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Research ArticleBrainF

Does MR Perfusion Imaging Impact Management Decisions for Patients with Brain Tumors? A Prospective Study

C.P. Geer, J. Simonds, A. Anvery, M.Y. Chen, J.H. Burdette, M.E. Zapadka, T.L. Ellis, S.B. Tatter, G.J. Lesser, M.D. Chan, K.P. McMullen and A.J. Johnson
American Journal of Neuroradiology March 2012, 33 (3) 556-562; DOI: https://doi.org/10.3174/ajnr.A2811
C.P. Geer
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J. Simonds
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A. Anvery
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M.Y. Chen
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J.H. Burdette
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M.E. Zapadka
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T.L. Ellis
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S.B. Tatter
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G.J. Lesser
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M.D. Chan
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K.P. McMullen
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A.J. Johnson
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References

  1. 1.↵
    Central Brain Tumor Registry of the United States. CBTRUS Statistical Report: primary brain and central nervous system tumors diagnosed in the United States in 2004–2007. 2011. http://www.cbtrus.org. Accessed 2011 Feb 21.
  2. 2.↵
    1. Gutin PH,
    2. Iwamoto FM,
    3. Beal K,
    4. et al
    . Safety and efficacy of bevacizumab with hypofractionated stereotactic irradiation for recurrent malignant gliomas. Int J Radiat Oncol Biol Phys 2009;26:156–63. Epub 2009 Jan 23
  3. 3.↵
    1. Reardon DA,
    2. Fink KL,
    3. Mikkelsen T,
    4. et al
    . Randomized phase II study of cilengitide, an integrin-targeting arginine-glycine-aspartic acid peptide, in recurrent glioblastoma multiforme. J Clin Oncol 2008;26:5610–17. Epub 2008 Nov 3
    Abstract/FREE Full Text
  4. 4.↵
    1. Vredenburgh JJ,
    2. Desjardins A,
    3. Herndon JE 2nd.,
    4. et al
    . Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma. Clin Cancer Res 2007:13;1253–59
    Abstract/FREE Full Text
  5. 5.↵
    1. Fiveash JB,
    2. Spencer SA
    . Role of radiation therapy and radiosurgery in glioblastoma multiforme. Cancer J 2003;9:222–29
    CrossRefPubMed
  6. 6.↵
    1. Stupp R,
    2. Mason WP,
    3. van den Bent MJ,
    4. et al
    . Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005;352:987–96
    CrossRefPubMedWeb of Science
  7. 7.↵
    1. Kumar AJ,
    2. Leeds NE,
    3. Fuller GN,
    4. et al
    . Malignant gliomas: MR imaging spectrum of radiation therapy- and chemotherapy-induced necrosis of the brain after treatment. Radiology 2000;217:377–84
    CrossRefPubMedWeb of Science
  8. 8.↵
    1. Wen PY,
    2. Macdonald DR,
    3. Reardon DA,
    4. et al
    . Updated response assessment criteria for high-grade gliomas: response assessment in neuro-oncology working group. J Clin Oncol 2010;28:1963–72. Epub 2010 Mar 15
    Abstract/FREE Full Text
  9. 9.↵
    1. Aronen HJ,
    2. Gazit IE,
    3. Louis DN,
    4. et al
    . Cerebral blood volume maps of gliomas: comparison with tumor grade and histologic findings. Radiology 1994;191:41–51
    CrossRefPubMedWeb of Science
  10. 10.↵
    1. Aronen HJ,
    2. Glass J,
    3. Pardo FS,
    4. et al
    . Echo-planar MR cerebral blood volume mapping of gliomas: clinical utility. Acta Radiol 1995;36:520–28
    PubMed
  11. 11.↵
    1. Aronen HJ,
    2. Perkio J
    Dynamic susceptibility contrast MRI of gliomas. Neuroimaging Clin N Am 2002;12:501–23
    CrossRefPubMed
  12. 12.↵
    1. Barajas RF Jr.,
    2. Hodgson JG,
    3. Chang JS,
    4. et al
    . Glioblastoma multiforme regional genetic and cellular expression patterns: influence on anatomic and physiologic MR imaging. Radiology 2010;254:564–76
    CrossRefPubMedWeb of Science
  13. 13.↵
    1. Bisdas S,
    2. Kirkpatrick M,
    3. Giglio P,
    4. et al
    . Cerebral blood volume measurements by perfusion-weighted MR imaging in gliomas: ready for prime time in predicting short-term outcome and recurrent disease? AJNR Am J Neuroradiol 2009;30:681–88. Epub 2009 Jan 29
    Abstract/FREE Full Text
  14. 14.↵
    1. Cha S
    . Update on brain tumor imaging: from anatomy to physiology. AJNR Am J Neuroradiol 2006;27:475–87
    FREE Full Text
  15. 15.↵
    1. Cha S,
    2. Knopp EA,
    3. Johnson G,
    4. et al
    . Intracranial mass lesions: dynamic contrast-enhanced susceptibility-weighted echo-planar perfusion MR imaging. Radiology 2002;223:11–29
    CrossRefPubMedWeb of Science
  16. 16.↵
    1. Covarrubias DJ,
    2. Rosen BR,
    3. Lev MH
    . Dynamic magnetic resonance perfusion imaging of brain tumors. Oncologist 2004;9:528–37
    Abstract/FREE Full Text
  17. 17.↵
    1. Deibler AR,
    2. Pollock JM,
    3. Kraft RA,
    4. et al
    . Arterial spin-labeling in routine clinical practice. Part 3. Hyperperfusion patterns. AJNR Am J Neuroradiol 2008;29:1428–35. Epub 2008 Mar 20
    Abstract/FREE Full Text
  18. 18.↵
    1. Jackson A,
    2. Kassner A,
    3. Annesley-Williams D,
    4. et al
    . Abnormalities in the recirculation phase of contrast agent bolus passage in cerebral gliomas: comparison with relative blood volume and tumor grade. AJNR Am J Neuroradiol 2002;23:7–14
    Abstract/FREE Full Text
  19. 19.↵
    1. Kim HS,
    2. Kim SY
    . A prospective study on the added value of pulsed arterial spin-labeling and apparent diffusion coefficients in the grading of gliomas. AJNR Am J Neuroradiol 2007;28:1693–99. Epub 2007 Sep 20
    Abstract/FREE Full Text
  20. 20.↵
    1. Kim MJ,
    2. Kim HS,
    3. Kim JH,
    4. et al
    . Diagnostic accuracy and interobserver variability of pulsed arterial spin labeling for glioma grading. Acta Radiol 2008;49:450–57
    FREE Full Text
  21. 21.↵
    1. Knopp EA,
    2. Cha S,
    3. Johnson G,
    4. et al
    . Glial neoplasms: dynamic contrast-enhanced T2*-weighted MR imaging. Radiology 1999;211:791–98
    CrossRefPubMedWeb of Science
  22. 22.↵
    1. Law M,
    2. Oh S,
    3. Babb JS,
    4. et al
    . Low-grade gliomas: dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging—prediction of patient clinical response. Radiology 2006;238:658–67. Epub 2006 Jan 5
    CrossRefPubMedWeb of Science
  23. 23.↵
    1. Law M,
    2. Oh S,
    3. Johnson G,
    4. et al
    . Perfusion magnetic resonance imaging predicts patient outcome as an adjunct to histopathology: a second reference standard in the surgical and nonsurgical treatment of low-grade gliomas. Neurosurgery 2006;58:1099–107
    CrossRefPubMedWeb of Science
  24. 24.↵
    1. Law M,
    2. Yang S,
    3. Babb JS,
    4. et al
    . Comparison of cerebral blood volume and vascular permeability from dynamic susceptibility contrast-enhanced perfusion MR imaging with glioma grade. AJNR Am J Neuroradiol 2004;25:746–55
    Abstract/FREE Full Text
  25. 25.↵
    1. Law M,
    2. Yang S,
    3. Wang H,
    4. et al
    . Glioma grading: sensitivity, specificity, and predictive values of perfusion MR imaging and proton MR spectroscopic imaging compared with conventional MR imaging. AJNR Am J Neuroradiol 2003;24:1989–98
    Abstract/FREE Full Text
  26. 26.↵
    1. Law M,
    2. Young RJ,
    3. Babb JS,
    4. et al
    . Gliomas: predicting time to progression or survival with cerebral blood volume measurements at dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging. Radiology 2008;247:490–98. Epub 2008 Mar 18
    CrossRefPubMedWeb of Science
  27. 27.↵
    1. Lev MH,
    2. Ozsunar Y,
    3. Henson JW,
    4. et al
    . Glial tumor grading and outcome prediction using dynamic spin-echo MR susceptibility mapping compared with conventional contrast-enhanced MR: confounding effect of elevated rCBV of oligodendrogliomas [corrected]. AJNR Am J Neuroradiol 2004;25:214–21
    Abstract/FREE Full Text
  28. 28.↵
    1. Lev MH,
    2. Rosen BR
    . Clinical applications of intracranial perfusion MR imaging. Neuroimaging Clin N Am 1999;9:309–31
    PubMedWeb of Science
  29. 29.↵
    1. Shin JH,
    2. Lee HK,
    3. Kwun BD,
    4. et al
    . Using relative cerebral blood flow and volume to evaluate the histopathologic grade of cerebral gliomas: preliminary results. AJR Am J Roentgenol 2002;179:783–89
    CrossRefPubMed
  30. 30.↵
    1. Warmuth C,
    2. Gunther M,
    3. Zimmer C
    . Quantification of blood flow in brain tumors: comparison of arterial spin labeling and dynamic susceptibility-weighted contrast-enhanced MR imaging. Radiology 2003;228:523–32. Epub 2003 Jun 20
    CrossRefPubMedWeb of Science
  31. 31.↵
    1. Barajas RF Jr.,
    2. Chang JS,
    3. Segal MR,
    4. et al
    . Differentiation of recurrent glioblastoma multiforme from radiation necrosis after external beam radiation therapy with dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging. Radiology 2009;253:486–96. Epub 2009 Sep 29
    CrossRefPubMedWeb of Science
  32. 32.↵
    1. Hu LS,
    2. Baxter LC,
    3. Smith KA,
    4. et al
    . Relative cerebral blood volume values to differentiate high-grade glioma recurrence from posttreatment radiation effect: direct correlation between image-guided tissue histopathology and localized dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging measurements. AJNR Am J Neuroradiol 2009;30:552–58. Epub 2008 Dec 4
    Abstract/FREE Full Text
  33. 33.↵
    1. Sugahara T,
    2. Korogi Y,
    3. Tomiguchi S,
    4. et al
    . Posttherapeutic intraaxial brain tumor: the value of perfusion-sensitive contrast-enhanced MR imaging for differentiating tumor recurrence from nonneoplastic contrast-enhancing tissue. AJNR Am J Neuroradiol 2000;21:901–09
    Abstract/FREE Full Text
  34. 34.↵
    1. Hollingworth W,
    2. Jarvik JG
    . Technology assessment in radiology: putting the evidence in evidence-based radiology. Radiology 2007;244:31–38. Epub 2007 May 23
    CrossRefPubMedWeb of Science
  35. 35.↵
    1. Deibler AR,
    2. Pollock JM,
    3. Kraft RA,
    4. et al
    . Arterial spin-labeling in routine clinical practice. Part 1. Technique and artifacts. AJNR Am J Neuroradiol 2008;29:1228–34. Epub 2008 Mar 27
    Abstract/FREE Full Text
  36. 36.↵
    1. Luh WM,
    2. Wong EC,
    3. Bandettini PA,
    4. et al
    . QUIPSS II with thin-slice TI1 periodic saturation: a method for improving accuracy of quantitative perfusion imaging using pulsed arterial spin labeling. Magn Reson Med 1999;41:1246–54
    CrossRefPubMedWeb of Science
  37. 37.↵
    1. Kim SG,
    2. Tsekos NV
    . Perfusion imaging by a flow-sensitive alternating inversion recovery (FAIR) technique: application to functional brain imaging. Magn Reson Med 1997;37:425–35
    PubMedWeb of Science
  38. 38.↵
    1. Kim SG,
    2. Tsekos NV,
    3. Ashe J
    . Multi-slice perfusion-based functional MRI using the FAIR technique: comparison of CBF and BOLD effects. NMR Biomed 1997;10:191–96
    CrossRefPubMed
  39. 39.↵
    1. Kong DS,
    2. Kim ST,
    3. Kim EH,
    4. et al
    . Diagnostic dilemma of pseudoprogression in the treatment of newly diagnosed glioblastomas: the role of assessing relative cerebral blood flow volume and oxygen-6-methylguanine-DNA methyltransferase promoter methylation status. AJNR Am J Neuroradiol 2011;32:382–87. Epub 2011 Jan 20
    Abstract/FREE Full Text
  40. 40.↵
    1. Jain R,
    2. Gutierrez J,
    3. Narang J,
    4. et al
    . In vivo correlation of tumor blood volume and permeability with histologic and molecular angiogenic markers in gliomas. AJNR Am J Neuroradiol 2011;32:388–94. Epub 2010 Nov 11
    Abstract/FREE Full Text
  41. 41.↵
    1. Nabors LB,
    2. Mikkelsen T,
    3. Rosenfeld SS,
    4. et al
    . Phase I and correlative biology study of cilengitide in patients with recurrent malignant glioma. J Clin Oncol 2007;25:1651–57
    Abstract/FREE Full Text
  42. 42.↵
    1. Price SJ,
    2. Green HA,
    3. Dean AF,
    4. et al
    . Correlation of MR relative cerebral blood volume measurements with cellular density and proliferation in high-grade gliomas: an image-guided biopsy study. AJNR Am J Neuroradiol 2011;32:501–06. Epub 2010 Dec 16
    Abstract/FREE Full Text
  43. 43.↵
    1. Ozsunar Y,
    2. Mullins ME,
    3. Kwong K,
    4. et al
    . Glioma recurrence versus radiation necrosis? A pilot comparison of arterial spin-labeled, dynamic susceptibility contrast enhanced MRI, and FDG-PET imaging. Acad Radiol 2010;17:282–90. Epub 2010 Jan 12
    CrossRefPubMed
  44. 44.↵
    1. Johnson AJ,
    2. Ying J,
    3. El Gammal T,
    4. et al
    . Which MR imaging sequences are necessary in determining the need for radiation therapy for cord compression? A prospective study. AJNR Am J Neuroradiol 2007;28:32–37
    Abstract/FREE Full Text
  45. 45.↵
    1. Yin Y,
    2. Evanoff BA,
    3. Gilula LA,
    4. et al
    . Surgeons' decision making in patients with chronic wrist pain: role of bilateral three-compartment wrist arthrography—prospective study. Radiology 1996;200:829–32
    PubMed
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C.P. Geer, J. Simonds, A. Anvery, M.Y. Chen, J.H. Burdette, M.E. Zapadka, T.L. Ellis, S.B. Tatter, G.J. Lesser, M.D. Chan, K.P. McMullen, A.J. Johnson
Does MR Perfusion Imaging Impact Management Decisions for Patients with Brain Tumors? A Prospective Study
American Journal of Neuroradiology Mar 2012, 33 (3) 556-562; DOI: 10.3174/ajnr.A2811

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Does MR Perfusion Imaging Impact Management Decisions for Patients with Brain Tumors? A Prospective Study
C.P. Geer, J. Simonds, A. Anvery, M.Y. Chen, J.H. Burdette, M.E. Zapadka, T.L. Ellis, S.B. Tatter, G.J. Lesser, M.D. Chan, K.P. McMullen, A.J. Johnson
American Journal of Neuroradiology Mar 2012, 33 (3) 556-562; DOI: 10.3174/ajnr.A2811
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  • ASFNR Recommendations for Clinical Performance of MR Dynamic Susceptibility Contrast Perfusion Imaging of the Brain
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