Research ArticleORIGINAL RESEARCH
CNS Embryonal Tumor with PLAGL Amplification, a New Tumor Type in Children and Adolescents: Insights from a Comprehensive MRI Analysis
A Tietze, B Bison, European Society for Paediatric Oncology (SIOPE)-Brain Tumour Group, J Engelhardt, T Fenouil, D Figarella-Branger, E Goebell, J Hakumäki, E Koscielniak, LE Ludlow, D Meyronet, P Nyman, I Øra, J Pesola, T Rauramaa, RE Reddingius, D Samuel, A Sexton-Oates, A Vasiljevic, AK Wefers, J Zamecnik, DTW Jones, MK Keck and K von Hoff
American Journal of Neuroradiology September 2024, ajnr.A8496; DOI: https://doi.org/10.3174/ajnr.A8496
A Tietze
From the Inst. of Neuroradiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany (T.A.); Dept. of Neuroradiology, University Hospital Augsburg, Germany (B.B.); Neuroradiological Reference Center for the pediatric brain tumor (HIT) studies of the German Society of Pediatric Oncology and Hematology, Faculty of Medicine, University Augsburg, Augsburg, Germany (B.B.); Service de Neurochirurgie B, CHU de Bordeaux, University of Bourdeaux, France (E.J.); Univ. Bordeaux, Bordeaux INP, CNRS, IMB, UMR 5251, Talence, France (E.J.); Institut de Pathologie Multisite-Site Est, Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France (F.T., M.D., V.A.); Aix- Marseille Univ, APHM, CNRS, INP, Inst Neurophysiopathol, CHU Timone, Service d'Anatomie Pathologique et de Neuropathologie, Marseille, France (FB.D.); Dept. of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (G.E.); Dept. of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland (H.J.); Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (H.J.); Dept. of Pediatric Oncology/Hematology/Immunology, Olgahospital, Klinikum Stuttgart, Stuttgart, Germany (K.E.); Murdoch Children’s Research Inst., The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, Australia (L.LE); Children’s Cancer Centre, The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, 3052, Australia (L.LE); Dept. of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia (L.LE); Crown Princess Victoria Children's Hospital, Linköping University Hospital, Linköping, Sweden (N.P.); Dept. of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden (N.P.); Dept. of Pediatric Oncology and Hematology, Skåne University Hospital, Lund University, Lund, Sweden (Ø.I); Dept. of Pediatrics, Pediatric Hematology and Oncology Ward, Kuopio University Hospital and Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (P.J.); Dept. of Clinical Pathology, Kuopio University Hospital and Unit of Pathology, Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (R.T.); Dept. of Neuro-Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands (R.RE.); Dept. of Hematology-Oncology, Valley Children's Hospital, Madera, CA, USA (S.D.); Rare Cancers Genomics Team, Genomic Epidemiology Branch, International Agency for Research on Cancer/World Health Organization, Lyon, France (S-O.A.); Inst. of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Dept. of Pathology and Molecular Medicine, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic (Z.J.); Division of Pediatric Glioma Research, Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany (J.D.T.W., K.M.K.); Division of Pediatric Glioma Research (B360), German Cancer Research Center (DKFZ), Heidelberg, Germany (J.D.T.W., K.M.K.); National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Germany (J.D.T.W., K.M.K.); Dept. of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Inst. of Health, Berlin, Germany (V.H.K.); Dept. of Paediatric and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark (V.H.K.); (European Society for Paediatric Oncology (SIOPE)-Brain Tumour Group.
B Bison
From the Inst. of Neuroradiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany (T.A.); Dept. of Neuroradiology, University Hospital Augsburg, Germany (B.B.); Neuroradiological Reference Center for the pediatric brain tumor (HIT) studies of the German Society of Pediatric Oncology and Hematology, Faculty of Medicine, University Augsburg, Augsburg, Germany (B.B.); Service de Neurochirurgie B, CHU de Bordeaux, University of Bourdeaux, France (E.J.); Univ. Bordeaux, Bordeaux INP, CNRS, IMB, UMR 5251, Talence, France (E.J.); Institut de Pathologie Multisite-Site Est, Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France (F.T., M.D., V.A.); Aix- Marseille Univ, APHM, CNRS, INP, Inst Neurophysiopathol, CHU Timone, Service d'Anatomie Pathologique et de Neuropathologie, Marseille, France (FB.D.); Dept. of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (G.E.); Dept. of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland (H.J.); Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (H.J.); Dept. of Pediatric Oncology/Hematology/Immunology, Olgahospital, Klinikum Stuttgart, Stuttgart, Germany (K.E.); Murdoch Children’s Research Inst., The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, Australia (L.LE); Children’s Cancer Centre, The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, 3052, Australia (L.LE); Dept. of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia (L.LE); Crown Princess Victoria Children's Hospital, Linköping University Hospital, Linköping, Sweden (N.P.); Dept. of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden (N.P.); Dept. of Pediatric Oncology and Hematology, Skåne University Hospital, Lund University, Lund, Sweden (Ø.I); Dept. of Pediatrics, Pediatric Hematology and Oncology Ward, Kuopio University Hospital and Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (P.J.); Dept. of Clinical Pathology, Kuopio University Hospital and Unit of Pathology, Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (R.T.); Dept. of Neuro-Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands (R.RE.); Dept. of Hematology-Oncology, Valley Children's Hospital, Madera, CA, USA (S.D.); Rare Cancers Genomics Team, Genomic Epidemiology Branch, International Agency for Research on Cancer/World Health Organization, Lyon, France (S-O.A.); Inst. of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Dept. of Pathology and Molecular Medicine, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic (Z.J.); Division of Pediatric Glioma Research, Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany (J.D.T.W., K.M.K.); Division of Pediatric Glioma Research (B360), German Cancer Research Center (DKFZ), Heidelberg, Germany (J.D.T.W., K.M.K.); National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Germany (J.D.T.W., K.M.K.); Dept. of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Inst. of Health, Berlin, Germany (V.H.K.); Dept. of Paediatric and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark (V.H.K.); (European Society for Paediatric Oncology (SIOPE)-Brain Tumour Group.
J Engelhardt
From the Inst. of Neuroradiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany (T.A.); Dept. of Neuroradiology, University Hospital Augsburg, Germany (B.B.); Neuroradiological Reference Center for the pediatric brain tumor (HIT) studies of the German Society of Pediatric Oncology and Hematology, Faculty of Medicine, University Augsburg, Augsburg, Germany (B.B.); Service de Neurochirurgie B, CHU de Bordeaux, University of Bourdeaux, France (E.J.); Univ. Bordeaux, Bordeaux INP, CNRS, IMB, UMR 5251, Talence, France (E.J.); Institut de Pathologie Multisite-Site Est, Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France (F.T., M.D., V.A.); Aix- Marseille Univ, APHM, CNRS, INP, Inst Neurophysiopathol, CHU Timone, Service d'Anatomie Pathologique et de Neuropathologie, Marseille, France (FB.D.); Dept. of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (G.E.); Dept. of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland (H.J.); Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (H.J.); Dept. of Pediatric Oncology/Hematology/Immunology, Olgahospital, Klinikum Stuttgart, Stuttgart, Germany (K.E.); Murdoch Children’s Research Inst., The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, Australia (L.LE); Children’s Cancer Centre, The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, 3052, Australia (L.LE); Dept. of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia (L.LE); Crown Princess Victoria Children's Hospital, Linköping University Hospital, Linköping, Sweden (N.P.); Dept. of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden (N.P.); Dept. of Pediatric Oncology and Hematology, Skåne University Hospital, Lund University, Lund, Sweden (Ø.I); Dept. of Pediatrics, Pediatric Hematology and Oncology Ward, Kuopio University Hospital and Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (P.J.); Dept. of Clinical Pathology, Kuopio University Hospital and Unit of Pathology, Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (R.T.); Dept. of Neuro-Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands (R.RE.); Dept. of Hematology-Oncology, Valley Children's Hospital, Madera, CA, USA (S.D.); Rare Cancers Genomics Team, Genomic Epidemiology Branch, International Agency for Research on Cancer/World Health Organization, Lyon, France (S-O.A.); Inst. of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Dept. of Pathology and Molecular Medicine, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic (Z.J.); Division of Pediatric Glioma Research, Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany (J.D.T.W., K.M.K.); Division of Pediatric Glioma Research (B360), German Cancer Research Center (DKFZ), Heidelberg, Germany (J.D.T.W., K.M.K.); National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Germany (J.D.T.W., K.M.K.); Dept. of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Inst. of Health, Berlin, Germany (V.H.K.); Dept. of Paediatric and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark (V.H.K.); (European Society for Paediatric Oncology (SIOPE)-Brain Tumour Group.
T Fenouil
From the Inst. of Neuroradiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany (T.A.); Dept. of Neuroradiology, University Hospital Augsburg, Germany (B.B.); Neuroradiological Reference Center for the pediatric brain tumor (HIT) studies of the German Society of Pediatric Oncology and Hematology, Faculty of Medicine, University Augsburg, Augsburg, Germany (B.B.); Service de Neurochirurgie B, CHU de Bordeaux, University of Bourdeaux, France (E.J.); Univ. Bordeaux, Bordeaux INP, CNRS, IMB, UMR 5251, Talence, France (E.J.); Institut de Pathologie Multisite-Site Est, Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France (F.T., M.D., V.A.); Aix- Marseille Univ, APHM, CNRS, INP, Inst Neurophysiopathol, CHU Timone, Service d'Anatomie Pathologique et de Neuropathologie, Marseille, France (FB.D.); Dept. of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (G.E.); Dept. of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland (H.J.); Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (H.J.); Dept. of Pediatric Oncology/Hematology/Immunology, Olgahospital, Klinikum Stuttgart, Stuttgart, Germany (K.E.); Murdoch Children’s Research Inst., The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, Australia (L.LE); Children’s Cancer Centre, The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, 3052, Australia (L.LE); Dept. of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia (L.LE); Crown Princess Victoria Children's Hospital, Linköping University Hospital, Linköping, Sweden (N.P.); Dept. of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden (N.P.); Dept. of Pediatric Oncology and Hematology, Skåne University Hospital, Lund University, Lund, Sweden (Ø.I); Dept. of Pediatrics, Pediatric Hematology and Oncology Ward, Kuopio University Hospital and Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (P.J.); Dept. of Clinical Pathology, Kuopio University Hospital and Unit of Pathology, Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (R.T.); Dept. of Neuro-Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands (R.RE.); Dept. of Hematology-Oncology, Valley Children's Hospital, Madera, CA, USA (S.D.); Rare Cancers Genomics Team, Genomic Epidemiology Branch, International Agency for Research on Cancer/World Health Organization, Lyon, France (S-O.A.); Inst. of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Dept. of Pathology and Molecular Medicine, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic (Z.J.); Division of Pediatric Glioma Research, Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany (J.D.T.W., K.M.K.); Division of Pediatric Glioma Research (B360), German Cancer Research Center (DKFZ), Heidelberg, Germany (J.D.T.W., K.M.K.); National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Germany (J.D.T.W., K.M.K.); Dept. of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Inst. of Health, Berlin, Germany (V.H.K.); Dept. of Paediatric and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark (V.H.K.); (European Society for Paediatric Oncology (SIOPE)-Brain Tumour Group.
D Figarella-Branger
From the Inst. of Neuroradiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany (T.A.); Dept. of Neuroradiology, University Hospital Augsburg, Germany (B.B.); Neuroradiological Reference Center for the pediatric brain tumor (HIT) studies of the German Society of Pediatric Oncology and Hematology, Faculty of Medicine, University Augsburg, Augsburg, Germany (B.B.); Service de Neurochirurgie B, CHU de Bordeaux, University of Bourdeaux, France (E.J.); Univ. Bordeaux, Bordeaux INP, CNRS, IMB, UMR 5251, Talence, France (E.J.); Institut de Pathologie Multisite-Site Est, Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France (F.T., M.D., V.A.); Aix- Marseille Univ, APHM, CNRS, INP, Inst Neurophysiopathol, CHU Timone, Service d'Anatomie Pathologique et de Neuropathologie, Marseille, France (FB.D.); Dept. of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (G.E.); Dept. of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland (H.J.); Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (H.J.); Dept. of Pediatric Oncology/Hematology/Immunology, Olgahospital, Klinikum Stuttgart, Stuttgart, Germany (K.E.); Murdoch Children’s Research Inst., The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, Australia (L.LE); Children’s Cancer Centre, The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, 3052, Australia (L.LE); Dept. of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia (L.LE); Crown Princess Victoria Children's Hospital, Linköping University Hospital, Linköping, Sweden (N.P.); Dept. of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden (N.P.); Dept. of Pediatric Oncology and Hematology, Skåne University Hospital, Lund University, Lund, Sweden (Ø.I); Dept. of Pediatrics, Pediatric Hematology and Oncology Ward, Kuopio University Hospital and Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (P.J.); Dept. of Clinical Pathology, Kuopio University Hospital and Unit of Pathology, Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (R.T.); Dept. of Neuro-Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands (R.RE.); Dept. of Hematology-Oncology, Valley Children's Hospital, Madera, CA, USA (S.D.); Rare Cancers Genomics Team, Genomic Epidemiology Branch, International Agency for Research on Cancer/World Health Organization, Lyon, France (S-O.A.); Inst. of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Dept. of Pathology and Molecular Medicine, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic (Z.J.); Division of Pediatric Glioma Research, Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany (J.D.T.W., K.M.K.); Division of Pediatric Glioma Research (B360), German Cancer Research Center (DKFZ), Heidelberg, Germany (J.D.T.W., K.M.K.); National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Germany (J.D.T.W., K.M.K.); Dept. of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Inst. of Health, Berlin, Germany (V.H.K.); Dept. of Paediatric and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark (V.H.K.); (European Society for Paediatric Oncology (SIOPE)-Brain Tumour Group.
E Goebell
From the Inst. of Neuroradiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany (T.A.); Dept. of Neuroradiology, University Hospital Augsburg, Germany (B.B.); Neuroradiological Reference Center for the pediatric brain tumor (HIT) studies of the German Society of Pediatric Oncology and Hematology, Faculty of Medicine, University Augsburg, Augsburg, Germany (B.B.); Service de Neurochirurgie B, CHU de Bordeaux, University of Bourdeaux, France (E.J.); Univ. Bordeaux, Bordeaux INP, CNRS, IMB, UMR 5251, Talence, France (E.J.); Institut de Pathologie Multisite-Site Est, Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France (F.T., M.D., V.A.); Aix- Marseille Univ, APHM, CNRS, INP, Inst Neurophysiopathol, CHU Timone, Service d'Anatomie Pathologique et de Neuropathologie, Marseille, France (FB.D.); Dept. of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (G.E.); Dept. of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland (H.J.); Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (H.J.); Dept. of Pediatric Oncology/Hematology/Immunology, Olgahospital, Klinikum Stuttgart, Stuttgart, Germany (K.E.); Murdoch Children’s Research Inst., The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, Australia (L.LE); Children’s Cancer Centre, The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, 3052, Australia (L.LE); Dept. of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia (L.LE); Crown Princess Victoria Children's Hospital, Linköping University Hospital, Linköping, Sweden (N.P.); Dept. of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden (N.P.); Dept. of Pediatric Oncology and Hematology, Skåne University Hospital, Lund University, Lund, Sweden (Ø.I); Dept. of Pediatrics, Pediatric Hematology and Oncology Ward, Kuopio University Hospital and Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (P.J.); Dept. of Clinical Pathology, Kuopio University Hospital and Unit of Pathology, Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (R.T.); Dept. of Neuro-Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands (R.RE.); Dept. of Hematology-Oncology, Valley Children's Hospital, Madera, CA, USA (S.D.); Rare Cancers Genomics Team, Genomic Epidemiology Branch, International Agency for Research on Cancer/World Health Organization, Lyon, France (S-O.A.); Inst. of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Dept. of Pathology and Molecular Medicine, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic (Z.J.); Division of Pediatric Glioma Research, Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany (J.D.T.W., K.M.K.); Division of Pediatric Glioma Research (B360), German Cancer Research Center (DKFZ), Heidelberg, Germany (J.D.T.W., K.M.K.); National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Germany (J.D.T.W., K.M.K.); Dept. of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Inst. of Health, Berlin, Germany (V.H.K.); Dept. of Paediatric and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark (V.H.K.); (European Society for Paediatric Oncology (SIOPE)-Brain Tumour Group.
J Hakumäki
From the Inst. of Neuroradiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany (T.A.); Dept. of Neuroradiology, University Hospital Augsburg, Germany (B.B.); Neuroradiological Reference Center for the pediatric brain tumor (HIT) studies of the German Society of Pediatric Oncology and Hematology, Faculty of Medicine, University Augsburg, Augsburg, Germany (B.B.); Service de Neurochirurgie B, CHU de Bordeaux, University of Bourdeaux, France (E.J.); Univ. Bordeaux, Bordeaux INP, CNRS, IMB, UMR 5251, Talence, France (E.J.); Institut de Pathologie Multisite-Site Est, Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France (F.T., M.D., V.A.); Aix- Marseille Univ, APHM, CNRS, INP, Inst Neurophysiopathol, CHU Timone, Service d'Anatomie Pathologique et de Neuropathologie, Marseille, France (FB.D.); Dept. of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (G.E.); Dept. of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland (H.J.); Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (H.J.); Dept. of Pediatric Oncology/Hematology/Immunology, Olgahospital, Klinikum Stuttgart, Stuttgart, Germany (K.E.); Murdoch Children’s Research Inst., The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, Australia (L.LE); Children’s Cancer Centre, The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, 3052, Australia (L.LE); Dept. of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia (L.LE); Crown Princess Victoria Children's Hospital, Linköping University Hospital, Linköping, Sweden (N.P.); Dept. of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden (N.P.); Dept. of Pediatric Oncology and Hematology, Skåne University Hospital, Lund University, Lund, Sweden (Ø.I); Dept. of Pediatrics, Pediatric Hematology and Oncology Ward, Kuopio University Hospital and Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (P.J.); Dept. of Clinical Pathology, Kuopio University Hospital and Unit of Pathology, Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (R.T.); Dept. of Neuro-Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands (R.RE.); Dept. of Hematology-Oncology, Valley Children's Hospital, Madera, CA, USA (S.D.); Rare Cancers Genomics Team, Genomic Epidemiology Branch, International Agency for Research on Cancer/World Health Organization, Lyon, France (S-O.A.); Inst. of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Dept. of Pathology and Molecular Medicine, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic (Z.J.); Division of Pediatric Glioma Research, Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany (J.D.T.W., K.M.K.); Division of Pediatric Glioma Research (B360), German Cancer Research Center (DKFZ), Heidelberg, Germany (J.D.T.W., K.M.K.); National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Germany (J.D.T.W., K.M.K.); Dept. of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Inst. of Health, Berlin, Germany (V.H.K.); Dept. of Paediatric and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark (V.H.K.); (European Society for Paediatric Oncology (SIOPE)-Brain Tumour Group.
E Koscielniak
From the Inst. of Neuroradiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany (T.A.); Dept. of Neuroradiology, University Hospital Augsburg, Germany (B.B.); Neuroradiological Reference Center for the pediatric brain tumor (HIT) studies of the German Society of Pediatric Oncology and Hematology, Faculty of Medicine, University Augsburg, Augsburg, Germany (B.B.); Service de Neurochirurgie B, CHU de Bordeaux, University of Bourdeaux, France (E.J.); Univ. Bordeaux, Bordeaux INP, CNRS, IMB, UMR 5251, Talence, France (E.J.); Institut de Pathologie Multisite-Site Est, Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France (F.T., M.D., V.A.); Aix- Marseille Univ, APHM, CNRS, INP, Inst Neurophysiopathol, CHU Timone, Service d'Anatomie Pathologique et de Neuropathologie, Marseille, France (FB.D.); Dept. of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (G.E.); Dept. of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland (H.J.); Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (H.J.); Dept. of Pediatric Oncology/Hematology/Immunology, Olgahospital, Klinikum Stuttgart, Stuttgart, Germany (K.E.); Murdoch Children’s Research Inst., The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, Australia (L.LE); Children’s Cancer Centre, The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, 3052, Australia (L.LE); Dept. of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia (L.LE); Crown Princess Victoria Children's Hospital, Linköping University Hospital, Linköping, Sweden (N.P.); Dept. of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden (N.P.); Dept. of Pediatric Oncology and Hematology, Skåne University Hospital, Lund University, Lund, Sweden (Ø.I); Dept. of Pediatrics, Pediatric Hematology and Oncology Ward, Kuopio University Hospital and Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (P.J.); Dept. of Clinical Pathology, Kuopio University Hospital and Unit of Pathology, Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (R.T.); Dept. of Neuro-Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands (R.RE.); Dept. of Hematology-Oncology, Valley Children's Hospital, Madera, CA, USA (S.D.); Rare Cancers Genomics Team, Genomic Epidemiology Branch, International Agency for Research on Cancer/World Health Organization, Lyon, France (S-O.A.); Inst. of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Dept. of Pathology and Molecular Medicine, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic (Z.J.); Division of Pediatric Glioma Research, Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany (J.D.T.W., K.M.K.); Division of Pediatric Glioma Research (B360), German Cancer Research Center (DKFZ), Heidelberg, Germany (J.D.T.W., K.M.K.); National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Germany (J.D.T.W., K.M.K.); Dept. of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Inst. of Health, Berlin, Germany (V.H.K.); Dept. of Paediatric and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark (V.H.K.); (European Society for Paediatric Oncology (SIOPE)-Brain Tumour Group.
LE Ludlow
From the Inst. of Neuroradiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany (T.A.); Dept. of Neuroradiology, University Hospital Augsburg, Germany (B.B.); Neuroradiological Reference Center for the pediatric brain tumor (HIT) studies of the German Society of Pediatric Oncology and Hematology, Faculty of Medicine, University Augsburg, Augsburg, Germany (B.B.); Service de Neurochirurgie B, CHU de Bordeaux, University of Bourdeaux, France (E.J.); Univ. Bordeaux, Bordeaux INP, CNRS, IMB, UMR 5251, Talence, France (E.J.); Institut de Pathologie Multisite-Site Est, Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France (F.T., M.D., V.A.); Aix- Marseille Univ, APHM, CNRS, INP, Inst Neurophysiopathol, CHU Timone, Service d'Anatomie Pathologique et de Neuropathologie, Marseille, France (FB.D.); Dept. of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (G.E.); Dept. of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland (H.J.); Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (H.J.); Dept. of Pediatric Oncology/Hematology/Immunology, Olgahospital, Klinikum Stuttgart, Stuttgart, Germany (K.E.); Murdoch Children’s Research Inst., The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, Australia (L.LE); Children’s Cancer Centre, The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, 3052, Australia (L.LE); Dept. of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia (L.LE); Crown Princess Victoria Children's Hospital, Linköping University Hospital, Linköping, Sweden (N.P.); Dept. of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden (N.P.); Dept. of Pediatric Oncology and Hematology, Skåne University Hospital, Lund University, Lund, Sweden (Ø.I); Dept. of Pediatrics, Pediatric Hematology and Oncology Ward, Kuopio University Hospital and Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (P.J.); Dept. of Clinical Pathology, Kuopio University Hospital and Unit of Pathology, Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (R.T.); Dept. of Neuro-Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands (R.RE.); Dept. of Hematology-Oncology, Valley Children's Hospital, Madera, CA, USA (S.D.); Rare Cancers Genomics Team, Genomic Epidemiology Branch, International Agency for Research on Cancer/World Health Organization, Lyon, France (S-O.A.); Inst. of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Dept. of Pathology and Molecular Medicine, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic (Z.J.); Division of Pediatric Glioma Research, Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany (J.D.T.W., K.M.K.); Division of Pediatric Glioma Research (B360), German Cancer Research Center (DKFZ), Heidelberg, Germany (J.D.T.W., K.M.K.); National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Germany (J.D.T.W., K.M.K.); Dept. of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Inst. of Health, Berlin, Germany (V.H.K.); Dept. of Paediatric and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark (V.H.K.); (European Society for Paediatric Oncology (SIOPE)-Brain Tumour Group.
D Meyronet
From the Inst. of Neuroradiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany (T.A.); Dept. of Neuroradiology, University Hospital Augsburg, Germany (B.B.); Neuroradiological Reference Center for the pediatric brain tumor (HIT) studies of the German Society of Pediatric Oncology and Hematology, Faculty of Medicine, University Augsburg, Augsburg, Germany (B.B.); Service de Neurochirurgie B, CHU de Bordeaux, University of Bourdeaux, France (E.J.); Univ. Bordeaux, Bordeaux INP, CNRS, IMB, UMR 5251, Talence, France (E.J.); Institut de Pathologie Multisite-Site Est, Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France (F.T., M.D., V.A.); Aix- Marseille Univ, APHM, CNRS, INP, Inst Neurophysiopathol, CHU Timone, Service d'Anatomie Pathologique et de Neuropathologie, Marseille, France (FB.D.); Dept. of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (G.E.); Dept. of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland (H.J.); Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (H.J.); Dept. of Pediatric Oncology/Hematology/Immunology, Olgahospital, Klinikum Stuttgart, Stuttgart, Germany (K.E.); Murdoch Children’s Research Inst., The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, Australia (L.LE); Children’s Cancer Centre, The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, 3052, Australia (L.LE); Dept. of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia (L.LE); Crown Princess Victoria Children's Hospital, Linköping University Hospital, Linköping, Sweden (N.P.); Dept. of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden (N.P.); Dept. of Pediatric Oncology and Hematology, Skåne University Hospital, Lund University, Lund, Sweden (Ø.I); Dept. of Pediatrics, Pediatric Hematology and Oncology Ward, Kuopio University Hospital and Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (P.J.); Dept. of Clinical Pathology, Kuopio University Hospital and Unit of Pathology, Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (R.T.); Dept. of Neuro-Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands (R.RE.); Dept. of Hematology-Oncology, Valley Children's Hospital, Madera, CA, USA (S.D.); Rare Cancers Genomics Team, Genomic Epidemiology Branch, International Agency for Research on Cancer/World Health Organization, Lyon, France (S-O.A.); Inst. of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Dept. of Pathology and Molecular Medicine, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic (Z.J.); Division of Pediatric Glioma Research, Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany (J.D.T.W., K.M.K.); Division of Pediatric Glioma Research (B360), German Cancer Research Center (DKFZ), Heidelberg, Germany (J.D.T.W., K.M.K.); National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Germany (J.D.T.W., K.M.K.); Dept. of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Inst. of Health, Berlin, Germany (V.H.K.); Dept. of Paediatric and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark (V.H.K.); (European Society for Paediatric Oncology (SIOPE)-Brain Tumour Group.
P Nyman
From the Inst. of Neuroradiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany (T.A.); Dept. of Neuroradiology, University Hospital Augsburg, Germany (B.B.); Neuroradiological Reference Center for the pediatric brain tumor (HIT) studies of the German Society of Pediatric Oncology and Hematology, Faculty of Medicine, University Augsburg, Augsburg, Germany (B.B.); Service de Neurochirurgie B, CHU de Bordeaux, University of Bourdeaux, France (E.J.); Univ. Bordeaux, Bordeaux INP, CNRS, IMB, UMR 5251, Talence, France (E.J.); Institut de Pathologie Multisite-Site Est, Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France (F.T., M.D., V.A.); Aix- Marseille Univ, APHM, CNRS, INP, Inst Neurophysiopathol, CHU Timone, Service d'Anatomie Pathologique et de Neuropathologie, Marseille, France (FB.D.); Dept. of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (G.E.); Dept. of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland (H.J.); Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (H.J.); Dept. of Pediatric Oncology/Hematology/Immunology, Olgahospital, Klinikum Stuttgart, Stuttgart, Germany (K.E.); Murdoch Children’s Research Inst., The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, Australia (L.LE); Children’s Cancer Centre, The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, 3052, Australia (L.LE); Dept. of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia (L.LE); Crown Princess Victoria Children's Hospital, Linköping University Hospital, Linköping, Sweden (N.P.); Dept. of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden (N.P.); Dept. of Pediatric Oncology and Hematology, Skåne University Hospital, Lund University, Lund, Sweden (Ø.I); Dept. of Pediatrics, Pediatric Hematology and Oncology Ward, Kuopio University Hospital and Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (P.J.); Dept. of Clinical Pathology, Kuopio University Hospital and Unit of Pathology, Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (R.T.); Dept. of Neuro-Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands (R.RE.); Dept. of Hematology-Oncology, Valley Children's Hospital, Madera, CA, USA (S.D.); Rare Cancers Genomics Team, Genomic Epidemiology Branch, International Agency for Research on Cancer/World Health Organization, Lyon, France (S-O.A.); Inst. of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Dept. of Pathology and Molecular Medicine, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic (Z.J.); Division of Pediatric Glioma Research, Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany (J.D.T.W., K.M.K.); Division of Pediatric Glioma Research (B360), German Cancer Research Center (DKFZ), Heidelberg, Germany (J.D.T.W., K.M.K.); National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Germany (J.D.T.W., K.M.K.); Dept. of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Inst. of Health, Berlin, Germany (V.H.K.); Dept. of Paediatric and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark (V.H.K.); (European Society for Paediatric Oncology (SIOPE)-Brain Tumour Group.
I Øra
From the Inst. of Neuroradiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany (T.A.); Dept. of Neuroradiology, University Hospital Augsburg, Germany (B.B.); Neuroradiological Reference Center for the pediatric brain tumor (HIT) studies of the German Society of Pediatric Oncology and Hematology, Faculty of Medicine, University Augsburg, Augsburg, Germany (B.B.); Service de Neurochirurgie B, CHU de Bordeaux, University of Bourdeaux, France (E.J.); Univ. Bordeaux, Bordeaux INP, CNRS, IMB, UMR 5251, Talence, France (E.J.); Institut de Pathologie Multisite-Site Est, Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France (F.T., M.D., V.A.); Aix- Marseille Univ, APHM, CNRS, INP, Inst Neurophysiopathol, CHU Timone, Service d'Anatomie Pathologique et de Neuropathologie, Marseille, France (FB.D.); Dept. of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (G.E.); Dept. of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland (H.J.); Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (H.J.); Dept. of Pediatric Oncology/Hematology/Immunology, Olgahospital, Klinikum Stuttgart, Stuttgart, Germany (K.E.); Murdoch Children’s Research Inst., The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, Australia (L.LE); Children’s Cancer Centre, The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, 3052, Australia (L.LE); Dept. of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia (L.LE); Crown Princess Victoria Children's Hospital, Linköping University Hospital, Linköping, Sweden (N.P.); Dept. of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden (N.P.); Dept. of Pediatric Oncology and Hematology, Skåne University Hospital, Lund University, Lund, Sweden (Ø.I); Dept. of Pediatrics, Pediatric Hematology and Oncology Ward, Kuopio University Hospital and Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (P.J.); Dept. of Clinical Pathology, Kuopio University Hospital and Unit of Pathology, Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (R.T.); Dept. of Neuro-Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands (R.RE.); Dept. of Hematology-Oncology, Valley Children's Hospital, Madera, CA, USA (S.D.); Rare Cancers Genomics Team, Genomic Epidemiology Branch, International Agency for Research on Cancer/World Health Organization, Lyon, France (S-O.A.); Inst. of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Dept. of Pathology and Molecular Medicine, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic (Z.J.); Division of Pediatric Glioma Research, Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany (J.D.T.W., K.M.K.); Division of Pediatric Glioma Research (B360), German Cancer Research Center (DKFZ), Heidelberg, Germany (J.D.T.W., K.M.K.); National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Germany (J.D.T.W., K.M.K.); Dept. of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Inst. of Health, Berlin, Germany (V.H.K.); Dept. of Paediatric and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark (V.H.K.); (European Society for Paediatric Oncology (SIOPE)-Brain Tumour Group.
J Pesola
From the Inst. of Neuroradiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany (T.A.); Dept. of Neuroradiology, University Hospital Augsburg, Germany (B.B.); Neuroradiological Reference Center for the pediatric brain tumor (HIT) studies of the German Society of Pediatric Oncology and Hematology, Faculty of Medicine, University Augsburg, Augsburg, Germany (B.B.); Service de Neurochirurgie B, CHU de Bordeaux, University of Bourdeaux, France (E.J.); Univ. Bordeaux, Bordeaux INP, CNRS, IMB, UMR 5251, Talence, France (E.J.); Institut de Pathologie Multisite-Site Est, Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France (F.T., M.D., V.A.); Aix- Marseille Univ, APHM, CNRS, INP, Inst Neurophysiopathol, CHU Timone, Service d'Anatomie Pathologique et de Neuropathologie, Marseille, France (FB.D.); Dept. of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (G.E.); Dept. of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland (H.J.); Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (H.J.); Dept. of Pediatric Oncology/Hematology/Immunology, Olgahospital, Klinikum Stuttgart, Stuttgart, Germany (K.E.); Murdoch Children’s Research Inst., The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, Australia (L.LE); Children’s Cancer Centre, The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, 3052, Australia (L.LE); Dept. of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia (L.LE); Crown Princess Victoria Children's Hospital, Linköping University Hospital, Linköping, Sweden (N.P.); Dept. of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden (N.P.); Dept. of Pediatric Oncology and Hematology, Skåne University Hospital, Lund University, Lund, Sweden (Ø.I); Dept. of Pediatrics, Pediatric Hematology and Oncology Ward, Kuopio University Hospital and Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (P.J.); Dept. of Clinical Pathology, Kuopio University Hospital and Unit of Pathology, Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (R.T.); Dept. of Neuro-Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands (R.RE.); Dept. of Hematology-Oncology, Valley Children's Hospital, Madera, CA, USA (S.D.); Rare Cancers Genomics Team, Genomic Epidemiology Branch, International Agency for Research on Cancer/World Health Organization, Lyon, France (S-O.A.); Inst. of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Dept. of Pathology and Molecular Medicine, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic (Z.J.); Division of Pediatric Glioma Research, Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany (J.D.T.W., K.M.K.); Division of Pediatric Glioma Research (B360), German Cancer Research Center (DKFZ), Heidelberg, Germany (J.D.T.W., K.M.K.); National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Germany (J.D.T.W., K.M.K.); Dept. of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Inst. of Health, Berlin, Germany (V.H.K.); Dept. of Paediatric and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark (V.H.K.); (European Society for Paediatric Oncology (SIOPE)-Brain Tumour Group.
T Rauramaa
From the Inst. of Neuroradiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany (T.A.); Dept. of Neuroradiology, University Hospital Augsburg, Germany (B.B.); Neuroradiological Reference Center for the pediatric brain tumor (HIT) studies of the German Society of Pediatric Oncology and Hematology, Faculty of Medicine, University Augsburg, Augsburg, Germany (B.B.); Service de Neurochirurgie B, CHU de Bordeaux, University of Bourdeaux, France (E.J.); Univ. Bordeaux, Bordeaux INP, CNRS, IMB, UMR 5251, Talence, France (E.J.); Institut de Pathologie Multisite-Site Est, Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France (F.T., M.D., V.A.); Aix- Marseille Univ, APHM, CNRS, INP, Inst Neurophysiopathol, CHU Timone, Service d'Anatomie Pathologique et de Neuropathologie, Marseille, France (FB.D.); Dept. of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (G.E.); Dept. of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland (H.J.); Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (H.J.); Dept. of Pediatric Oncology/Hematology/Immunology, Olgahospital, Klinikum Stuttgart, Stuttgart, Germany (K.E.); Murdoch Children’s Research Inst., The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, Australia (L.LE); Children’s Cancer Centre, The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, 3052, Australia (L.LE); Dept. of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia (L.LE); Crown Princess Victoria Children's Hospital, Linköping University Hospital, Linköping, Sweden (N.P.); Dept. of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden (N.P.); Dept. of Pediatric Oncology and Hematology, Skåne University Hospital, Lund University, Lund, Sweden (Ø.I); Dept. of Pediatrics, Pediatric Hematology and Oncology Ward, Kuopio University Hospital and Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (P.J.); Dept. of Clinical Pathology, Kuopio University Hospital and Unit of Pathology, Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (R.T.); Dept. of Neuro-Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands (R.RE.); Dept. of Hematology-Oncology, Valley Children's Hospital, Madera, CA, USA (S.D.); Rare Cancers Genomics Team, Genomic Epidemiology Branch, International Agency for Research on Cancer/World Health Organization, Lyon, France (S-O.A.); Inst. of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Dept. of Pathology and Molecular Medicine, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic (Z.J.); Division of Pediatric Glioma Research, Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany (J.D.T.W., K.M.K.); Division of Pediatric Glioma Research (B360), German Cancer Research Center (DKFZ), Heidelberg, Germany (J.D.T.W., K.M.K.); National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Germany (J.D.T.W., K.M.K.); Dept. of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Inst. of Health, Berlin, Germany (V.H.K.); Dept. of Paediatric and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark (V.H.K.); (European Society for Paediatric Oncology (SIOPE)-Brain Tumour Group.
RE Reddingius
From the Inst. of Neuroradiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany (T.A.); Dept. of Neuroradiology, University Hospital Augsburg, Germany (B.B.); Neuroradiological Reference Center for the pediatric brain tumor (HIT) studies of the German Society of Pediatric Oncology and Hematology, Faculty of Medicine, University Augsburg, Augsburg, Germany (B.B.); Service de Neurochirurgie B, CHU de Bordeaux, University of Bourdeaux, France (E.J.); Univ. Bordeaux, Bordeaux INP, CNRS, IMB, UMR 5251, Talence, France (E.J.); Institut de Pathologie Multisite-Site Est, Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France (F.T., M.D., V.A.); Aix- Marseille Univ, APHM, CNRS, INP, Inst Neurophysiopathol, CHU Timone, Service d'Anatomie Pathologique et de Neuropathologie, Marseille, France (FB.D.); Dept. of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (G.E.); Dept. of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland (H.J.); Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (H.J.); Dept. of Pediatric Oncology/Hematology/Immunology, Olgahospital, Klinikum Stuttgart, Stuttgart, Germany (K.E.); Murdoch Children’s Research Inst., The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, Australia (L.LE); Children’s Cancer Centre, The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, 3052, Australia (L.LE); Dept. of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia (L.LE); Crown Princess Victoria Children's Hospital, Linköping University Hospital, Linköping, Sweden (N.P.); Dept. of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden (N.P.); Dept. of Pediatric Oncology and Hematology, Skåne University Hospital, Lund University, Lund, Sweden (Ø.I); Dept. of Pediatrics, Pediatric Hematology and Oncology Ward, Kuopio University Hospital and Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (P.J.); Dept. of Clinical Pathology, Kuopio University Hospital and Unit of Pathology, Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (R.T.); Dept. of Neuro-Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands (R.RE.); Dept. of Hematology-Oncology, Valley Children's Hospital, Madera, CA, USA (S.D.); Rare Cancers Genomics Team, Genomic Epidemiology Branch, International Agency for Research on Cancer/World Health Organization, Lyon, France (S-O.A.); Inst. of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Dept. of Pathology and Molecular Medicine, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic (Z.J.); Division of Pediatric Glioma Research, Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany (J.D.T.W., K.M.K.); Division of Pediatric Glioma Research (B360), German Cancer Research Center (DKFZ), Heidelberg, Germany (J.D.T.W., K.M.K.); National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Germany (J.D.T.W., K.M.K.); Dept. of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Inst. of Health, Berlin, Germany (V.H.K.); Dept. of Paediatric and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark (V.H.K.); (European Society for Paediatric Oncology (SIOPE)-Brain Tumour Group.
D Samuel
From the Inst. of Neuroradiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany (T.A.); Dept. of Neuroradiology, University Hospital Augsburg, Germany (B.B.); Neuroradiological Reference Center for the pediatric brain tumor (HIT) studies of the German Society of Pediatric Oncology and Hematology, Faculty of Medicine, University Augsburg, Augsburg, Germany (B.B.); Service de Neurochirurgie B, CHU de Bordeaux, University of Bourdeaux, France (E.J.); Univ. Bordeaux, Bordeaux INP, CNRS, IMB, UMR 5251, Talence, France (E.J.); Institut de Pathologie Multisite-Site Est, Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France (F.T., M.D., V.A.); Aix- Marseille Univ, APHM, CNRS, INP, Inst Neurophysiopathol, CHU Timone, Service d'Anatomie Pathologique et de Neuropathologie, Marseille, France (FB.D.); Dept. of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (G.E.); Dept. of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland (H.J.); Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (H.J.); Dept. of Pediatric Oncology/Hematology/Immunology, Olgahospital, Klinikum Stuttgart, Stuttgart, Germany (K.E.); Murdoch Children’s Research Inst., The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, Australia (L.LE); Children’s Cancer Centre, The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, 3052, Australia (L.LE); Dept. of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia (L.LE); Crown Princess Victoria Children's Hospital, Linköping University Hospital, Linköping, Sweden (N.P.); Dept. of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden (N.P.); Dept. of Pediatric Oncology and Hematology, Skåne University Hospital, Lund University, Lund, Sweden (Ø.I); Dept. of Pediatrics, Pediatric Hematology and Oncology Ward, Kuopio University Hospital and Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (P.J.); Dept. of Clinical Pathology, Kuopio University Hospital and Unit of Pathology, Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (R.T.); Dept. of Neuro-Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands (R.RE.); Dept. of Hematology-Oncology, Valley Children's Hospital, Madera, CA, USA (S.D.); Rare Cancers Genomics Team, Genomic Epidemiology Branch, International Agency for Research on Cancer/World Health Organization, Lyon, France (S-O.A.); Inst. of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Dept. of Pathology and Molecular Medicine, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic (Z.J.); Division of Pediatric Glioma Research, Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany (J.D.T.W., K.M.K.); Division of Pediatric Glioma Research (B360), German Cancer Research Center (DKFZ), Heidelberg, Germany (J.D.T.W., K.M.K.); National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Germany (J.D.T.W., K.M.K.); Dept. of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Inst. of Health, Berlin, Germany (V.H.K.); Dept. of Paediatric and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark (V.H.K.); (European Society for Paediatric Oncology (SIOPE)-Brain Tumour Group.
A Sexton-Oates
From the Inst. of Neuroradiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany (T.A.); Dept. of Neuroradiology, University Hospital Augsburg, Germany (B.B.); Neuroradiological Reference Center for the pediatric brain tumor (HIT) studies of the German Society of Pediatric Oncology and Hematology, Faculty of Medicine, University Augsburg, Augsburg, Germany (B.B.); Service de Neurochirurgie B, CHU de Bordeaux, University of Bourdeaux, France (E.J.); Univ. Bordeaux, Bordeaux INP, CNRS, IMB, UMR 5251, Talence, France (E.J.); Institut de Pathologie Multisite-Site Est, Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France (F.T., M.D., V.A.); Aix- Marseille Univ, APHM, CNRS, INP, Inst Neurophysiopathol, CHU Timone, Service d'Anatomie Pathologique et de Neuropathologie, Marseille, France (FB.D.); Dept. of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (G.E.); Dept. of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland (H.J.); Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (H.J.); Dept. of Pediatric Oncology/Hematology/Immunology, Olgahospital, Klinikum Stuttgart, Stuttgart, Germany (K.E.); Murdoch Children’s Research Inst., The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, Australia (L.LE); Children’s Cancer Centre, The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, 3052, Australia (L.LE); Dept. of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia (L.LE); Crown Princess Victoria Children's Hospital, Linköping University Hospital, Linköping, Sweden (N.P.); Dept. of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden (N.P.); Dept. of Pediatric Oncology and Hematology, Skåne University Hospital, Lund University, Lund, Sweden (Ø.I); Dept. of Pediatrics, Pediatric Hematology and Oncology Ward, Kuopio University Hospital and Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (P.J.); Dept. of Clinical Pathology, Kuopio University Hospital and Unit of Pathology, Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (R.T.); Dept. of Neuro-Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands (R.RE.); Dept. of Hematology-Oncology, Valley Children's Hospital, Madera, CA, USA (S.D.); Rare Cancers Genomics Team, Genomic Epidemiology Branch, International Agency for Research on Cancer/World Health Organization, Lyon, France (S-O.A.); Inst. of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Dept. of Pathology and Molecular Medicine, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic (Z.J.); Division of Pediatric Glioma Research, Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany (J.D.T.W., K.M.K.); Division of Pediatric Glioma Research (B360), German Cancer Research Center (DKFZ), Heidelberg, Germany (J.D.T.W., K.M.K.); National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Germany (J.D.T.W., K.M.K.); Dept. of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Inst. of Health, Berlin, Germany (V.H.K.); Dept. of Paediatric and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark (V.H.K.); (European Society for Paediatric Oncology (SIOPE)-Brain Tumour Group.
A Vasiljevic
From the Inst. of Neuroradiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany (T.A.); Dept. of Neuroradiology, University Hospital Augsburg, Germany (B.B.); Neuroradiological Reference Center for the pediatric brain tumor (HIT) studies of the German Society of Pediatric Oncology and Hematology, Faculty of Medicine, University Augsburg, Augsburg, Germany (B.B.); Service de Neurochirurgie B, CHU de Bordeaux, University of Bourdeaux, France (E.J.); Univ. Bordeaux, Bordeaux INP, CNRS, IMB, UMR 5251, Talence, France (E.J.); Institut de Pathologie Multisite-Site Est, Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France (F.T., M.D., V.A.); Aix- Marseille Univ, APHM, CNRS, INP, Inst Neurophysiopathol, CHU Timone, Service d'Anatomie Pathologique et de Neuropathologie, Marseille, France (FB.D.); Dept. of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (G.E.); Dept. of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland (H.J.); Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (H.J.); Dept. of Pediatric Oncology/Hematology/Immunology, Olgahospital, Klinikum Stuttgart, Stuttgart, Germany (K.E.); Murdoch Children’s Research Inst., The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, Australia (L.LE); Children’s Cancer Centre, The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, 3052, Australia (L.LE); Dept. of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia (L.LE); Crown Princess Victoria Children's Hospital, Linköping University Hospital, Linköping, Sweden (N.P.); Dept. of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden (N.P.); Dept. of Pediatric Oncology and Hematology, Skåne University Hospital, Lund University, Lund, Sweden (Ø.I); Dept. of Pediatrics, Pediatric Hematology and Oncology Ward, Kuopio University Hospital and Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (P.J.); Dept. of Clinical Pathology, Kuopio University Hospital and Unit of Pathology, Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (R.T.); Dept. of Neuro-Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands (R.RE.); Dept. of Hematology-Oncology, Valley Children's Hospital, Madera, CA, USA (S.D.); Rare Cancers Genomics Team, Genomic Epidemiology Branch, International Agency for Research on Cancer/World Health Organization, Lyon, France (S-O.A.); Inst. of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Dept. of Pathology and Molecular Medicine, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic (Z.J.); Division of Pediatric Glioma Research, Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany (J.D.T.W., K.M.K.); Division of Pediatric Glioma Research (B360), German Cancer Research Center (DKFZ), Heidelberg, Germany (J.D.T.W., K.M.K.); National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Germany (J.D.T.W., K.M.K.); Dept. of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Inst. of Health, Berlin, Germany (V.H.K.); Dept. of Paediatric and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark (V.H.K.); (European Society for Paediatric Oncology (SIOPE)-Brain Tumour Group.
AK Wefers
From the Inst. of Neuroradiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany (T.A.); Dept. of Neuroradiology, University Hospital Augsburg, Germany (B.B.); Neuroradiological Reference Center for the pediatric brain tumor (HIT) studies of the German Society of Pediatric Oncology and Hematology, Faculty of Medicine, University Augsburg, Augsburg, Germany (B.B.); Service de Neurochirurgie B, CHU de Bordeaux, University of Bourdeaux, France (E.J.); Univ. Bordeaux, Bordeaux INP, CNRS, IMB, UMR 5251, Talence, France (E.J.); Institut de Pathologie Multisite-Site Est, Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France (F.T., M.D., V.A.); Aix- Marseille Univ, APHM, CNRS, INP, Inst Neurophysiopathol, CHU Timone, Service d'Anatomie Pathologique et de Neuropathologie, Marseille, France (FB.D.); Dept. of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (G.E.); Dept. of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland (H.J.); Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (H.J.); Dept. of Pediatric Oncology/Hematology/Immunology, Olgahospital, Klinikum Stuttgart, Stuttgart, Germany (K.E.); Murdoch Children’s Research Inst., The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, Australia (L.LE); Children’s Cancer Centre, The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, 3052, Australia (L.LE); Dept. of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia (L.LE); Crown Princess Victoria Children's Hospital, Linköping University Hospital, Linköping, Sweden (N.P.); Dept. of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden (N.P.); Dept. of Pediatric Oncology and Hematology, Skåne University Hospital, Lund University, Lund, Sweden (Ø.I); Dept. of Pediatrics, Pediatric Hematology and Oncology Ward, Kuopio University Hospital and Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (P.J.); Dept. of Clinical Pathology, Kuopio University Hospital and Unit of Pathology, Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (R.T.); Dept. of Neuro-Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands (R.RE.); Dept. of Hematology-Oncology, Valley Children's Hospital, Madera, CA, USA (S.D.); Rare Cancers Genomics Team, Genomic Epidemiology Branch, International Agency for Research on Cancer/World Health Organization, Lyon, France (S-O.A.); Inst. of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Dept. of Pathology and Molecular Medicine, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic (Z.J.); Division of Pediatric Glioma Research, Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany (J.D.T.W., K.M.K.); Division of Pediatric Glioma Research (B360), German Cancer Research Center (DKFZ), Heidelberg, Germany (J.D.T.W., K.M.K.); National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Germany (J.D.T.W., K.M.K.); Dept. of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Inst. of Health, Berlin, Germany (V.H.K.); Dept. of Paediatric and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark (V.H.K.); (European Society for Paediatric Oncology (SIOPE)-Brain Tumour Group.
J Zamecnik
From the Inst. of Neuroradiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany (T.A.); Dept. of Neuroradiology, University Hospital Augsburg, Germany (B.B.); Neuroradiological Reference Center for the pediatric brain tumor (HIT) studies of the German Society of Pediatric Oncology and Hematology, Faculty of Medicine, University Augsburg, Augsburg, Germany (B.B.); Service de Neurochirurgie B, CHU de Bordeaux, University of Bourdeaux, France (E.J.); Univ. Bordeaux, Bordeaux INP, CNRS, IMB, UMR 5251, Talence, France (E.J.); Institut de Pathologie Multisite-Site Est, Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France (F.T., M.D., V.A.); Aix- Marseille Univ, APHM, CNRS, INP, Inst Neurophysiopathol, CHU Timone, Service d'Anatomie Pathologique et de Neuropathologie, Marseille, France (FB.D.); Dept. of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (G.E.); Dept. of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland (H.J.); Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (H.J.); Dept. of Pediatric Oncology/Hematology/Immunology, Olgahospital, Klinikum Stuttgart, Stuttgart, Germany (K.E.); Murdoch Children’s Research Inst., The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, Australia (L.LE); Children’s Cancer Centre, The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, 3052, Australia (L.LE); Dept. of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia (L.LE); Crown Princess Victoria Children's Hospital, Linköping University Hospital, Linköping, Sweden (N.P.); Dept. of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden (N.P.); Dept. of Pediatric Oncology and Hematology, Skåne University Hospital, Lund University, Lund, Sweden (Ø.I); Dept. of Pediatrics, Pediatric Hematology and Oncology Ward, Kuopio University Hospital and Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (P.J.); Dept. of Clinical Pathology, Kuopio University Hospital and Unit of Pathology, Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (R.T.); Dept. of Neuro-Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands (R.RE.); Dept. of Hematology-Oncology, Valley Children's Hospital, Madera, CA, USA (S.D.); Rare Cancers Genomics Team, Genomic Epidemiology Branch, International Agency for Research on Cancer/World Health Organization, Lyon, France (S-O.A.); Inst. of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Dept. of Pathology and Molecular Medicine, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic (Z.J.); Division of Pediatric Glioma Research, Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany (J.D.T.W., K.M.K.); Division of Pediatric Glioma Research (B360), German Cancer Research Center (DKFZ), Heidelberg, Germany (J.D.T.W., K.M.K.); National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Germany (J.D.T.W., K.M.K.); Dept. of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Inst. of Health, Berlin, Germany (V.H.K.); Dept. of Paediatric and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark (V.H.K.); (European Society for Paediatric Oncology (SIOPE)-Brain Tumour Group.
DTW Jones
From the Inst. of Neuroradiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany (T.A.); Dept. of Neuroradiology, University Hospital Augsburg, Germany (B.B.); Neuroradiological Reference Center for the pediatric brain tumor (HIT) studies of the German Society of Pediatric Oncology and Hematology, Faculty of Medicine, University Augsburg, Augsburg, Germany (B.B.); Service de Neurochirurgie B, CHU de Bordeaux, University of Bourdeaux, France (E.J.); Univ. Bordeaux, Bordeaux INP, CNRS, IMB, UMR 5251, Talence, France (E.J.); Institut de Pathologie Multisite-Site Est, Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France (F.T., M.D., V.A.); Aix- Marseille Univ, APHM, CNRS, INP, Inst Neurophysiopathol, CHU Timone, Service d'Anatomie Pathologique et de Neuropathologie, Marseille, France (FB.D.); Dept. of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (G.E.); Dept. of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland (H.J.); Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (H.J.); Dept. of Pediatric Oncology/Hematology/Immunology, Olgahospital, Klinikum Stuttgart, Stuttgart, Germany (K.E.); Murdoch Children’s Research Inst., The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, Australia (L.LE); Children’s Cancer Centre, The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, 3052, Australia (L.LE); Dept. of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia (L.LE); Crown Princess Victoria Children's Hospital, Linköping University Hospital, Linköping, Sweden (N.P.); Dept. of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden (N.P.); Dept. of Pediatric Oncology and Hematology, Skåne University Hospital, Lund University, Lund, Sweden (Ø.I); Dept. of Pediatrics, Pediatric Hematology and Oncology Ward, Kuopio University Hospital and Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (P.J.); Dept. of Clinical Pathology, Kuopio University Hospital and Unit of Pathology, Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (R.T.); Dept. of Neuro-Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands (R.RE.); Dept. of Hematology-Oncology, Valley Children's Hospital, Madera, CA, USA (S.D.); Rare Cancers Genomics Team, Genomic Epidemiology Branch, International Agency for Research on Cancer/World Health Organization, Lyon, France (S-O.A.); Inst. of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Dept. of Pathology and Molecular Medicine, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic (Z.J.); Division of Pediatric Glioma Research, Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany (J.D.T.W., K.M.K.); Division of Pediatric Glioma Research (B360), German Cancer Research Center (DKFZ), Heidelberg, Germany (J.D.T.W., K.M.K.); National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Germany (J.D.T.W., K.M.K.); Dept. of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Inst. of Health, Berlin, Germany (V.H.K.); Dept. of Paediatric and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark (V.H.K.); (European Society for Paediatric Oncology (SIOPE)-Brain Tumour Group.
MK Keck
From the Inst. of Neuroradiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany (T.A.); Dept. of Neuroradiology, University Hospital Augsburg, Germany (B.B.); Neuroradiological Reference Center for the pediatric brain tumor (HIT) studies of the German Society of Pediatric Oncology and Hematology, Faculty of Medicine, University Augsburg, Augsburg, Germany (B.B.); Service de Neurochirurgie B, CHU de Bordeaux, University of Bourdeaux, France (E.J.); Univ. Bordeaux, Bordeaux INP, CNRS, IMB, UMR 5251, Talence, France (E.J.); Institut de Pathologie Multisite-Site Est, Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France (F.T., M.D., V.A.); Aix- Marseille Univ, APHM, CNRS, INP, Inst Neurophysiopathol, CHU Timone, Service d'Anatomie Pathologique et de Neuropathologie, Marseille, France (FB.D.); Dept. of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (G.E.); Dept. of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland (H.J.); Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (H.J.); Dept. of Pediatric Oncology/Hematology/Immunology, Olgahospital, Klinikum Stuttgart, Stuttgart, Germany (K.E.); Murdoch Children’s Research Inst., The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, Australia (L.LE); Children’s Cancer Centre, The Royal Children’s Hospital, Flemington Road, Parkville, Victoria, 3052, Australia (L.LE); Dept. of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia (L.LE); Crown Princess Victoria Children's Hospital, Linköping University Hospital, Linköping, Sweden (N.P.); Dept. of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden (N.P.); Dept. of Pediatric Oncology and Hematology, Skåne University Hospital, Lund University, Lund, Sweden (Ø.I); Dept. of Pediatrics, Pediatric Hematology and Oncology Ward, Kuopio University Hospital and Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (P.J.); Dept. of Clinical Pathology, Kuopio University Hospital and Unit of Pathology, Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (R.T.); Dept. of Neuro-Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands (R.RE.); Dept. of Hematology-Oncology, Valley Children's Hospital, Madera, CA, USA (S.D.); Rare Cancers Genomics Team, Genomic Epidemiology Branch, International Agency for Research on Cancer/World Health Organization, Lyon, France (S-O.A.); Inst. of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Dept. of Pathology and Molecular Medicine, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic (Z.J.); Division of Pediatric Glioma Research, Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany (J.D.T.W., K.M.K.); Division of Pediatric Glioma Research (B360), German Cancer Research Center (DKFZ), Heidelberg, Germany (J.D.T.W., K.M.K.); National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Germany (J.D.T.W., K.M.K.); Dept. of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Inst. of Health, Berlin, Germany (V.H.K.); Dept. of Paediatric and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark (V.H.K.); (European Society for Paediatric Oncology (SIOPE)-Brain Tumour Group.
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Accepted Manuscript
A Tietze, B Bison, European Society for Paediatric Oncology (SIOPE)-Brain Tumour Group, J Engelhardt, T Fenouil, D Figarella-Branger, E Goebell, J Hakumäki, E Koscielniak, LE Ludlow, D Meyronet, P Nyman, I Øra, J Pesola, T Rauramaa, RE Reddingius, D Samuel, A Sexton-Oates, A Vasiljevic, AK Wefers, J Zamecnik, DTW Jones, MK Keck, K von Hoff
CNS Embryonal Tumor with PLAGL Amplification, a New Tumor Type in Children and Adolescents: Insights from a Comprehensive MRI Analysis
American Journal of Neuroradiology Sep 2024, ajnr.A8496; DOI: 10.3174/ajnr.A8496
Accepted Manuscript
CNS Embryonal Tumor with PLAGL Amplification, a New Tumor Type in Children and Adolescents: Insights from a Comprehensive MRI Analysis
A Tietze, B Bison, European Society for Paediatric Oncology (SIOPE)-Brain Tumour Group, J Engelhardt, T Fenouil, D Figarella-Branger, E Goebell, J Hakumäki, E Koscielniak, LE Ludlow, D Meyronet, P Nyman, I Øra, J Pesola, T Rauramaa, RE Reddingius, D Samuel, A Sexton-Oates, A Vasiljevic, AK Wefers, J Zamecnik, DTW Jones, MK Keck, K von Hoff
American Journal of Neuroradiology Sep 2024, ajnr.A8496; DOI: 10.3174/ajnr.A8496
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