Magnetization Transfer Imaging in Premanifest and Manifest Huntington Disease: A 2-Year Follow-Up

S.J.A. van den Bogaard; E.M. Dumas; E.P. Hart; J. Milles; R. Reilmann; J.C. Stout; D. Craufurd; C.R. Gibbard; S.J. Tabrizi; M.A. van Buchem; J. van der Grond; R.A.C. Roos

doi:10.3174/ajnr.A3303

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Research ArticleBrain

Magnetization Transfer Imaging in Premanifest and Manifest Huntington Disease: A 2-Year Follow-Up

S.J.A. van den Bogaard, E.M. Dumas, E.P. Hart, J. Milles, R. Reilmann, J.C. Stout, D. Craufurd, C.R. Gibbard, S.J. Tabrizi, M.A. van Buchem, J. van der Grond and R.A.C. Roos

American Journal of Neuroradiology February 2013, 34 (2) 317-322; DOI: https://doi.org/10.3174/ajnr.A3303

S.J.A. van den Bogaard

aFrom the Department of Neurology (S.J.A.v.d.B., E.M.D., E.P.H., R.A.C.R.)

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E.M. Dumas

aFrom the Department of Neurology (S.J.A.v.d.B., E.M.D., E.P.H., R.A.C.R.)

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E.P. Hart

aFrom the Department of Neurology (S.J.A.v.d.B., E.M.D., E.P.H., R.A.C.R.)

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J. Milles

bDivision of Image Processing, Department of Radiology (J.M.)

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R. Reilmann

dDepartment of Neurology (R.R.), University of Munster, Munster, Germany

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J.C. Stout

eSchool of Psychology and Psychiatry (J.C.S.), Monash University, Victoria, Australia

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D. Craufurd

fManchester Academic Health Sciences Centre and Central Manchester University Hospitals NHS Foundation Trust (D.C.), University of Manchester, Manchester, UK

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C.R. Gibbard

gDepartment of Neurology (C.R.G., S.J.T.), Institute of Neurology, University College London, London, UK.

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S.J. Tabrizi

gDepartment of Neurology (C.R.G., S.J.T.), Institute of Neurology, University College London, London, UK.

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M.A. van Buchem

cDepartment of Radiology (M.A.v.B., J.v.d.G.), Leiden University Medical Center, Leiden, the Netherlands

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J. van der Grond

cDepartment of Radiology (M.A.v.B., J.v.d.G.), Leiden University Medical Center, Leiden, the Netherlands

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R.A.C. Roos

aFrom the Department of Neurology (S.J.A.v.d.B., E.M.D., E.P.H., R.A.C.R.)

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Online Appendix and Tables (PDF) -

Online Appendix: see file

Online Table 1: MTI-derived values in 14 different regions on both baseline and follow-up visit for the premanifest HD A and premanifest HD B group

Online Table 2: MTI-derived values in 14 different regions on both baseline and follow-up visit for the manifest HD 1 and manifest HD 2 group

Online Table 3: Volumetric analysis of 14 brain regions in premanifest HD

Online Table 4: Volumetric analysis of 14 brain regions in manifest HD

Online Table 5: Control values of MTR parameters

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S.J.A. van den Bogaard, E.M. Dumas, E.P. Hart, J. Milles, R. Reilmann, J.C. Stout, D. Craufurd, C.R. Gibbard, S.J. Tabrizi, M.A. van Buchem, J. van der Grond, R.A.C. Roos

Magnetization Transfer Imaging in Premanifest and Manifest Huntington Disease: A 2-Year Follow-Up

American Journal of Neuroradiology Feb 2013, 34 (2) 317-322; DOI: 10.3174/ajnr.A3303

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Magnetization Transfer Imaging in Premanifest and Manifest Huntington Disease: A 2-Year Follow-Up

S.J.A. van den Bogaard, E.M. Dumas, E.P. Hart, J. Milles, R. Reilmann, J.C. Stout, D. Craufurd, C.R. Gibbard, S.J. Tabrizi, M.A. van Buchem, J. van der Grond, R.A.C. Roos

American Journal of Neuroradiology Feb 2013, 34 (2) 317-322; DOI: 10.3174/ajnr.A3303

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