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Research ArticleBrain

Middle Cerebral Artery Infarction: Relationship of Cavernous Carotid Artery Calcification

Lukasz S. Babiarz, David M. Yousem, Warren Bilker and Bruce A. Wasserman
American Journal of Neuroradiology June 2005, 26 (6) 1505-1511;
Lukasz S. Babiarz
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David M. Yousem
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Warren Bilker
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Bruce A. Wasserman
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  • Fig 1.
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    Fig 1.

    Scoring system.

    A, Grade 1. Small dot of calcification 1 mm thick is present in the left CCA wall. Grades for this plaque are 1 for extent and 1 for thickness.

    B, Grade 2. CT scan of the right CCA shows an atherosclerotic, calcified plaque that is crescentic but <90° of the vascular circumference. Grades are 2 for extent and 1 (1 mm) for thickness.

    C, Grade 3. Circumferential involvement of the right CCA calcification is 90° but <270°; therefore, the grade is 3 for extent.

    D, Grade 4. Both carotid arteries show complete circumferential involvement with atherosclerotic plaque, hence grade 4.

Tables

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    TABLE 1:

    CCA calcification scale

    GradeCalcification
    ExtentThickness (mm)
    0None0
    1Dot1
    2<90° of carotid wall circumference2
    390–270° of circumference3
    4270–360° of circumference>3
    • View popup
    TABLE 2:

    Population demographic data by infarction type

    DataMCA Group (n = 40)Non-MCA Group (n = 34)Control Group (n = 94)
    Cerebrovascular infarctionYesYesNo
    Patient age (y)
        Mean ± SD64.3 ± 13.264.2 ± 13.363.8 ± 12.0
        Range41–8642–8341–86
    • View popup
    TABLE 3:

    CT scores and thicknesses by infarction group

    CT Score and Thickness (mm)MCA Group (n = 40)Non-MCA Group (n = 34)Control Group (n = 94)
    LeftRightLeftRight
    CT score 01214101027
    CT score 1
        1748618
        202336
        300000
        4NANA10NA
    CT score 2
        151037
        225025
        300010
        4NANANANA0
        5NANANANA2
    CT score 3
        1253310
        231334
        310102
        410NANANA
    Ct score 4
        124017
        233424
        321101
        4NANANANA1
    • View popup
    TABLE 4:

    Sumary of calcification scores

    Grade and GroupMeanMaximum
    CT score
        MCA1.73 ± 1.45 (0–4)1.98 ± 1.53 (0–4)
        Non-MCA1.53 ± 1.37 (0–4)1.74 ± 1.46 (0–4)
        ControlNA1.62 ± 1.42 (0–4)
    CT thickness (mm)
        MCA1.05 ± 0.82 (0–3)1.28 ± 1.04 (0–4)
        Non-MCA1.13 ± 0.82 (0–3)1.35 ± 1.01 (0–4)
        ControlNA1.10 ± 1.03 (0–5)
    CT score and thickness
        MCA2.78 ± 2.16 (0–7)3.26 ± 2.38 (0–7)
        Non-MCA2.66 ± 2.04 (0–6)3.09 ± 2.25 (0–7)
        ControlNA2.72 ± 2.17 (0–8)
    • Note.—NA = not applicable; for control cases only the higher (maximum) calcification score of the left and right side was recorded.

    • View popup
    TABLE 5:

    Summary of calcification scores in the MCA plus non-MCA groups

    GradeInfarction SideContralateral SideP Value *
    CT score1.5 ± 1.48 (0–4)1.47 ± 1.49 (0–4).76
    CT thickness (mm)1.15 ± 1.09 (0–4)0.97 ± 0.90 (0–4).67
    CT score and thickness2.68 ± 2.40 (0–7)2.44 ± 2.21 (0–7).50
    • Note.—Data are the value ± SD (range).

    • * Fisher exact test.

    • View popup
    TABLE 6:

    Comparison of calcification groups

    Comparison and Calcification CriterionP Value
    Mann-Whitney Test, UnadjustedMedian Regression, Adjusted for Age
    All stroke vs all controls
        Maximum
            Circumference.230.550
            Thickness.089<.001
            Circumference + thickness.156.552
        Mean
            Circumference.881.999
            Thickness.511.776
            Circumference + thickness.873.594
    MCA stroke vs non-MCA stroke
        Maximum
            Circumference.391.308
            Thickness.194.857
            Circumference + thickness.328.799
        Mean
            Circumference.365.141
            Thickness.183.309
            Circumference + thickness.254.238
    MCA stroke vs MCA controls
        Maximum
            Circumference.075.446
            Thickness.107.390
            Circumference + thickness.060.326
        Mean
            Circumference.250.791
            Thickness.369.999
            Circumference + thickness.329.784
    Non-MCA stroke vs non-MCA controls
        Maximum
            Circumference.636.353
            Thickness.449.999
            Circumference + thickness.963.388
        Mean
            Circumference.272.342
            Thickness.992.999
            Circumference + thickness.395.256
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American Journal of Neuroradiology: 26 (6)
American Journal of Neuroradiology
Vol. 26, Issue 6
1 Jun 2005
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Cite this article
Lukasz S. Babiarz, David M. Yousem, Warren Bilker, Bruce A. Wasserman
Middle Cerebral Artery Infarction: Relationship of Cavernous Carotid Artery Calcification
American Journal of Neuroradiology Jun 2005, 26 (6) 1505-1511;

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Middle Cerebral Artery Infarction: Relationship of Cavernous Carotid Artery Calcification
Lukasz S. Babiarz, David M. Yousem, Warren Bilker, Bruce A. Wasserman
American Journal of Neuroradiology Jun 2005, 26 (6) 1505-1511;
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