Magnetization Transfer Imaging in Premanifest and Manifest Huntington Disease: A 2-Year Follow-Up

Article Figures & Data

Group characteristics for controls, premanifest HD groups A + B, and manifest HD groups 1 and 2^{^a}

		Controls	Premanifest A	Premanifest B	Manifest 1	Manifest 2
No.		25	10	11	9	12
Age	Baseline	48.3 (7.6)	45.5 (5.2)	42.9 (11.2)	47.7 (11.8)	50.9 (9.4)
CAG	Baseline	Baseline	41.3 (1.3)	44.0 (3.1)	43.8 (3.5)	43.2 (1.9)
YTO	Baseline	Baseline	13.8 (3.8)	8.4 (1.6)	N/A	N/A
TMS	Baseline	Baseline	2.3 (1.7)	3.0 (1.1)	16.9 (8.8)	26.2 (11.7)
TMS	Follow-up	1.7 (1.4)	6.0 (6.9)	6.3 (2.5)^{^b}	23.0 (9.0)^{^b}	37.8 (14.3)^{^b}
TFC	Baseline	12.9 (0.2)	12.7 (0.7)	12.6 (0.9)	12.0 (1.0)	8.6 (1.2)
TFC	Follow-up	12.8 (	12.5 (0.9)	12.4 (1.2)	11.2 (2.0)	6.0 (3.3)^{^b}
MMSE	Baseline	29.2 (1.2)	29.0 (1.2)	28.4 (1.9)	29.0 (0.9)	26.5 (3.1)
MMSE	Follow-up	29.1 (1.2)	29.3 (0.8)	28.6 (1.7)	28.7 (1.1)	27.0 (3.9)
SDMT	Baseline	50.1 (9.6)	52.7 (7.4)	46.9 (12.0)	42.0 (8.1)	31.2 (11.1)
SDMT	Follow-up	51.5 (10.8)	52.7 (9.5)	48.3 (9.9)	39.6 (10.7)	27.9 (13.3)
Stroop	Baseline	99.8 (13.4)	97.1 (10.5)	86.9 (16.3)	88.4 (13.6)	69.4 (21.5)
Stroop	Follow-up	102.7 (16.9)	92.5 (7.5)	83.4 (19.3)	89.8 (18.9)	55.6 (22.6)^{^b}
PBA	Baseline	6.4 (8.4)	6.7 (8.7)	7.4 (7.1)	11.7 (11.7)	14.0 (11.8)
PBA	Follow-up	6.6 (9.0)	6.1 (11.9)	7.8 (9.70	9.7 (11.7)	22.6 (16.3)

Note:—CAG indicates cytosine-adenosine-guanine–repeat length; YTO, expected years to disease onset; TMS, total motor score; TFC, total functional capacity; MMSE, Mini-Mental State Examination; SDMT, Symbol-Digit Modality Test; PBA, Problem Behavior Assessment; N/A = not applicable.
↵a Values are mean (SD).
↵b P < .005 significant longitudinal change.