Automated Diffusion Analysis for Non-Invasive Prediction of IDH Genotype in WHO Grade 2-3 Gliomas

From the Centre for Medical Image Computing (CMIC), Department of Medical Physics and Biomedical Engineering, University College London, London, UK (JW, FPC, FB), Neuroradiological Academic Unit, UCL Queen Square Institute of Neurology, University College London, London, UK (JW, ST, SW, JM, FB), Radiological Sciences, Mental Health and Neurosciences, School of Medicine, University of Nottingham, Nottingham, UK (ST), Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, UK (ST), NIHR Nottingham Biomedical Research Center, Nottingham, UK (ST), Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, UK (SW, GA, MB, JM, FB), Department of Neuroradiology, King's College Hospital NHS Foundation Trust, London, United Kingdom (GA), Department of Radiology, Mansoura University hospitals, Mansoura Faculty of Medicine, Egypt (GA), Department of Diagnostic Imaging and Radiotherapy, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy (MB), Department of Radiology, Guy's and St Thomas' NHS Foundation Trust, London, UK (JM), Department of Neurodegenerative Disease, UCL Institute of Neurology and Division of Neuropathology, National Hospital for Neurology and Neurosurgery, University College London NHS Foundation Trust, London (SB), Department of Neuroinflammation, Faculty of Brain Sciences, Queen Square MS Center, UCL Institute of Neurology, University College London, London, UK (FPC), e-Health Center, Universitat Oberta de Catalunya, Barcelona, Spain (FPC), Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands (FB).

From the Centre for Medical Image Computing (CMIC), Department of Medical Physics and Biomedical Engineering, University College London, London, UK (JW, FPC, FB), Neuroradiological Academic Unit, UCL Queen Square Institute of Neurology, University College London, London, UK (JW, ST, SW, JM, FB), Radiological Sciences, Mental Health and Neurosciences, School of Medicine, University of Nottingham, Nottingham, UK (ST), Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, UK (ST), NIHR Nottingham Biomedical Research Center, Nottingham, UK (ST), Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, UK (SW, GA, MB, JM, FB), Department of Neuroradiology, King's College Hospital NHS Foundation Trust, London, United Kingdom (GA), Department of Radiology, Mansoura University hospitals, Mansoura Faculty of Medicine, Egypt (GA), Department of Diagnostic Imaging and Radiotherapy, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy (MB), Department of Radiology, Guy's and St Thomas' NHS Foundation Trust, London, UK (JM), Department of Neurodegenerative Disease, UCL Institute of Neurology and Division of Neuropathology, National Hospital for Neurology and Neurosurgery, University College London NHS Foundation Trust, London (SB), Department of Neuroinflammation, Faculty of Brain Sciences, Queen Square MS Center, UCL Institute of Neurology, University College London, London, UK (FPC), e-Health Center, Universitat Oberta de Catalunya, Barcelona, Spain (FPC), Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands (FB).

From the Centre for Medical Image Computing (CMIC), Department of Medical Physics and Biomedical Engineering, University College London, London, UK (JW, FPC, FB), Neuroradiological Academic Unit, UCL Queen Square Institute of Neurology, University College London, London, UK (JW, ST, SW, JM, FB), Radiological Sciences, Mental Health and Neurosciences, School of Medicine, University of Nottingham, Nottingham, UK (ST), Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, UK (ST), NIHR Nottingham Biomedical Research Center, Nottingham, UK (ST), Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, UK (SW, GA, MB, JM, FB), Department of Neuroradiology, King's College Hospital NHS Foundation Trust, London, United Kingdom (GA), Department of Radiology, Mansoura University hospitals, Mansoura Faculty of Medicine, Egypt (GA), Department of Diagnostic Imaging and Radiotherapy, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy (MB), Department of Radiology, Guy's and St Thomas' NHS Foundation Trust, London, UK (JM), Department of Neurodegenerative Disease, UCL Institute of Neurology and Division of Neuropathology, National Hospital for Neurology and Neurosurgery, University College London NHS Foundation Trust, London (SB), Department of Neuroinflammation, Faculty of Brain Sciences, Queen Square MS Center, UCL Institute of Neurology, University College London, London, UK (FPC), e-Health Center, Universitat Oberta de Catalunya, Barcelona, Spain (FPC), Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands (FB).

From the Centre for Medical Image Computing (CMIC), Department of Medical Physics and Biomedical Engineering, University College London, London, UK (JW, FPC, FB), Neuroradiological Academic Unit, UCL Queen Square Institute of Neurology, University College London, London, UK (JW, ST, SW, JM, FB), Radiological Sciences, Mental Health and Neurosciences, School of Medicine, University of Nottingham, Nottingham, UK (ST), Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, UK (ST), NIHR Nottingham Biomedical Research Center, Nottingham, UK (ST), Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, UK (SW, GA, MB, JM, FB), Department of Neuroradiology, King's College Hospital NHS Foundation Trust, London, United Kingdom (GA), Department of Radiology, Mansoura University hospitals, Mansoura Faculty of Medicine, Egypt (GA), Department of Diagnostic Imaging and Radiotherapy, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy (MB), Department of Radiology, Guy's and St Thomas' NHS Foundation Trust, London, UK (JM), Department of Neurodegenerative Disease, UCL Institute of Neurology and Division of Neuropathology, National Hospital for Neurology and Neurosurgery, University College London NHS Foundation Trust, London (SB), Department of Neuroinflammation, Faculty of Brain Sciences, Queen Square MS Center, UCL Institute of Neurology, University College London, London, UK (FPC), e-Health Center, Universitat Oberta de Catalunya, Barcelona, Spain (FPC), Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands (FB).

From the Centre for Medical Image Computing (CMIC), Department of Medical Physics and Biomedical Engineering, University College London, London, UK (JW, FPC, FB), Neuroradiological Academic Unit, UCL Queen Square Institute of Neurology, University College London, London, UK (JW, ST, SW, JM, FB), Radiological Sciences, Mental Health and Neurosciences, School of Medicine, University of Nottingham, Nottingham, UK (ST), Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, UK (ST), NIHR Nottingham Biomedical Research Center, Nottingham, UK (ST), Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, UK (SW, GA, MB, JM, FB), Department of Neuroradiology, King's College Hospital NHS Foundation Trust, London, United Kingdom (GA), Department of Radiology, Mansoura University hospitals, Mansoura Faculty of Medicine, Egypt (GA), Department of Diagnostic Imaging and Radiotherapy, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy (MB), Department of Radiology, Guy's and St Thomas' NHS Foundation Trust, London, UK (JM), Department of Neurodegenerative Disease, UCL Institute of Neurology and Division of Neuropathology, National Hospital for Neurology and Neurosurgery, University College London NHS Foundation Trust, London (SB), Department of Neuroinflammation, Faculty of Brain Sciences, Queen Square MS Center, UCL Institute of Neurology, University College London, London, UK (FPC), e-Health Center, Universitat Oberta de Catalunya, Barcelona, Spain (FPC), Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands (FB).

From the Centre for Medical Image Computing (CMIC), Department of Medical Physics and Biomedical Engineering, University College London, London, UK (JW, FPC, FB), Neuroradiological Academic Unit, UCL Queen Square Institute of Neurology, University College London, London, UK (JW, ST, SW, JM, FB), Radiological Sciences, Mental Health and Neurosciences, School of Medicine, University of Nottingham, Nottingham, UK (ST), Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, UK (ST), NIHR Nottingham Biomedical Research Center, Nottingham, UK (ST), Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, UK (SW, GA, MB, JM, FB), Department of Neuroradiology, King's College Hospital NHS Foundation Trust, London, United Kingdom (GA), Department of Radiology, Mansoura University hospitals, Mansoura Faculty of Medicine, Egypt (GA), Department of Diagnostic Imaging and Radiotherapy, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy (MB), Department of Radiology, Guy's and St Thomas' NHS Foundation Trust, London, UK (JM), Department of Neurodegenerative Disease, UCL Institute of Neurology and Division of Neuropathology, National Hospital for Neurology and Neurosurgery, University College London NHS Foundation Trust, London (SB), Department of Neuroinflammation, Faculty of Brain Sciences, Queen Square MS Center, UCL Institute of Neurology, University College London, London, UK (FPC), e-Health Center, Universitat Oberta de Catalunya, Barcelona, Spain (FPC), Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands (FB).

From the Centre for Medical Image Computing (CMIC), Department of Medical Physics and Biomedical Engineering, University College London, London, UK (JW, FPC, FB), Neuroradiological Academic Unit, UCL Queen Square Institute of Neurology, University College London, London, UK (JW, ST, SW, JM, FB), Radiological Sciences, Mental Health and Neurosciences, School of Medicine, University of Nottingham, Nottingham, UK (ST), Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, UK (ST), NIHR Nottingham Biomedical Research Center, Nottingham, UK (ST), Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, UK (SW, GA, MB, JM, FB), Department of Neuroradiology, King's College Hospital NHS Foundation Trust, London, United Kingdom (GA), Department of Radiology, Mansoura University hospitals, Mansoura Faculty of Medicine, Egypt (GA), Department of Diagnostic Imaging and Radiotherapy, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy (MB), Department of Radiology, Guy's and St Thomas' NHS Foundation Trust, London, UK (JM), Department of Neurodegenerative Disease, UCL Institute of Neurology and Division of Neuropathology, National Hospital for Neurology and Neurosurgery, University College London NHS Foundation Trust, London (SB), Department of Neuroinflammation, Faculty of Brain Sciences, Queen Square MS Center, UCL Institute of Neurology, University College London, London, UK (FPC), e-Health Center, Universitat Oberta de Catalunya, Barcelona, Spain (FPC), Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands (FB).

From the Centre for Medical Image Computing (CMIC), Department of Medical Physics and Biomedical Engineering, University College London, London, UK (JW, FPC, FB), Neuroradiological Academic Unit, UCL Queen Square Institute of Neurology, University College London, London, UK (JW, ST, SW, JM, FB), Radiological Sciences, Mental Health and Neurosciences, School of Medicine, University of Nottingham, Nottingham, UK (ST), Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, UK (ST), NIHR Nottingham Biomedical Research Center, Nottingham, UK (ST), Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, UK (SW, GA, MB, JM, FB), Department of Neuroradiology, King's College Hospital NHS Foundation Trust, London, United Kingdom (GA), Department of Radiology, Mansoura University hospitals, Mansoura Faculty of Medicine, Egypt (GA), Department of Diagnostic Imaging and Radiotherapy, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy (MB), Department of Radiology, Guy's and St Thomas' NHS Foundation Trust, London, UK (JM), Department of Neurodegenerative Disease, UCL Institute of Neurology and Division of Neuropathology, National Hospital for Neurology and Neurosurgery, University College London NHS Foundation Trust, London (SB), Department of Neuroinflammation, Faculty of Brain Sciences, Queen Square MS Center, UCL Institute of Neurology, University College London, London, UK (FPC), e-Health Center, Universitat Oberta de Catalunya, Barcelona, Spain (FPC), Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands (FB).

From the Centre for Medical Image Computing (CMIC), Department of Medical Physics and Biomedical Engineering, University College London, London, UK (JW, FPC, FB), Neuroradiological Academic Unit, UCL Queen Square Institute of Neurology, University College London, London, UK (JW, ST, SW, JM, FB), Radiological Sciences, Mental Health and Neurosciences, School of Medicine, University of Nottingham, Nottingham, UK (ST), Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, UK (ST), NIHR Nottingham Biomedical Research Center, Nottingham, UK (ST), Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, UK (SW, GA, MB, JM, FB), Department of Neuroradiology, King's College Hospital NHS Foundation Trust, London, United Kingdom (GA), Department of Radiology, Mansoura University hospitals, Mansoura Faculty of Medicine, Egypt (GA), Department of Diagnostic Imaging and Radiotherapy, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy (MB), Department of Radiology, Guy's and St Thomas' NHS Foundation Trust, London, UK (JM), Department of Neurodegenerative Disease, UCL Institute of Neurology and Division of Neuropathology, National Hospital for Neurology and Neurosurgery, University College London NHS Foundation Trust, London (SB), Department of Neuroinflammation, Faculty of Brain Sciences, Queen Square MS Center, UCL Institute of Neurology, University College London, London, UK (FPC), e-Health Center, Universitat Oberta de Catalunya, Barcelona, Spain (FPC), Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands (FB).