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Research ArticleNeurointervention

Use of the Neuroform Atlas Stent or LVIS Jr Stent for Treatment of Unruptured Intracranial Aneurysms in Parent Arteries of <2 mm in Diameter: A Multicenter Experience

Tengfei Li, Shuailong Shi, Qingliang Chen, Chao Jiang, Wenxian Feng, Qi Tian, Shuhai Long, Zhuangzhuang Wei, Jie Yang, Ye Wang, Jianzhuang Ren, Xinwei Han and Ji Ma
American Journal of Neuroradiology June 2024, DOI: https://doi.org/10.3174/ajnr.A8238
Tengfei Li
aFrom the Department of Interventional Radiology (T.L., S.S., Q.T., S.L., Z.W., JY., Y.W., J.R., X.H., J.M.), The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
bInterventional Institute of Zhengzhou University (T.L., S.S., Q.T., S.L., Z.W., JY., Y.W., J.R., X.H., J.M.), Zhengzhou, China
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Shuailong Shi
aFrom the Department of Interventional Radiology (T.L., S.S., Q.T., S.L., Z.W., JY., Y.W., J.R., X.H., J.M.), The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
bInterventional Institute of Zhengzhou University (T.L., S.S., Q.T., S.L., Z.W., JY., Y.W., J.R., X.H., J.M.), Zhengzhou, China
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Qingliang Chen
cDepartment of Interventional Radiology (Q.C.), The Third People’s Hospital of Henan Province, Zhengzhou, China
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Chao Jiang
dDepartment of Neurology (C.J.), The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, China
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Wenxian Feng
eDepartment of Interventional Radiology (W.F.), Zhumadian Central Hospital, Zhumadian, China.
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Qi Tian
aFrom the Department of Interventional Radiology (T.L., S.S., Q.T., S.L., Z.W., JY., Y.W., J.R., X.H., J.M.), The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
bInterventional Institute of Zhengzhou University (T.L., S.S., Q.T., S.L., Z.W., JY., Y.W., J.R., X.H., J.M.), Zhengzhou, China
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Shuhai Long
aFrom the Department of Interventional Radiology (T.L., S.S., Q.T., S.L., Z.W., JY., Y.W., J.R., X.H., J.M.), The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
bInterventional Institute of Zhengzhou University (T.L., S.S., Q.T., S.L., Z.W., JY., Y.W., J.R., X.H., J.M.), Zhengzhou, China
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Zhuangzhuang Wei
aFrom the Department of Interventional Radiology (T.L., S.S., Q.T., S.L., Z.W., JY., Y.W., J.R., X.H., J.M.), The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
bInterventional Institute of Zhengzhou University (T.L., S.S., Q.T., S.L., Z.W., JY., Y.W., J.R., X.H., J.M.), Zhengzhou, China
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Jie Yang
aFrom the Department of Interventional Radiology (T.L., S.S., Q.T., S.L., Z.W., JY., Y.W., J.R., X.H., J.M.), The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
bInterventional Institute of Zhengzhou University (T.L., S.S., Q.T., S.L., Z.W., JY., Y.W., J.R., X.H., J.M.), Zhengzhou, China
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Ye Wang
aFrom the Department of Interventional Radiology (T.L., S.S., Q.T., S.L., Z.W., JY., Y.W., J.R., X.H., J.M.), The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
bInterventional Institute of Zhengzhou University (T.L., S.S., Q.T., S.L., Z.W., JY., Y.W., J.R., X.H., J.M.), Zhengzhou, China
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Jianzhuang Ren
aFrom the Department of Interventional Radiology (T.L., S.S., Q.T., S.L., Z.W., JY., Y.W., J.R., X.H., J.M.), The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
bInterventional Institute of Zhengzhou University (T.L., S.S., Q.T., S.L., Z.W., JY., Y.W., J.R., X.H., J.M.), Zhengzhou, China
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Xinwei Han
aFrom the Department of Interventional Radiology (T.L., S.S., Q.T., S.L., Z.W., JY., Y.W., J.R., X.H., J.M.), The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
bInterventional Institute of Zhengzhou University (T.L., S.S., Q.T., S.L., Z.W., JY., Y.W., J.R., X.H., J.M.), Zhengzhou, China
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Ji Ma
aFrom the Department of Interventional Radiology (T.L., S.S., Q.T., S.L., Z.W., JY., Y.W., J.R., X.H., J.M.), The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
bInterventional Institute of Zhengzhou University (T.L., S.S., Q.T., S.L., Z.W., JY., Y.W., J.R., X.H., J.M.), Zhengzhou, China
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    FIG 1.

    Flow chart of patient selection.

  • FIG 2.
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    FIG 2.

    Use of the Neuroform Atlas stent in SAC for the treatment of an unruptured anterior communicating artery aneurysm. A, 2D DSA of the right ICA shows the right A1 artery to be slender and the anterior communicating artery to be open. B, 2D DSA of the left ICA shows an aneurysm of the anterior communicating artery of 2.2 × 4.5 mm. The anterior communicating artery sends out a median callosal artery and the bilateral A2 arteries together to form a triploid anterior cerebral artery (aneurysm is shown by a white arrow). C and D, 3D DSA shows the position between the 3 A2 arteries and the aneurysms (blue dashed line denotes the stent-placement area, the parent artery diameter is 1.91 mm, and the diameter mismatch ratio is 1.09). E, SAC using a Neuroform Atlas stent (3.0 × 24 mm) was performed, and the occlusion attenuation of the aneurysm was Raymond-Roy class I (white arrows indicate the ends of the stent). F and G, HR-CBCT with diluted contrast media shows complete stent apposition and satisfactory protection of the coils at the aneurysm neck (the stent wire at the aneurysm neck is indicated by white arrows). H, DSA follow-up at 6 months shows the stent patency and well-healed aneurysm (Raymond-Roy class I).

  • FIG 3.
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    FIG 3.

    Use of the LVIS Jr stent in SAC for the treatment of an unruptured A2-segment aneurysm. A and B, 2D DSA and 3D DSA of the right ICA show an A2-segment aneurysm of the right anterior cerebral artery, with an irregular shape and a size of 1.5 × 2.7 mm. The parent artery diameter is 1.79 mm, and the diameter mismatch ratio is 1.15 (aneurysm is shown by a white arrow). C, SAC using a LVIS Jr stent (2.5 × 13 mm) was performed, and the aneurysm occlusion attenuation was Raymond-Roy class I (white arrows indicate the ends of the stent). D, HR-CBCT with diluted contrast media shows that the stent was completely deployed and stent angles were 43.34° (the stent angles are indicated by a white arrow). E, HR-CBCT shows complete stent apposition at the aneurysm neck and the coils protected satisfactorily (stent wire at the aneurysm neck is indicated by white arrows). F. DSA follow-up at 6 months shows stent patency, and the aneurysm has healed well (Raymond–Roy class I).

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    Table 1:

    Included variables and assignment in multivariable regression analysis of incomplete stent appositiona

    VariableNameAssign
    Aneurysm domeX1Quantitative variable
    Aneurysm neckX2Quantitative variable
    Parent artery diameter mismatch ratioX3<1.25 = 0a, ≥1.25 = 1
    Paren artery stenosisX4No = 0a, yes = 1
    Stent typeX5Atlas = 0a, LVIS Jr = 1
    Stent anglesX6<75°= 0a, ≥75°= 1
    • ↵a A value of zero was assigned as the reference group.

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    Table 2:

    Multivariable logistic analysis of the factors associated with incomplete stent apposition of unruptured intracranial aneurysms treated with Neuroform Atlas or LVIS Jr stents

    VariableOR95% CIP Value
    Aneurysm dome1.1220.655∼1.922.675
    Aneurysm neck1.6830.936∼3.027.082
    Parent artery diameter mismatch ratio8.0431.137∼56.895.037
    Parent artery stenosis1.7940.310∼10.369.514
    Stent type20.2971.794∼229.636.015
    Stent angles23.9632.602∼220.693.005
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Tengfei Li, Shuailong Shi, Qingliang Chen, Chao Jiang, Wenxian Feng, Qi Tian, Shuhai Long, Zhuangzhuang Wei, Jie Yang, Ye Wang, Jianzhuang Ren, Xinwei Han, Ji Ma
Use of the Neuroform Atlas Stent or LVIS Jr Stent for Treatment of Unruptured Intracranial Aneurysms in Parent Arteries of <2 mm in Diameter: A Multicenter Experience
American Journal of Neuroradiology Jun 2024, DOI: 10.3174/ajnr.A8238

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Use of the Neuroform Atlas Stent or LVIS Jr Stent for Treatment of Unruptured Intracranial Aneurysms in Parent Arteries of <2 mm in Diameter: A Multicenter Experience
Tengfei Li, Shuailong Shi, Qingliang Chen, Chao Jiang, Wenxian Feng, Qi Tian, Shuhai Long, Zhuangzhuang Wei, Jie Yang, Ye Wang, Jianzhuang Ren, Xinwei Han, Ji Ma
American Journal of Neuroradiology Jun 2024, DOI: 10.3174/ajnr.A8238
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