Article Figures & Data
Figures
- FIG 1.
Measurements of ASPECTS-NWU and Region-NWU by RAPID ASPECTS software. A, The RAPID software shows an ASPECTS score of 6. The ischemic regions were the lentiform, insula, M3, and M6. Each region had a corresponding CT value. B, A 48-hour follow-up CT scan shows MCE in this patient. C, Calculations of the ASPECTS-NWU and Region-NWU according to the Equation. HUischemic was 30.38 (the mean HU of the 4 ischemic ASPECTS regions [lentiform, insula, M3, and M6]). HUnormal was 32.18 (the mean HU of the respective normal ipsilateral ASPECTS regions). Region-HUinsula was 28.3. Region-HUnormal was 30.2.
- FIG 2.
Flow chart of patient selection for the study.
- FIG 3.
The smoothing spline plots show the relationship between NWU and MCE. A, The relationship between ASPECTS-NWU and MCE risk, stratified by insula involvement. When infarcts involved the insula (hollow circles), ASPECTS-NWU and the risk of MCE increased, whereas when the infarcts did not involve the insula (black circles), this association was absent. B, The association between the Insula-NWU and MCE (black circle dotted line). The area between the 2 hollow circle lines is the 95% CI.
- FIG 4.
ROC analysis resulted in AUCs of 0.64 and 0.70 for ASPECTS-NWU and Insula-NWU, respectively. The multivariate regression model combining NIHSS, ASPECTS, insula involvement, and Insula-NWU resulted in an AUC of 0.80. The diagnostic power of Insula-NWU is superior to that of ASPECTS-NWU by the DeLong test (P = .01), and the diagnostic power of the model is superior to that of Insula-NWU (P < .01).
Tables
Clinical and imaging characteristics of the patient population
Variable All MCE– MCE+ P Value Age (mean) (yr) 67.43 (SD 12.33) 67.10 (SD 12.55) 68.54 (SD 11.55) .27 Male sex, No. (%) 314 (61%) 241 (61%) 73 (63%) .67 NIHSS score at baseline (mean) 14.88 (SD 6.57) 13.94 (SD 6.53) 18.12 (SD 5.63) <.01 Time from stroke onset to CT (mean) (h) 4.60 (SD 4.23) 4.63 (SD 4.47) 4.49 (SD 3.31) .77 ASPECTS (mean) 6.11 (SD 2.83) 6.58 (SD 2.57) 4.52 (SD 3.09) <.01 ASPECTS-NWU (mean) 5.87 (SD 3.87) 5.49 (SD 3.79) 7.20 (SD 3.85) <.1 Blood glucose (mmol/L) (mean) 7.6 (SD 2.8) 7.44 (SD 2.77) 8.20 (SD 3.04) .01 Risk factors Diabetes mellitus, No. (%) 125 (24%) 100 (25%) 25 (22%) .41 Hypertension, No. (%) 329 (64%) 252 (64%) 77 (66%) .59 Previous ischemic stroke or TIA, No. (%) 101 (20%) 76 (19%) 25 (22%) .57 Atrial fibrillation, No. (%) 167 (33%) 126 (32%) 41 (35%) .47 Coronary artery disease, No. (%) 67 (13%) 50 (13%) 17 (15%) .56 Occlusion site .01 ICA, No. (%) 158 (38%) 109 (35%) 49 (50%) MCA-M1 segment, No. (%) 231 (56%) 184 (58%) 47 (48%) MCA-M2 segment, No. (%) 24 (6%) 22 (7%) 2 (2%) ASPECTS region, No. (%) M1 191 (37%) 126 (32%) 65 (56%) <.01 M2 182 (35%) 119 (30%) 63 (54%) <.01 M3 141 (27%) 90 (23%) 51 (44%) <.01 M4 140 (27%) 94 (24%) 46 (40%) <.01 M5 172 (34%) 108 (27%) 64 (55%) <.01 M6 135 (26%) 87 (22%) 48 (41%) <.01 Insula 285 (56%) 195 (49%) 90 (78%) <.01 Lentiform nucleus 248 (48%) 176 (44%) 72 (62%) <.01 Internal capsule 231 (45%) 164 (41%) 67 (58%) .02 Caudate nucleus 264 (51%) 194 (49%) 70 (60%) .03
Jump to section
Related Articles
Cited By...
- No citing articles found.