Article Figures & Data
Figures
- fig 1.
ROIs used for the analysis of cerebral perfusion. ROIs were placed on six regions in the brain parenchyma of each hemisphere. The ROIs were obtained from four slices on 133Xe-SPECT scans and from two to four slices from PWI images. ROI 1 corresponded to the left ACA territory, ROI 2 to the left ABZ territory, ROIs 3 and 4 to the left MCA territory, ROI 5 to the left PBZ territory, and ROI 6 to the left PCA territory. ROIs 7 through 12 corresponded to the same territories in the right hemisphere. The ROI setting was consistent between 133Xe-SPECT and PWI. Data from 10 regions were obtained for each patient
- fig 2.
Example of PWI and 133Xe-SPECT studies in patient 7.
A, Comparison of the AIFs obtained from the ICA and MCA. Note that they vary slightly and that the AIF from the ICA is somewhat better than that from the MCA.
B, rCBF image generated from PWI (rCBF-PWI).
C, rCBV image generated from PWI (rCBV-PWI).
D, 133Xe-SPECT scan. Note that images generated from PWI were superior to 133Xe-SPECT scan in spatial resolution, and that rCBF and rCBV values in the deep brain structure can be evaluated on rCBF-PWI and rCBV-PWI images.
- fig 3.
Relationship between the rCBF values obtained from 133Xe-SPECT (rCBF-SPECT) and those obtained PWI (rCBF-PWI). A significant correlation was found between them (r = .648, P < .0001, n = 78)
- fig 4.
A–C, Box-and-whisker plot of rCBF-SPECT (A), rCBF-PWI (B), and rCBV-PWI (C) in the regions with severely decreased (% increase ≤ 0%), moderately decreased (0 < % increase ≤ 15%), and normal (15% < % increase) perfusion reserve. % increase was defined as [(post-rCBF) − (pre-rCBF)]/(pre-rCBF) × 100, where pre-rCBF and post-rCBF denote the CBF values before and after acetazolamide CBF as measured on 133Xe-SPECT scans, respectively. Boxes represent 25% to 70% range with bisecting lines showing medium values; horizontal lines represent 10% to 90% range; NS indicates not significant. Note that the regions with severely decreased perfusion reserve show significantly lower rCBF values on 133Xe-SPECT (A) and rCBF-PWI (B) studies than do those with moderately decreased or normal perfusion reserve. They also show significantly higher rCBV values on rCBV-PWI study (C) than do those with moderately decreased or normal perfusion reserve.
Tables
Data for eight patients with occlusive carotid disease
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