Imaging Features of Anaplastic Pleomorphic Xanthoastrocytoma Mimicking High-Grade Astrocytoma
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