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Research ArticleBrainF

Does MR Perfusion Imaging Impact Management Decisions for Patients with Brain Tumors? A Prospective Study

C.P. Geer, J. Simonds, A. Anvery, M.Y. Chen, J.H. Burdette, M.E. Zapadka, T.L. Ellis, S.B. Tatter, G.J. Lesser, M.D. Chan, K.P. McMullen and A.J. Johnson
American Journal of Neuroradiology March 2012, 33 (3) 556-562; DOI: https://doi.org/10.3174/ajnr.A2811
C.P. Geer
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J. Simonds
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A. Anvery
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M.Y. Chen
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J.H. Burdette
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M.E. Zapadka
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T.L. Ellis
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S.B. Tatter
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G.J. Lesser
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M.D. Chan
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K.P. McMullen
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A.J. Johnson
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    Fig 1.

    A and C, Postcontrast SPGR image for reference MRI (C) shows new enhancement along the right anterior limb of the internal capsule, which was not present on comparison postcontrast SPGR (A). B and D, This area shows increased CBV on the concurrent DSC color map (D) compared with the prior DSC color map (B). The appearance was most suggestive of tumor progression, and the management plan was altered accordingly. Susceptibility artifacts are seen along the previous resection cavity in the right temporoparietal region on all images.

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    Fig 2.

    Pie chart shows the effect of the addition of perfusion imaging on treatment-team confidence in their chosen management plan.

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    Fig 3.

    Bar graph shows the frequency of the perceived usefulness of perfusion imaging in these study subjects.

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    Fig 4.

    Bar graph shows the relative frequencies that specific perfusion techniques were thought most useful by NRs and the treatment team.

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    Table 1:

    Tumor status estimations for subjects by NRs and the treatment teama

    NRs
    ImprovedStableProgressed
    Treatment teamImproved3 (6)
    Stable1 (2)27 (54)3 (6)
    Progressed1 (2)15 (30)
    • ↵a Total cases (N = 50). Numbers in parentheses are percentages.

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    Table 2:

    Effect of perfusion imaging on confidence in determination of tumor statusa

    Increased ConfidenceNo Change in ConfidenceDecreased Confidence
    NRs20 (40)24 (48)6 (12)
    Treatment team28 (56)12 (24)10 (20)
    • ↵a N = 50 cases with previous tissue diagnoses. Numbers in parentheses are percentages.

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    Table 3:

    Specific changes in management plans with the addition of perfusion images

    PatientPatient Age (yr)/SexPrevious PathologyEffect of PerfusionChange in Management Plan
    A54/MGBMConfidence in tumor progression decreasedCancelled biopsy and short-interval follow-up MRI
    B56/MGrade II astrocytomaConfidence in tumor progression increasedShorter interval to follow-up MRI
    C51/MGrade II astrocytomaConfidence in tumor progression increasedRoutine follow-up MRI changed to re-resection
    D51/FGBMConfidence in tumor progression increasedShort-term follow-up MRI changed to enrollment in a therapeutic trial
    E55/MGBMConfidence in stable disease decreasedShorter interval to follow-up MRI
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American Journal of Neuroradiology: 33 (3)
American Journal of Neuroradiology
Vol. 33, Issue 3
1 Mar 2012
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Cite this article
C.P. Geer, J. Simonds, A. Anvery, M.Y. Chen, J.H. Burdette, M.E. Zapadka, T.L. Ellis, S.B. Tatter, G.J. Lesser, M.D. Chan, K.P. McMullen, A.J. Johnson
Does MR Perfusion Imaging Impact Management Decisions for Patients with Brain Tumors? A Prospective Study
American Journal of Neuroradiology Mar 2012, 33 (3) 556-562; DOI: 10.3174/ajnr.A2811

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Does MR Perfusion Imaging Impact Management Decisions for Patients with Brain Tumors? A Prospective Study
C.P. Geer, J. Simonds, A. Anvery, M.Y. Chen, J.H. Burdette, M.E. Zapadka, T.L. Ellis, S.B. Tatter, G.J. Lesser, M.D. Chan, K.P. McMullen, A.J. Johnson
American Journal of Neuroradiology Mar 2012, 33 (3) 556-562; DOI: 10.3174/ajnr.A2811
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  • Arterial Spin-Labeling and DSC Perfusion Metrics Improve Agreement in Neuroradiologists Clinical Interpretations of Posttreatment High-Grade Glioma Surveillance MR Imaging--An Institutional Experience
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  • ASFNR Recommendations for Clinical Performance of MR Dynamic Susceptibility Contrast Perfusion Imaging of the Brain
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