Association of MRI visible Perivascular Spaces with Early White Matter Injury

From the Chobanian & Avedisian School of Medicine, Boston, MA, USA (A.R.T., F.R.L.). NHLBI’s Framingham Heart Study, Framingham, MA, USA (A.P., S.D., S.S, J.R.R.). Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA (A.P, S.D.); Department of Neurology. University of California at Davis, Davis, CA, USA (C.D., P.M); and Department of Radiology Veterans Affairs Boston Health (P.P.). Department of Neurology Chobanian & Avedisian School of Medicine, Boston, MA, USA (A.C., S.S, J.R.R.). From the The Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX 78229, USA (M.H.).

From the Chobanian & Avedisian School of Medicine, Boston, MA, USA (A.R.T., F.R.L.). NHLBI’s Framingham Heart Study, Framingham, MA, USA (A.P., S.D., S.S, J.R.R.). Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA (A.P, S.D.); Department of Neurology. University of California at Davis, Davis, CA, USA (C.D., P.M); and Department of Radiology Veterans Affairs Boston Health (P.P.). Department of Neurology Chobanian & Avedisian School of Medicine, Boston, MA, USA (A.C., S.S, J.R.R.). From the The Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX 78229, USA (M.H.).

From the Chobanian & Avedisian School of Medicine, Boston, MA, USA (A.R.T., F.R.L.). NHLBI’s Framingham Heart Study, Framingham, MA, USA (A.P., S.D., S.S, J.R.R.). Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA (A.P, S.D.); Department of Neurology. University of California at Davis, Davis, CA, USA (C.D., P.M); and Department of Radiology Veterans Affairs Boston Health (P.P.). Department of Neurology Chobanian & Avedisian School of Medicine, Boston, MA, USA (A.C., S.S, J.R.R.). From the The Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX 78229, USA (M.H.).

From the Chobanian & Avedisian School of Medicine, Boston, MA, USA (A.R.T., F.R.L.). NHLBI’s Framingham Heart Study, Framingham, MA, USA (A.P., S.D., S.S, J.R.R.). Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA (A.P, S.D.); Department of Neurology. University of California at Davis, Davis, CA, USA (C.D., P.M); and Department of Radiology Veterans Affairs Boston Health (P.P.). Department of Neurology Chobanian & Avedisian School of Medicine, Boston, MA, USA (A.C., S.S, J.R.R.). From the The Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX 78229, USA (M.H.).

From the Chobanian & Avedisian School of Medicine, Boston, MA, USA (A.R.T., F.R.L.). NHLBI’s Framingham Heart Study, Framingham, MA, USA (A.P., S.D., S.S, J.R.R.). Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA (A.P, S.D.); Department of Neurology. University of California at Davis, Davis, CA, USA (C.D., P.M); and Department of Radiology Veterans Affairs Boston Health (P.P.). Department of Neurology Chobanian & Avedisian School of Medicine, Boston, MA, USA (A.C., S.S, J.R.R.). From the The Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX 78229, USA (M.H.).

From the Chobanian & Avedisian School of Medicine, Boston, MA, USA (A.R.T., F.R.L.). NHLBI’s Framingham Heart Study, Framingham, MA, USA (A.P., S.D., S.S, J.R.R.). Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA (A.P, S.D.); Department of Neurology. University of California at Davis, Davis, CA, USA (C.D., P.M); and Department of Radiology Veterans Affairs Boston Health (P.P.). Department of Neurology Chobanian & Avedisian School of Medicine, Boston, MA, USA (A.C., S.S, J.R.R.). From the The Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX 78229, USA (M.H.).

From the Chobanian & Avedisian School of Medicine, Boston, MA, USA (A.R.T., F.R.L.). NHLBI’s Framingham Heart Study, Framingham, MA, USA (A.P., S.D., S.S, J.R.R.). Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA (A.P, S.D.); Department of Neurology. University of California at Davis, Davis, CA, USA (C.D., P.M); and Department of Radiology Veterans Affairs Boston Health (P.P.). Department of Neurology Chobanian & Avedisian School of Medicine, Boston, MA, USA (A.C., S.S, J.R.R.). From the The Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX 78229, USA (M.H.).

From the Chobanian & Avedisian School of Medicine, Boston, MA, USA (A.R.T., F.R.L.). NHLBI’s Framingham Heart Study, Framingham, MA, USA (A.P., S.D., S.S, J.R.R.). Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA (A.P, S.D.); Department of Neurology. University of California at Davis, Davis, CA, USA (C.D., P.M); and Department of Radiology Veterans Affairs Boston Health (P.P.). Department of Neurology Chobanian & Avedisian School of Medicine, Boston, MA, USA (A.C., S.S, J.R.R.). From the The Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX 78229, USA (M.H.).

From the Chobanian & Avedisian School of Medicine, Boston, MA, USA (A.R.T., F.R.L.). NHLBI’s Framingham Heart Study, Framingham, MA, USA (A.P., S.D., S.S, J.R.R.). Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA (A.P, S.D.); Department of Neurology. University of California at Davis, Davis, CA, USA (C.D., P.M); and Department of Radiology Veterans Affairs Boston Health (P.P.). Department of Neurology Chobanian & Avedisian School of Medicine, Boston, MA, USA (A.C., S.S, J.R.R.). From the The Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX 78229, USA (M.H.).

From the Chobanian & Avedisian School of Medicine, Boston, MA, USA (A.R.T., F.R.L.). NHLBI’s Framingham Heart Study, Framingham, MA, USA (A.P., S.D., S.S, J.R.R.). Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA (A.P, S.D.); Department of Neurology. University of California at Davis, Davis, CA, USA (C.D., P.M); and Department of Radiology Veterans Affairs Boston Health (P.P.). Department of Neurology Chobanian & Avedisian School of Medicine, Boston, MA, USA (A.C., S.S, J.R.R.). From the The Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX 78229, USA (M.H.).

From the Chobanian & Avedisian School of Medicine, Boston, MA, USA (A.R.T., F.R.L.). NHLBI’s Framingham Heart Study, Framingham, MA, USA (A.P., S.D., S.S, J.R.R.). Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA (A.P, S.D.); Department of Neurology. University of California at Davis, Davis, CA, USA (C.D., P.M); and Department of Radiology Veterans Affairs Boston Health (P.P.). Department of Neurology Chobanian & Avedisian School of Medicine, Boston, MA, USA (A.C., S.S, J.R.R.). From the The Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX 78229, USA (M.H.).