- Glial Fibrillary Acidic Protein Astrocytopathy: Review of Pathogenesis, Imaging Features, and Radiographic Mimics
Glial fibrillary acidic protein (GFAP) astrocytopathy is a CNS autoimmune inflammatory disorder characterized by specific antibodies targeting the intracellular filament protein in mature astrocytes. Neuroimaging findings include linear perivascular enhancement in the white matter extending in a radial pattern, periependymal enhancement, longitudinally extensive cord signal changes, intramedullary enhancement, optic neuritis, and papillitis.
- Radiologic Classification of Hippocampal Sclerosis in Epilepsy
This review explores how the International League Against Epilepsy (ILAE) subtypes of hippocampal sclerosis correlate with MRI findings. Hippocampal anatomy is reviewed in detail. The pathophysiology of hippocampal sclerosis is discussed. A radiologic classification scheme is proposed that aligns with the ILAE pathology classification, aiming to improve clinical communication and decision-making.
- Multiparametric Characterization and Spatial Distribution of Different MS Lesion Phenotypes
Lesion phenotype (ie, different levels of axonal and myelin loss and spatial distribution) was characterized using quantitative susceptibility mapping, susceptibility-weighted imaging, T1-relaxometry, myelin mapping, and diffusion MRI. A more severe disease course was observed in hyperintense and paramagnetic rim lesions in the periventricular white matter.
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