Article Figures & Data
Figures
- Fig 1.
A and B, Verb-generation task statistical activations from group-level ICA-GLM analysis in the control (n = 12) and patient (n = 22) groups, respectively (P < .01, FDR-corrected for multiple comparisons; only clusters >10 mm2 are represented). C, Predefined seed regions of interest for the FC analysis are superimposed on the conjunction plots, displaying common activated voxels in controls and in patients in both LE and RE subgroups. All seed centers were found to be included within the activated shared voxels.
- Fig 2.
Plots and matrices representing FC links among the 6 language-network regions in both hemispheres evaluated in this study (left panel) in controls (n = 12) and all patients (n = 22). Connectivity plots (upper row) show statistically significant correlations by means of red lines of variable thickness according to the z scores, from Pearson coefficient values. These are further represented in the corresponding color-coded matrices (lower row), ranging from white (z = 0) to dark red (z = 0.7). Only correlations significant at P < .01 are shown. The right panel shows a statistical comparison between the groups (independent t test, P < .01). Significantly reduced FC links in patients are indicated by black lines and quantified in the corresponding color-coded matrices (color scale for z score representation is the same as that in the left panel). Line thickness varies according to the reduction of correlation values.
- Fig 3.
Plots and matrices representing FC links among the 6 language-network regions in both hemispheres evaluated in this study (left panel) in patients with LE (n = 11) and RE (n = 11). Connectivity plots (upper row) show statistically significant correlations by means of red lines of variable thickness according to the z scores, from Pearson coefficient values. These are further represented in the corresponding color-coded matrices (lower row), ranging from white (z = 0) to dark red (z = 0.7). Only correlations significant at P < .01 are shown.
- Fig 4.
FC statistical maps displaying correlation z scores between L-T1p (black dots) and the rest of the brain, superimposed on inflated 3D templates for anatomic reference (P < .01, FDR-corrected for multiple comparisons). Patient maps (B) lack several connectivity links with the rest of the language network compared with controls (A). However, contrary to controls, the patient group presents statistically significant correlations with the left PCC (white circles).
Tables
Patient No. Age SO (yr) SF Lobe Etiology 1 36 10 W Frontal Micropolygyria 2 49 10 M Temporal MTS 3 27 19 M Frontal DNET 4 51 28 M Temporal Cortical dysplasia 5 26 20 W Temporal Cavernoma 6 19 0.7 M Temporal MTS 7 29 2 W Temporal MTS 8 23 7 W Frontal DNET 9 32 10 W Temporal MTS 10 16 12 D Temporal MTS 11 16 8 W Temporal MTS 12 35 15 M Temporal Cryptogenetic 13 28 16 M Temporal Cryptogenetic 14 22 20 D Temporal DNET 15 22 0.5 D Frontal Cryptogenetic 16 33 30 D Frontal Cryptogenetic 17 34 26 D Temporal MTS 18 28 3 W Temporal MTS 19 46 38 M Frontal AVM 20 36 8 M Temporal MTS 21 29 12 M Temporal Micropolygyria 22 18 11 W Temporal MTS
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