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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticlePEDIATRIC NEUROIMAGING

Development of Myelin Growth Charts of the White Matter Using T1 Relaxometry

Chang Y. Ho, Scott Persohn, Meghana Sankar and Paul R. Territo
American Journal of Neuroradiology July 2024, DOI: https://doi.org/10.3174/ajnr.A8306
Chang Y. Ho
aFrom the Department of Radiology and Imaging Sciences (C.Y.H., P.R.T.), Indiana University School of Medicine, Indianapolis, Indiana
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Scott Persohn
bDepartment of Medicine (S.P., M.S., P.R.T.), Indiana University School of Medicine, Indianapolis, Indiana
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Meghana Sankar
bDepartment of Medicine (S.P., M.S., P.R.T.), Indiana University School of Medicine, Indianapolis, Indiana
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Paul R. Territo
aFrom the Department of Radiology and Imaging Sciences (C.Y.H., P.R.T.), Indiana University School of Medicine, Indianapolis, Indiana
bDepartment of Medicine (S.P., M.S., P.R.T.), Indiana University School of Medicine, Indianapolis, Indiana
cStark Neuroscience Research Institute (P.R.T.), Indiana University School of Medicine, Indianapolis, Indiana
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Figures

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  • FIG 1.
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    FIG 1.

    Scatterplot with trendline and percentile lines of the pons crossing tract. This includes the entire cohort (A) as well as a magnified view for the cohort in the first year of life (B).

  • FIG 2.
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    FIG 2.

    Scatterplot with trendline and percentile lines of the middle cerebellar peduncle. This includes the entire cohort (A) as well as a magnified view for the cohort in the first year of life (B).

  • FIG 3.
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    FIG 3.

    Scatterplot with trendline and percentile lines of the posterior limb of the internal capsule. This includes the entire cohort (A) as well as a magnified view for the cohort in the first year of life (B).

  • FIG 4.
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    FIG 4.

    Scatterplot with trendline and percentile lines of the anterior limb of the internal capsule. This includes the entire cohort (A) as well as a magnified view for the cohort in the first year of life (B).

  • FIG 5.
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    FIG 5.

    Scatterplot with trendline and percentile lines of the splenium of the corpus callosum. This includes the entire cohort (A) as well as a magnified view for the cohort in the first year of life (B).

  • FIG 6.
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    FIG 6.

    Scatterplot with trendline and percentile lines of the genu of the corpus callosum. This includes the entire cohort (A) as well as a magnified view for the cohort in the first year of life (B).

  • FIG 7.
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    FIG 7.

    Scatterplot with the trendline of select white matter atlas regions. This includes the entire cohort (A), and the magnified view of the cohort in the first year of life (B). ACR indicates anterior corona radiata; ALIC, anterior limb of internal capsule; BCC, body of corpus callosum; CP, cerebral peduncle; CST, corticospinal tract; EC, external capsule; GCC, genu of corpus callosum; ICP, inferior cerebellar peduncle; MCP, middle cerebellar peduncle; ML, medial lemniscus; PCR, posterior corona radiata; PCT, pontine crossing tract; PLIC, posterior limb of the internal capsule; PTR, posterior thalamic radiation; RLIC, retrolenticular internal capsule; SCC, splenium corpus callosum; SCP, superior cerebellar peduncle; SCR, superior corona radiata; UNC, uncinate fasiculus.

  • FIG 8.
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    FIG 8.

    A, Pearson Product Moment Interobserver Comparison for white matter. B, Pearson Product Moment Interobserver Comparison for gyral anatomy.

Tables

  • Figures
  • Indications for MR imaging

    Indications
    Seizures or spasms26
    Headaches22
    Developmental delay16
    Cutaneous or subcutaneous head and neck lesions10
    Abnormal eye movement7
    Attention deficit/hyperactivity disorder4
    Chiari I4
    Non-CNS malformations3
    Macrocephaly2
    Narcolepsy2
    Autism1
    Failure to thrive1
    Hearing loss1
    Hypertonia1
    Hypoxic-ischemic encephalopathy1
    Nonaccidental trauma work-up1
    Vomiting1
    Total103
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Cite this article
Chang Y. Ho, Scott Persohn, Meghana Sankar, Paul R. Territo
Development of Myelin Growth Charts of the White Matter Using T1 Relaxometry
American Journal of Neuroradiology Jul 2024, DOI: 10.3174/ajnr.A8306

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Development of Myelin Growth Charts of the White Matter Using T1 Relaxometry
Chang Y. Ho, Scott Persohn, Meghana Sankar, Paul R. Territo
American Journal of Neuroradiology Jul 2024, DOI: 10.3174/ajnr.A8306
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